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SEL1L [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-1911545
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, TSA305, UNQ128/PRO1063
Locations in the PathwayBrowser for interactor UniProt:P04578 env
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Processing in Golgi (Homo sapiens)
Transport of NOTCH precursor to Golgi (Homo sapiens)
SEL1L [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBV2 SEL1L
Gene Names
SEL1L, TSA305, UNQ128/PRO1063
Chain
signal peptide:1-21, chain:22-794
Reference Genes
BioGPS Gene:6400 SEL1L
COSMIC (genes):SEL1L SEL1L
CTD Gene:6400 SEL1L
dbSNP Gene:6400 SEL1L
ENSEMBL:ENSG00000071537 SEL1L
HGNC:10717 SEL1L
KEGG Gene (Homo sapiens):6400 SEL1L
Monarch:6400 SEL1L
NCBI Gene:6400 SEL1L
OMIM:602329 SEL1L
UCSC:Q9UBV2 SEL1L
Reference Transcript
RefSeq:NM_001244984.1 SEL1L
RefSeq:NM_005065.5 SEL1L
Other Identifiers
0001780551
11717203_at
11717204_at
11758767_a_at
11762663_at
16795394
202061_PM_s_at
202061_s_at
202062_PM_s_at
202062_s_at
202063_PM_s_at
202063_s_at
202064_PM_s_at
202064_s_at
3574212
3574213
3574214
3574215
3574216
3574217
3574218
3574219
3574220
3574222
3574223
3574224
3574225
3574227
3574228
3574229
3574232
3574234
3574236
3574238
3574239
3574242
3574243
3574244
3574245
3574246
3574247
3574248
3574249
3574251
3574252
3574254
3574255
3574257
3574258
3574262
3574263
40689_at
6400
65740_at
76761_at
7980547
A_23_P88411
A_24_P219114
A_33_P3275968
A_33_P3404701
GE61258
GO:0000836
GO:0000839
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0006629
GO:0006641
GO:0006810
GO:0006950
GO:0007165
GO:0007219
GO:0008150
GO:0009056
GO:0009306
GO:0015031
GO:0016020
GO:0016021
GO:0030433
GO:0030970
GO:0032991
GO:0034976
GO:0036503
GO:0036513
GO:0043226
GO:0050821
HMNXSV003012387
HMNXSV003054768
Hs.181300.0.S3_3p_a_at
ILMN_1726496
PH_hs_0010727
TC14001372.hg
U11037_at
g4826995_3p_a_at
g6518494_3p_s_at
g6851088_3p_a_at
Participates
as a component of
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
OS9:SEL1:ERAD E3 ligases:DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
This entity regulates
Negatively
Transport of NOTCH precursor to Golgi
(Homo sapiens)
Inferred To
sel1l [endoplasmic reticulum membrane]
(Danio rerio)
sel1l [endoplasmic reticulum membrane]
(Xenopus tropicalis)
SEL1L [endoplasmic reticulum membrane]
(Bos taurus)
SEL1L [endoplasmic reticulum membrane]
(Canis familiaris)
SEL1L [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
SEL1L [endoplasmic reticulum membrane]
(Gallus gallus)
SEL1L [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
SEL1L [endoplasmic reticulum membrane]
(Sus scrofa)
sel-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Hrd3 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Sel1l [endoplasmic reticulum membrane]
(Mus musculus)
Sel1l [endoplasmic reticulum membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_005056.3
,
NP_001231913.1
OpenTargets
ENSG00000071537
HPA
ENSG00000071537-SEL1L
GeneCards
Q9UBV2
Ensembl
ENST00000336735
,
ENST00000555824
,
ENSP00000337053
,
ENSP00000450709
,
ENSG00000071537
PRO
Q9UBV2
Pharos - Targets
Q9UBV2
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.823
11
UniProt:Q8IWF2 FXRD2
0.723
6
UniProt:Q86TM6 SYVN1
1
SYVN1(1-617) [endoplasmic reticulum membrane]
(R-HSA-535496)
0.708
20
UniProt:Q9Y385 UBE2J1
1
UBE2J1 [cytosol]
(R-HSA-947625)
0.643
6
UniProt:Q9UBU6 FA8A1
0.597
5
UniProt:Q96CS3 FAF2
3
FAF2 [cytosol]
(R-HSA-6781921)
FAF2 [extracellular region]
(R-HSA-6806183)
FAF2 [azurophil granule lumen]
(R-HSA-6799138)
0.527
2
UniProt:Q9Y679 AUP1
0.527
5
UniProt:Q96DZ1 ERLEC1
1
ERLEC1 [endoplasmic reticulum quality control compartment]
(R-HSA-5362354)
0.527
6
UniProt:O75460-1 ERN1
0.499
2
UniProt:P04578-PRO_0000038428 ENV
0.462
4
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
ENV [viral envelope]
(R-HIV-173439)
0.462
4
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