Following connexon oligomerization, the hemichannels must be transported to the plasma membrane. This has been shown to occur in transport vesicles called "cargo containers". Most of post-Golgi cargo containers have a diameter of of 50- 200 nm (Lauf et al., 2002). Recently direct transport of connexins to GJ assembly sides has been described (Shaw et al., 2007). Besides microtuble-dependent trafficking, a microtubule-independent delivery pathway may exist as concluded from studies using the secretory transport inhibitor, Brefeldin A (Musil and Goodenough 1993; De Sousa et al. 1993; Laird et al. 1995).
Goodenough, DA, Musil, LS
Jan, LY, Shaw, RM, Jan, YN, Fay, AJ, Puthenveedu, MA, von Zastrow, M
Braconnot, S, Lauf, U, Chen, SC, Giepmans, BN, Lopez, P, Falk, MM
Valdimarsson, G, De Sousa, PA, Nicholson, BJ, Kidder, GM
Kasprzak, L, Laird, DW, Castillo, M
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