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HMGCS1 [cytosol]
Stable Identifier
R-HSA-191329
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Hydroxymethylglutaryl-CoA synthase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)
HMGCS1 [cytosol] (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
HMGCS1 [cytosol] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
HMGCS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01581 HMGCS1
Gene Names
HMGCS1, HMGCS
Chain
chain:1-520
Reference Genes
BioGPS Gene:3157 HMGCS1
COSMIC (genes):HMGCS1 HMGCS1
CTD Gene:3157 HMGCS1
dbSNP Gene:3157 HMGCS1
ENSEMBL:ENSG00000112972 HMGCS1
ENSEMBL_homo_sapiens_GENE:ENSG00000112972.15 HMGCS1
HGNC:5007 HMGCS1
KEGG Gene (Homo sapiens):3157 HMGCS1
Monarch:3157 HMGCS1
NCBI Gene:3157 HMGCS1
OMIM:142940 HMGCS1
UCSC:Q01581 HMGCS1
Reference Transcript
RefSeq:NM_001098272.2 HMGCS1
RefSeq:NM_001324223.1 HMGCS1
RefSeq:NM_001324222.1 HMGCS1
RefSeq:NM_001324220.1 HMGCS1
RefSeq:NM_002130.7 HMGCS1
RefSeq:NM_001330663.1 HMGCS1
RefSeq:NM_001324224.1 HMGCS1
RefSeq:NM_001324219.1 HMGCS1
Other Identifiers
11716987_a_at
11754918_s_at
16995890
205822_PM_s_at
205822_s_at
221750_PM_at
221750_at
2387715
2855498
2855500
2855502
2855503
2855504
2855505
2855506
2855507
2855508
2855509
2855512
2855513
2855514
2855516
2855518
2855520
2855522
2855523
2855524
2855526
2855527
2855528
2855529
2855531
2855535
3157
34517_at
54968_at
78228_s_at
8111941
A_23_P133263
A_24_P63522
GE59927
GE819180
GO:0003824
GO:0004421
GO:0005737
GO:0005829
GO:0006084
GO:0006629
GO:0006694
GO:0006695
GO:0006790
GO:0008202
GO:0008203
GO:0008299
GO:0010142
GO:0016126
GO:0016740
GO:0016746
GO:0042803
GO:0055086
GO:1901135
HMNXSV003048724
Hs.77910.1.S1_3p_at
ILMN_1797728
L25798_at
TC05001316.hg
TC05002982.hg
g4504428_3p_a_at
Participates
as an output of
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
Inferred To
ERG13 [cytosol]
(Saccharomyces cerevisiae)
HMGCS1 [cytosol]
(Bos taurus)
HMGCS1 [cytosol]
(Canis familiaris)
HMGCS1 [cytosol]
(Drosophila melanogaster)
HMGCS1 [cytosol]
(Gallus gallus)
HMGCS1 [cytosol]
(Mus musculus)
HMGCS1 [cytosol]
(Rattus norvegicus)
HMGCS1 [cytosol]
(Sus scrofa)
hgsB [cytosol]
(Dictyostelium discoideum)
hcs1 [cytosol]
(Schizosaccharomyces pombe)
hmgs-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001317592.1
,
NP_001311151.1
,
NP_001091742.1
,
NP_001311153.1
,
NP_001311152.1
,
NP_001311149.1
,
NP_002121.4
,
NP_001311148.1
Guide to Pharmacology - Targets
638
OpenTargets
ENSG00000112972
GeneCards
Q01581
HPA
ENSG00000112972-HMGCS1
Ensembl
ENSG00000112972
,
ENST00000433297
,
ENST00000325110
,
ENSP00000399402
,
ENSP00000322706
PRO
Q01581
Pharos - Targets
Q01581
HMDB Protein
HMDBP00053
PDB
2P8U
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