Reactome | SEL1L [endoplasmic reticulum membrane]

SEL1L [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-1911545

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, TSA305, UNQ128/PRO1063

Locations in the PathwayBrowser for interactor UniProt:Q96DZ1 ERLEC1

Expand all

External Reference Information

External Reference

UniProt:Q9UBV2 SEL1L

Gene Names

SEL1L, TSA305, UNQ128/PRO1063

Chain

signal peptide:1-21, chain:22-794

Reference Genes

BioGPS Gene:6400 SEL1L

COSMIC (genes):SEL1L SEL1L

CTD Gene:6400 SEL1L

dbSNP Gene:6400 SEL1L

ENSEMBL:ENSG00000071537 SEL1L

HGNC:10717 SEL1L

KEGG:hsa:6400 SEL1L

Monarch:6400 SEL1L

NCBI Gene:6400 SEL1L

OMIM:602329 SEL1L

UCSC:Q9UBV2 SEL1L

Reference Transcript

Other Identifiers

11717203_at

11717204_at

11758767_a_at

11762663_at

16795394

202061_PM_s_at

202061_s_at

202062_PM_s_at

202062_s_at

202063_PM_s_at

202063_s_at

202064_PM_s_at

202064_s_at

3574212

3574213

3574214

3574215

3574216

3574217

3574218

3574219

3574220

3574221

3574222

3574223

3574224

3574225

3574226

3574227

3574228

3574229

3574232

3574233

3574234

3574235

3574236

3574238

3574239

3574242

3574243

3574244

3574245

3574246

3574247

3574248

3574249

3574251

3574252

3574254

3574255

3574257

3574258

3574262

3574263

40689_at

6400

65740_at

76761_at

7980547

A_23_P88411

A_24_P219114

A_33_P3275968

A_33_P3404701

GE61258

GO:0000836

GO:0000839

GO:0005515

GO:0005783

GO:0005789

GO:0006629

GO:0006641

GO:0006886

GO:0007219

GO:0009306

GO:0016020

GO:0030163

GO:0030970

GO:0034976

GO:0036503

GO:0036513

GO:0043226

GO:0050821

HMNXSV003012387

HMNXSV003054768

Hs.181300.0.S3_3p_a_at

ILMN_1726496

PH_hs_0010727

TC14001372.hg

U11037_at

g4826995_3p_a_at

g6518494_3p_s_at

g6851088_3p_a_at

Participates

as a component of

This entity regulates

Negatively

Transport of NOTCH precursor to Golgi (Homo sapiens)

Inferred To

SEL1L [endoplasmic reticulum membrane] (Bos taurus)

SEL1L [endoplasmic reticulum membrane] (Canis familiaris)

SEL1L [endoplasmic reticulum membrane] (Dictyostelium discoideum)

SEL1L [endoplasmic reticulum membrane] (Gallus gallus)

SEL1L [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

SEL1L [endoplasmic reticulum membrane] (Sus scrofa)

sel-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Hrd3 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Ghost homologue of SEL1L [endoplasmic reticulum membrane] (Danio rerio)

Ghost homologue of SEL1L [endoplasmic reticulum membrane] (Xenopus tropicalis)

Sel1l [endoplasmic reticulum membrane] (Mus musculus)

Sel1l [endoplasmic reticulum membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_005056.3, NP_001231913.1

ENSEMBL

ENST00000336735, ENSP00000337053, ENST00000555824, ENSP00000450709

OpenTargets

ENSG00000071537

HPA

ENSG00000071537-SEL1L

PRO

Q9UBV2

Pharos - Targets

Q9UBV2

GlyGen

Q9UBV2

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.864	14
UniProt:Q8IWF2 FXRD2			0.784	7
UniProt:Q86TM6 SYVN1	1	SYVN1(1-617) [endoplasmic reticulum membrane] (R-HSA-535496)	0.773	21
UniProt:Q9Y385 UBE2J1	1	UBE2J1 [cytosol] (R-HSA-947625)	0.643	6
UniProt:Q9UBU6 FA8A1			0.597	5
UniProt:Q86WK7 AMGO3			0.527	2
UniProt:Q9Y2B1 RXLT1			0.527	2
UniProt:Q96CS3 FAF2	3	FAF2 [cytosol] (R-HSA-6781921) FAF2 [extracellular region] (R-HSA-6806183) FAF2 [azurophil granule lumen] (R-HSA-6799138)	0.527	2
UniProt:Q9Y679 AUP1			0.527	5
UniProt:P20231 TRYB2			0.527	2
UniProt:Q9NRB3 CHST12	1	CHST12 [Golgi membrane] (R-HSA-1971456)	0.527	2
UniProt:Q8WXQ8 CBPA5			0.527	2
UniProt:Q96DZ1 ERLEC1	1	ERLEC1 [endoplasmic reticulum quality control compartment] (R-HSA-5362354)	0.527	6
UniProt:Q9UQ74 PSG8	1	PSG8 [extracellular region] (R-HSA-8870757)	0.527	2
UniProt:O75460-1 ERN1			0.499	2
UniProt:Q16288 NTRK3	6	p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718) NTRK3 [plasma membrane] (R-HSA-6798240) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(32-495) [plasma membrane] (R-HSA-9603541)	0.499	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.499	2
UniProt:P04578-PRO_0000038428 ENV			0.462	4
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	4

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