Reduction of presqualene diphosphate to form squalene

Stable Identifier
R-HSA-191402
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
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Reduction of presqualene diphosphate to form squalene
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In the second step, FDFT catalyzes the reduction of presqualene diphosphate to squalene (Pandit et al. 2000).

Literature References
PubMed ID Title Journal Year
10896663 Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.

Danley, DE, Harwood HJ, Jr, Hamanaka, ES, Schulte, GK, Pandit, J, Mazzalupo, S, Pauly, TA, Hayward, CM, Thompson, JF

J Biol Chem 2000
Participants
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Output
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as an event of
Catalyst Activity

farnesyl-diphosphate farnesyltransferase activity of FDFT:Mg2+ [endoplasmic reticulum membrane]

Physical Entity
FDFT:Mg2+ [endoplasmic reticulum membrane] (Homo sapiens)
Activity
farnesyl-diphosphate farnesyltransferase activity (GO:0004310)
Orthologous Events
Reduction of presqualene diphosphate to form squalene (Bos taurus)
Reduction of presqualene diphosphate to form squalene (Canis familiaris)
Reduction of presqualene diphosphate to form squalene (Danio rerio)
Reduction of presqualene diphosphate to form squalene (Dictyostelium discoideum)
Reduction of presqualene diphosphate to form squalene (Gallus gallus)
Reduction of presqualene diphosphate to form squalene (Mus musculus)
Reduction of presqualene diphosphate to form squalene (Rattus norvegicus)
Reduction of presqualene diphosphate to form squalene (Saccharomyces cerevisiae)
Reduction of presqualene diphosphate to form squalene (Schizosaccharomyces pombe)
Reduction of presqualene diphosphate to form squalene (Sus scrofa)
Reduction of presqualene diphosphate to form squalene (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2007-01-24)
Reviewed
D'Eustachio, P  (2007-01-22)
Created
Jassal, B  (2007-01-19)
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