Reactome | NCAM1 [plasma membrane]

NCAM1 [plasma membrane]

Stable Identifier

R-HSA-190987

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Neural cell adhesion molecule 1, 140 kDa isoform, NCA1_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
        
        NCAM:pFyn-Y420 [plasma membrane] (Homo sapiens)
        
        NCAM1:NCAM1 trans-homotetramer [plasma membrane] (Homo sapiens)
        
        NCAM1 cis-homodimer [plasma membrane] (Homo sapiens)
        
        NCAM1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P13591 NCAM1

Gene Names

NCAM1, NCAM

Chain

signal peptide:1-19, chain:20-858

Reference Genes

BioGPS Gene:4684 NCAM1

COSMIC (genes):NCAM1 NCAM1

CTD Gene:4684 NCAM1

dbSNP Gene:4684 NCAM1

ENSEMBL:ENSG00000149294 NCAM1

ENSEMBL_homo_sapiens_GENE:ENSG00000149294.18 NCAM1

HGNC:7656 NCAM1

KEGG Gene (Homo sapiens):4684 NCAM1

Monarch:4684 NCAM1

NCBI Gene:4684 NCAM1

OMIM:116930 NCAM1

UCSC:P13591 NCAM1

Reference Transcript

Other Identifiers

1111_at

1112_g_at

11727914_s_at

11727915_a_at

11730720_a_at

11730721_a_at

11730722_a_at

11730723_a_at

1566_at

16731297

209968_PM_s_at

209968_s_at

212843_PM_at

212843_at

214952_PM_at

214952_at

217359_PM_s_at

217359_s_at

227394_PM_at

227394_at

229799_PM_s_at

229799_s_at

3349294

3349295

3349341

3349343

3349344

3349345

3349348

3349349

3349352

3349355

3349356

3349363

3349364

3349365

3349366

3349368

3349371

3349372

3349381

3349382

3349383

3349384

3349385

3349386

3349387

3349388

3349389

3349392

3349393

3349400

3349401

3349402

3349403

3349404

38243_at

41289_at

4684

47883_at

7943892

A_14_P132913

A_14_P139368

A_23_P1740

A_23_P203053

A_33_P3363799

A_33_P3363804

GE616436

GE85957

GO:0000139

GO:0001618

GO:0001837

GO:0005515

GO:0005576

GO:0005794

GO:0005829

GO:0005886

GO:0007155

GO:0007411

GO:0009897

GO:0009986

GO:0016020

GO:0023052

GO:0030154

GO:0030312

GO:0031012

GO:0043226

GO:0046718

GO:0048856

GO:0062023

GO:0071679

GO:0098552

GO:2001260

HMNXSV003038469

HMNXSV003048896

Hs.167988.1.S1_3p_at

Hs.167988.3.S1_3p_a_at

Hs.167988.4.S1_3p_at

Hs.288936.1.A1_3p_at

Hs.78792.0.A1_3p_s_at

ILMN_1676289

ILMN_1702305

PH_hs_0022189

S71824_at

g1439612_3p_a_at

Participates

as a member of

as a component of

as an input of

Other forms of this molecule

6xN-linked glycan core-NCAM1 [Golgi membrane]

Inferred To

NCAM1 [plasma membrane] (Canis familiaris)

NCAM1 [plasma membrane] (Mus musculus)

Ncam1 [plasma membrane] (Rattus norvegicus)

Ghost homologue of NCAM1 [plasma membrane] (Bos taurus)

Ghost homologue of NCAM1 [plasma membrane] (Caenorhabditis elegans)

Ghost homologue of NCAM1 [plasma membrane] (Drosophila melanogaster)

Ghost homologue of NCAM1 [plasma membrane] (Gallus gallus)

Ghost homologue of NCAM1 [plasma membrane] (Sus scrofa)

Ghost homologue of NCAM1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000606.3, NP_001229537.1, NP_851996.2, NP_001070150.1

Guide to Pharmacology - Targets

2769

OpenTargets

ENSG00000149294

HPA

ENSG00000149294-NCAM1

GeneCards

P13591

Ensembl

ENST00000621850, ENST00000531044, ENSP00000482205, ENSP00000318472, ENST00000529356, ENST00000316851, ENSP00000484943, ENSP00000480774, ENSP00000481083, ENST00000621128, ENSG00000149294

PRO

P13591

Pharos - Targets

P13591

PDB

5LKN, 2E3V, 3MTR, 2VKX, 2HAZ, 5AEA, 2VKW

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:P25098 GRK2	4	p-S29-ADRBK1 [cytosol] (R-HSA-9645318) ADRBK1 [cilium] (R-HSA-5632504) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969) GRK2 [plasma membrane] (R-HSA-50270)	0.556	3

Cite Us!