Reactome | LSS [endoplasmic reticulum membrane]

LSS [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-191371

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Lanosterol synthase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P48449 LSS

Gene Names

LSS, OSC

Chain

initiator methionine:, chain:2-732

Reference Genes

BioGPS Gene:4047 LSS

COSMIC (genes):LSS LSS

CTD Gene:4047 LSS

dbSNP Gene:4047 LSS

ENSEMBL:ENSG00000160285 LSS

HGNC:6708 LSS

KEGG:hsa:4047 LSS

Monarch:4047 LSS

NCBI Gene:4047 LSS

OMIM:600909 LSS

UCSC:P48449 LSS

Reference Transcript

Other Identifiers

11717620_a_at

11724199_x_at

11731324_a_at

16926644

202245_PM_at

202245_at

211018_PM_at

211018_at

211019_PM_s_at

211019_s_at

39107_at

39108_at

3935244

3935245

3935246

3935247

3935248

3935249

3935250

3935251

3935252

3935253

3935254

3935255

3935256

3935257

3935258

3935263

3935264

3935265

3935266

3935268

3935270

3935273

3935274

3935275

3935276

3935277

3935278

3935281

3935282

3935283

3935285

3935286

3935287

3935288

3935289

4047

8070961

A_24_P110799

A_24_P162211

A_24_P384839

GE59015

GE86116

GE86424

GO:0000250

GO:0003824

GO:0005515

GO:0005783

GO:0005789

GO:0005811

GO:0006629

GO:0006694

GO:0006695

GO:0016020

GO:0016104

GO:0016853

GO:0016866

GO:0031647

GO:0043226

HMNXSV003011160

HMNXSV003037105

HMNXSV003041282

Hs.93199.0.S2_3p_at

ILMN_1658271

ILMN_1687863

ILMN_1715024

PH_hs_0025849

S81221_at

TC21000554.hg

U22526_at

g1019365_3p_at

Participates

as an output of

Expression of Lanosterol Synthase (LSS) (Homo sapiens)

Inferred To

ERG7 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

cas1 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

lss [endoplasmic reticulum membrane] (Danio rerio)

lss [endoplasmic reticulum membrane] (Xenopus tropicalis)

Lss [endoplasmic reticulum membrane] (Mus musculus)

Lss [endoplasmic reticulum membrane] (Rattus norvegicus)

erg7 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

LSS [endoplasmic reticulum membrane] (Bos taurus)

LSS [endoplasmic reticulum membrane] (Canis familiaris)

LSS [endoplasmic reticulum membrane] (Gallus gallus)

LSS [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2434

OpenTargets

ENSG00000160285

ENSEMBL

ENSP00000380837, ENST00000522411, ENSP00000348762, ENSP00000409191, ENST00000397728, ENST00000457828, ENST00000356396, ENSP00000429133

ZINC - Substances

ERG7_HUMAN

ZINC target

P48449

PRO

P48449

GlyGen

P48449

PDB

1W6J, 1W6K

HPA

ENSG00000160285-LSS

Pharos - Targets

P48449

ZINC - Predictions - Purchasable

ERG7_HUMAN

Orphanet

LSS

HMDB Protein

HMDBP00430

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3
UniProt:Q99828 CIB1			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q9NRX6 KISHB			0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:O00220 TNFRSF10A	1	TNFRSF10A [plasma membrane] (R-HSA-5633393)	0.527	3
UniProt:P09917 ALOX5	6	p-S272-ALOX5 [nuclear envelope] (R-HSA-2318765) ALOX5 [cytosol] (R-HSA-429010) ALOX5 [secretory granule lumen] (R-HSA-6801306) ALOX5 [extracellular region] (R-HSA-6806468) ALOX5 [ficolin-1-rich granule lumen] (R-HSA-6801302) p-S272-ALOX5 [cytosol] (R-HSA-265276)	0.527	2

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