Squalene 2,3-epoxide cyclizes, forming lanosterol

Stable Identifier
R-HSA-191366
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
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Squalene 2,3-epoxide cyclizes, forming lanosterol
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Lanosterol synthase (LSS) catalyzes the cyclization of squalene 2,3-epoxide to lanosterol, a reaction that forms the sterol nucleus. LSS is located on the ER membrane and is active in monomeric form (Ruf et al. 2004).

Literature References
PubMed ID Title Journal Year
8593458 Molecular cloning of cDNA encoding human lanosterol synthase

Sankawa, U, Shibuya, M, Ebizuka, Y, Sung, CK

Biol Pharm Bull 1995
5918048 Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol

Van Tamelen, EE, Willett, JD, Clayton, RB, Lord, KE

J Am Chem Soc 1966
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Output
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as an event of
Catalyst Activity

lanosterol synthase activity of LSS [endoplasmic reticulum membrane]

Physical Entity
LSS [endoplasmic reticulum membrane] (Homo sapiens)
Activity
lanosterol synthase activity (GO:0000250)
Orthologous Events
Squalene 2,3-epoxide cyclizes, forming lanosterol (Bos taurus)
Squalene 2,3-epoxide cyclizes, forming lanosterol (Canis familiaris)
Squalene 2,3-epoxide cyclizes, forming lanosterol (Danio rerio)
Squalene 2,3-epoxide cyclizes, forming lanosterol (Dictyostelium discoideum)
Squalene 2,3-epoxide cyclizes, forming lanosterol (Gallus gallus)
Squalene 2,3-epoxide cyclizes, forming lanosterol (Mus musculus)
Squalene 2,3-epoxide cyclizes, forming lanosterol (Rattus norvegicus)
Squalene 2,3-epoxide cyclizes, forming lanosterol (Saccharomyces cerevisiae)
Squalene 2,3-epoxide cyclizes, forming lanosterol (Schizosaccharomyces pombe)
Squalene 2,3-epoxide cyclizes, forming lanosterol (Sus scrofa)
Squalene 2,3-epoxide cyclizes, forming lanosterol (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2007-01-24)
Reviewed
D'Eustachio, P  (2007-01-22)
Created
Jassal, B  (2007-01-19)
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