Reactome | FDFT1 [endoplasmic reticulum membrane]

FDFT1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-191369

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Farnesyl-diphosphate farnesyltransferase, farnesyltransferase, presqualene-di-diphosphate synthase, squalene synthase

Locations in the PathwayBrowser for interactor UniProt:Q9H1C4 UNC93B1

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External Reference Information

External Reference

UniProt:P37268 FDFT1

Gene Names

FDFT1

Chain

chain:1-417

Reference Genes

BioGPS Gene:2222 FDFT1

COSMIC (genes):FDFT1 FDFT1

CTD Gene:2222 FDFT1

dbSNP Gene:2222 FDFT1

ENSEMBL:ENSG00000079459 FDFT1

HGNC:3629 FDFT1

KEGG:hsa:2222 FDFT1

Monarch:2222 FDFT1

NCBI Gene:2222 FDFT1

OMIM:184420 FDFT1

UCSC:P37268 FDFT1

Reference Transcript

Other Identifiers

11721242_s_at

11745322_x_at

11748274_s_at

11748275_x_at

11748801_s_at

11754259_x_at

17065811

208647_PM_at

208647_at

210950_PM_s_at

210950_s_at

2222

238666_PM_at

238666_at

3086207

3086208

3086209

3086210

3086211

3086212

3086213

3086214

3086215

3086216

3086217

3086218

3086219

3086220

3086221

3086222

3086223

3086224

3086225

3086226

3086227

3086228

3086230

3086231

3086232

3086234

3086237

3086238

3086239

3086244

3086245

3086246

3086247

3086248

3086249

3086250

3086251

3086252

3086253

34848_at

57523_at

63122_at

8144669

A_14_P129904

A_23_P71319

GE59957

GE78948

GE84819

GE84920

GO:0003824

GO:0004310

GO:0004311

GO:0005515

GO:0005783

GO:0005789

GO:0006629

GO:0006694

GO:0006695

GO:0008610

GO:0009058

GO:0016020

GO:0016740

GO:0016765

GO:0043226

GO:0045338

GO:0046872

GO:0051996

HMNXSV003051665

Hs.191435.0.A1_3p_at

Hs.48876.1.S2_3p_at

ILMN_1741096

ILMN_2144088

PH_hs_0032086

TC08000093.hg

X69141_at

g13097746_3p_a_at

Participates

as an output of

Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)

as a component of

FDFT:Mg2+ [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

fdft1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

erg9 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

FDFT1 [endoplasmic reticulum membrane] (Bos taurus)

FDFT1 [endoplasmic reticulum membrane] (Canis familiaris)

FDFT1 [endoplasmic reticulum membrane] (Gallus gallus)

FDFT1 [endoplasmic reticulum membrane] (Mus musculus)

FDFT1 [endoplasmic reticulum membrane] (Rattus norvegicus)

FDFT1 [endoplasmic reticulum membrane] (Sus scrofa)

ERG9 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

fdfT [endoplasmic reticulum membrane] (Dictyostelium discoideum)

Cross References

Guide to Pharmacology - Targets

645

OpenTargets

ENSG00000079459

ENSEMBL

ENST00000622850, ENSP00000432331, ENSP00000431649, ENSP00000431749, ENSG00000284967, ENST00000647178, ENST00000710780, ENSP00000481481, ENSP00000518480, ENSP00000518483, ENSP00000518482, ENST00000528812, ENST00000710781, ENSG00000079459, ENSP00000390367, ENSP00000495060, ENSP00000484122, ENSP00000220584, ENST00000647069, ENSP00000431852, ENST00000530664, ENSP00000496723, ENST00000530337, ENST00000220584, ENST00000443614, ENSP00000518478, ENST00000528643, ENSP00000518476, ENST00000710775, ENSP00000518477, ENST00000710778, ENST00000710773, ENST00000710774, ENST00000615631

ZINC - FDA approved

FDFT_HUMAN

ZINC - Substances

FDFT_HUMAN

ZINC target

P37268

PRO

P37268

GlyGen

P37268

PDB

3WSA, 3LEE, 3ASX, 3WC9, 8WTQ, 3Q30, 8WTR, 1EZF, 3WEI, 3WEJ, 3WCH, 3VJ8, 3WCI, 3WCD, 3VJ9, 3WEK, 3WCJ, 6PZ5, 3WEF, 3WEG, 6PYW, 3VJA, 3Q2Z, 6PYJ, 3WCF, 6PYV, 3VJB, 3WCL, 3VJC, 3WEH, 3WCM, 3V66

ZINC - Investigational

FDFT_HUMAN

IntEnz

2.5.1.21

GeneCards

FDFT1

HPA

ENSG00000079459-FDFT1

Pharos - Targets

P37268

ZINC - Predictions - Purchasable

FDFT_HUMAN

HMDB Protein

HMDBP00260

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.643	3
UniProt:Q9Y320 TMX2			0.556	3
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3
UniProt:Q9NQQ7-3 Q9NQQ73			0.556	3
UniProt:Q6IBW4-4 NCAPH2			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q96RD7 PANX1	1	PANX1 [plasma membrane] (R-HSA-375344)	0.556	3
UniProt:O43889-2 CREB3			0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:Q96MV1 TLCD4			0.556	3
UniProt:P48165 GJA8	1	GJA8 [endoplasmic reticulum membrane] (R-HSA-190702)	0.556	3
UniProt:P04233-2 CD74			0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:O75503 CLN5			0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q86UX6 ST32C			0.527	2
UniProt:Q8NFA0 UBP32			0.527	2
UniProt:P51575 P2RX1	3	P2RX1 [secretory granule membrane] (R-HSA-6803326) P2RX1 [plasma membrane] (R-HSA-61129) P2RX1 [specific granule membrane] (R-HSA-6803317)	0.527	3
UniProt:Q9UKY4 POMT2	7	POMT2 [endoplasmic reticulum membrane] (R-HSA-5615565) POMT2 Y666C [endoplasmic reticulum membrane] (R-HSA-5617034) POMT2 V373F [endoplasmic reticulum membrane] (R-HSA-5617066) POMT2 I444_N445insLLWQ [endoplasmic reticulum membrane] (R-HSA-5617085) POMT2 T433* [endoplasmic reticulum membrane] (R-HSA-5617041) POMT2 I198N [endoplasmic reticulum membrane] (R-HSA-5617111) POMT2 R638* [endoplasmic reticulum membrane] (R-HSA-5617109)	0.527	2

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