Squalene is oxidized to its epoxide

Stable Identifier
R-HSA-191299
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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Squalene is oxidized to its epoxide
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Squalene monooxygenase (squalene epoxidase, SE) is located on the endoplamic reticulum. It catalyzes the oxidation of squalene to squalene 2,3-epoxide. SE seems to be an important rate-limiting enzyme in cholesterol biosynthesis.
Literature References
PubMed ID Title Journal Year
10666321 Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase

Tang, Y, Laden, BP, Porter, TD

Arch Biochem Biophys 2000
Participants
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Output
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as an event of
Catalyst Activity

squalene monooxygenase activity of SQLE:FAD [endoplasmic reticulum membrane]

Physical Entity
SQLE:FAD [endoplasmic reticulum membrane] (Homo sapiens)
Activity
squalene monooxygenase activity (GO:0004506)
Orthologous Events
Squalene is oxidized to its epoxide (Bos taurus)
Squalene is oxidized to its epoxide (Canis familiaris)
Squalene is oxidized to its epoxide (Danio rerio)
Squalene is oxidized to its epoxide (Dictyostelium discoideum)
Squalene is oxidized to its epoxide (Gallus gallus)
Squalene is oxidized to its epoxide (Mus musculus)
Squalene is oxidized to its epoxide (Rattus norvegicus)
Squalene is oxidized to its epoxide (Saccharomyces cerevisiae)
Squalene is oxidized to its epoxide (Schizosaccharomyces pombe)
Squalene is oxidized to its epoxide (Sus scrofa)
Squalene is oxidized to its epoxide (Xenopus tropicalis)
Authored
Jassal, B  (2007-01-24)
Reviewed
D'Eustachio, P  (2007-01-22)
Created
Jassal, B  (2007-01-19)
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