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SQLE [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-191395
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Squalene monooxygenase, squalene epoxidase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
Squalene is oxidized to its epoxide (Homo sapiens)
SQLE:FAD [endoplasmic reticulum membrane] (Homo sapiens)
SQLE [endoplasmic reticulum membrane] (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Squalene Monooxygenase (SQLE) (Homo sapiens)
SQLE [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14534 SQLE
Gene Names
SQLE, ERG1
Chain
chain:1-574
Reference Genes
BioGPS Gene:6713 SQLE
COSMIC (genes):SQLE SQLE
CTD Gene:6713 SQLE
dbSNP Gene:6713 SQLE
ENSEMBL:ENSG00000104549 SQLE
HGNC:11279 SQLE
KEGG:hsa:6713 SQLE
Monarch:6713 SQLE
NCBI Gene:6713 SQLE
OMIM:602019 SQLE
UCSC:Q14534 SQLE
Reference Transcript
RefSeq:NM_003129.3 SQLE
Other Identifiers
11717729_a_at
11717730_s_at
11717731_at
11750969_a_at
17072552
209218_PM_at
209218_at
213562_PM_s_at
213562_s_at
213577_PM_at
213577_at
3114835
3114836
3114837
3114838
3114839
3114840
3114841
3114842
3114844
3114845
3114846
3114847
3114849
3114850
3114851
3114852
3114853
3114854
3114855
3114856
3114858
3114859
3114862
3114863
35839_at
3764787
6713
8148280
A_14_P129257
A_23_P146284
D78129_at
GE57294
GO:0003824
GO:0004497
GO:0004506
GO:0005515
GO:0005783
GO:0005789
GO:0006629
GO:0008203
GO:0016020
GO:0016125
GO:0016126
GO:0016491
GO:0042127
GO:0043226
GO:0043231
GO:0050660
GO:0071949
GO:0140042
GO:1904614
HMNXSV003056764
Hs.71465.1.S1_3p_at
Hs.71465.1.S2_3p_a_at
ILMN_1772241
ILMN_2041293
PH_hs_0004140
TC08000729.hg
g4204674_3p_at
Participates
as an output of
Expression of Squalene Monooxygenase (SQLE) (Homo sapiens)
as a component of
SQLE:FAD [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
sqlea [endoplasmic reticulum membrane]
(Danio rerio)
sqle [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
sqle [endoplasmic reticulum membrane]
(Xenopus tropicalis)
SQLE [endoplasmic reticulum membrane]
(Bos taurus)
SQLE [endoplasmic reticulum membrane]
(Canis familiaris)
SQLE [endoplasmic reticulum membrane]
(Gallus gallus)
SQLE [endoplasmic reticulum membrane]
(Mus musculus)
SQLE [endoplasmic reticulum membrane]
(Rattus norvegicus)
SQLE [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
SQLE [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
SQLE [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
ZINC - World Drugs
ERG1_HUMAN
Guide to Pharmacology - Targets
2433
ENSEMBL
ENST00000265896
,
ENSP00000265896
OpenTargets
ENSG00000104549
ZINC - FDA approved
ERG1_HUMAN
ZINC - Substances
ERG1_HUMAN
ZINC target
Q14534
PRO
Q14534
PDB
6C6R
,
6C6P
,
6C6N
ZINC - Investigational
ERG1_HUMAN
HPA
ENSG00000104549-SQLE
Pharos - Targets
Q14534
ZINC - Predictions - Purchasable
ERG1_HUMAN
HMDB Protein
HMDBP00153
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H6H4 REEP4
0.556
3
UniProt:Q9NUH8 TM14B
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q07001 CHRND
1
CHRND [plasma membrane]
(R-HSA-507847)
0.527
2
UniProt:Q96CS3 FAF2
3
FAF2 [cytosol]
(R-HSA-6781921)
FAF2 [extracellular region]
(R-HSA-6806183)
FAF2 [azurophil granule lumen]
(R-HSA-6799138)
0.527
2
UniProt:Q8WWF5 ZNRF4
0.527
2
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