Mevalonate is phosphorylated to mevalonate-5-phosphate

Stable Identifier
R-HSA-191380
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mevalonate is phosphorylated to mevalonate-5-phosphate
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Mevalonate kinase (MK) catalyzes the phosphorylation of mevalonate to mevalonate-5-phosphate.
Literature References
PubMed ID Title Journal Year
1377680 Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria

Mosley, ST, Bishop, RW, Schafer, BL, Kalinowski, SS, Kratunis, VJ, Gibson, KM, Tanaka, RD

J Biol Chem 1992
14730012 Mevalonate kinase is a cytosolic enzyme in humans

Koster, J, Tuyp, JJ, Wanders, RJA, Espeel, M, Waterham, HR, Hogenboom, S

J Cell Sci 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

mevalonate kinase activity of MVK dimer [cytosol]

Physical Entity
MVK dimer [cytosol] (Homo sapiens)
Activity
mevalonate kinase activity (GO:0004496)
Orthologous Events
Mevalonate is phosphorylated to mevalonate-5-phosphate (Bos taurus)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Caenorhabditis elegans)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Canis familiaris)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Danio rerio)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Dictyostelium discoideum)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Drosophila melanogaster)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Gallus gallus)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Mus musculus)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Rattus norvegicus)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Saccharomyces cerevisiae)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Schizosaccharomyces pombe)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Sus scrofa)
Cross References
Rhea
Authored
Jassal, B  (2007-01-24)
Reviewed
D'Eustachio, P  (2007-01-22)
Created
Jassal, B  (2007-01-19)
Cite Us!