NICD1 is phosphorylated by CDK8

Stable Identifier
R-HSA-1912391
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NICD1 is phosphorylated by CDK8
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CDK8 phosphorylates conserved serine residues in the TAD and PEST domains of NICD1. Phosphorylation targets NICD1 for ubiquitination and degradation, ultimately terminating transcriptional activity of NOTCH1 (Fryer et al. 2004).
Literature References
PubMed ID Title Journal Year
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, White, JB, Jones, KA

Mol Cell 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of NOTCH1 Coactivator Complex:CDK8:CCNC [nucleoplasm]

Physical Entity
NOTCH1 Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
Activity
cyclin-dependent protein serine/threonine kinase activity (GO:0004693)
Inferred From
CDK8 phosphorylates xNICD1 (Homo sapiens)
Authored
Egan, SE  (2011-11-14)
Orlic-Milacic, M  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
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