Reactome | Mature NOTCH heterodimer traffics to the plasma membrane

Mature NOTCH heterodimer traffics to the plasma membrane

Stable Identifier

R-HSA-1912382

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Mature NOTCH heterodimer traffics to the plasma membrane

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Mature NOTCH translocates from the Golgi to plasma membrane. In Caenorhabditis elegans, a Golgi membrane protein sel-9, a homolog of mammalian TMED2, acts as a quality controller and prevents misfolded lin-12, a NOTCH homolog, to reach the cell surface.

Literature References

PubMed ID	Title	Journal	Year
10366590	p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans Wen, C, Greenwald, I	J Cell Biol	1999
11135303	Oh no, Notch again! Lendahl, U, Frisen, J	Bioessays	2001
9244302	Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane Artavanis-Tsakonas, S, Zagouras, P, Qi, H, Blaumueller, CM	Cell	1997