Two FPP molecules dimerize to form presqualene diphosphate

Stable Identifier
R-HSA-191405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Two FPP molecules dimerize to form presqualene diphosphate
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Farnesyl diphosphate farnesyltransferase (FDFT; squalene synthase) catalyzes the reductive dimerization of two farnesyl diphosphate (FPP) molecules to form squalene. This happens in two distinct steps. The first step of dimerization forms presqualene diphosphate (Pandit et al. 2000).
Literature References
PubMed ID Title Journal Year
10896663 Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.

Danley, DE, Harwood HJ, Jr, Hamanaka, ES, Schulte, GK, Pandit, J, Mazzalupo, S, Pauly, TA, Hayward, CM, Thompson, JF

J Biol Chem 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

farnesyl-diphosphate farnesyltransferase activity of FDFT:Mg2+ [endoplasmic reticulum membrane]

Physical Entity
FDFT:Mg2+ [endoplasmic reticulum membrane] (Homo sapiens)
Activity
farnesyl-diphosphate farnesyltransferase activity (GO:0004310)
Orthologous Events
Two FPP molecules dimerize to form presqualene diphosphate (Bos taurus)
Two FPP molecules dimerize to form presqualene diphosphate (Canis familiaris)
Two FPP molecules dimerize to form presqualene diphosphate (Dictyostelium discoideum)
Two FPP molecules dimerize to form presqualene diphosphate (Gallus gallus)
Two FPP molecules dimerize to form presqualene diphosphate (Mus musculus)
Two FPP molecules dimerize to form presqualene diphosphate (Rattus norvegicus)
Two FPP molecules dimerize to form presqualene diphosphate (Saccharomyces cerevisiae)
Two FPP molecules dimerize to form presqualene diphosphate (Schizosaccharomyces pombe)
Two FPP molecules dimerize to form presqualene diphosphate (Sus scrofa)
Two FPP molecules dimerize to form presqualene diphosphate (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2007-01-24)
Reviewed
D'Eustachio, P  (2007-01-22)
Created
Jassal, B  (2007-01-19)
Cite Us!