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L1CAM [plasma membrane]
Stable Identifier
R-HSA-191465
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
L1, Neural cell adhesion molecule L1, CAML_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Cis-heterodimerization of L1 and Axonin-1 (Homo sapiens)
L1:Axonin-1 [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Cis-heterodimerization of L1 and Contactin-1/F3/F11 (Homo sapiens)
L1:CNTN1 [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN (Homo sapiens)
L1:ALCAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Heat-Stable Antigen binds L1 (Homo sapiens)
L1:HSA [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Interaction between L1 and Ankyrins (Homo sapiens)
L1 dimer binds Ankyrin (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)
L1 dimer:Ankyrin:Spectrin:F-actin [plasma membrane] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of Y1229 in L1 (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
pL1 (Y1229):L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Interaction of L1 with Laminin-1 (Homo sapiens)
L1:HNK-1 [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1:Laminin [plasma membrane] (Homo sapiens)
L1:HNK-1 [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Interaction of L1 with Neurocan (Homo sapiens)
L1:Neurocan [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 binds RanBPM (Homo sapiens)
L1:RanBPM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by EPHB2 (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Recycling pathway of L1 (Homo sapiens)
Dephosphorylation of pL1 (Y1176) (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
pL1:ERM:F-actin [plasma membrane] (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Formation of clathrin coated vesicle (Homo sapiens)
L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1:clathrin-coated vesicle [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Interaction of NUMB with L1 (Homo sapiens)
L1:NUMB:CRMP-2:alpha-adaptin [clathrin-coated endocytic vesicle] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 binds to AP-2 Clathrin complex (Homo sapiens)
L1:clathrin-coated vesicle [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 trans-homophilic interaction (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Linkage of L1 with treadmilling F-actin (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
pL1:ERM:F-actin [plasma membrane] (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by ERK (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by SRC (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by p90rsk (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Reinsertion of L1 into the plasma membrane (Homo sapiens)
AP2 clathrin:L1:KIF4:microtubule [cytosol] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Transport of L1 from C-domain to P-domain (Homo sapiens)
AP2 clathrin:L1:KIF4:microtubule [cytosol] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Transport of L1 into endosomes (Homo sapiens)
L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Signal transduction by L1 (Homo sapiens)
L1 and NCAM1 engaged in cis-interaction (Homo sapiens)
L1:NCAM1 complex [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 binds NRP1 (Homo sapiens)
L1:NRP1 [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 interaction with Integrins (Homo sapiens)
L1:Integrin complex [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1-EGFR trans-heterodimerization (Homo sapiens)
L1-EGFR trans-heterodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1-FGFR cis-heterodimerization (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1:FGFR1 [plasma membrane] (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by CK-II (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Basigin interactions (Homo sapiens)
Basigin binds Mannose-carrying cell recognition molecules (Homo sapiens)
Basigin:Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32004 L1CAM
Gene Names
L1CAM, CAML1, MIC5
Chain
signal peptide:1-19, chain:20-1257
Reference Genes
BioGPS Gene:3897 L1CAM
COSMIC (genes):L1CAM L1CAM
CTD Gene:3897 L1CAM
dbSNP Gene:3897 L1CAM
ENSEMBL:ENSG00000198910 L1CAM
HGNC:6470 L1CAM
KEGG:hsa:3897 L1CAM
Monarch:3897 L1CAM
NCBI Gene:3897 L1CAM
OMIM:308840 L1CAM
UCSC:P32004 L1CAM
Reference Transcript
RefSeq:NM_001278116.1 L1CAM
RefSeq:NM_024003.3 L1CAM
RefSeq:NM_000425.4 L1CAM
RefSeq:NM_001143963.2 L1CAM
Other Identifiers
11724578_at
11724579_a_at
17115271
204584_PM_at
204584_at
204585_PM_s_at
204585_s_at
38551_at
3897
4026799
4026800
4026801
4026804
4026805
4026806
4026807
4026808
4026809
4026810
4026811
4026812
4026813
4026814
4026815
4026816
4026817
4026818
4026819
4026820
4026821
4026822
4026823
4026824
4026825
4026826
4026827
4026828
4026829
4026830
4026831
4026832
4026833
4026834
4026835
4026838
4026839
4026840
4026841
8175871
A_23_P171324
A_24_P207995
A_33_P3374443
GE570016
GE62364
GO:0005515
GO:0005886
GO:0005925
GO:0006935
GO:0007155
GO:0007156
GO:0007160
GO:0007399
GO:0007411
GO:0008046
GO:0009986
GO:0016477
GO:0019904
GO:0030154
GO:0030312
GO:0030424
GO:0030425
GO:0030426
GO:0031012
GO:0031175
GO:0034330
GO:0042995
GO:0043025
GO:0044295
GO:0045773
GO:0048856
GO:0048870
GO:0050808
GO:0060089
GO:0061564
GO:0062023
HMNXSV003007167
Hs.1757.0.S3_3p_at
ILMN_1739238
ILMN_2362341
PH_hs_0026029
TC0X002307.hg
U52112_rna1_at
g13435354_3p_a_at
Participates
as a component of
L1:Neurocan [plasma membrane] (Homo sapiens)
L1:NCAM1 complex [plasma membrane] (Homo sapiens)
L1:Integrin complex [plasma membrane] (Homo sapiens)
L1-EGFR trans-heterodimer [plasma membrane] (Homo sapiens)
L1:NRP1 [plasma membrane] (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
pL1 (Y1229):L1CAM [plasma membrane] (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
L1:ALCAM [plasma membrane] (Homo sapiens)
L1:HNK-1 [plasma membrane] (Homo sapiens)
L1:CNTN1 [plasma membrane] (Homo sapiens)
L1:NUMB:CRMP-2:alpha-adaptin [clathrin-coated endocytic vesicle] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Homo sapiens)
L1:clathrin-coated vesicle [plasma membrane] (Homo sapiens)
L1:RanBPM [plasma membrane] (Homo sapiens)
L1:HSA [plasma membrane] (Homo sapiens)
L1:Axonin-1 [plasma membrane] (Homo sapiens)
as an input of
Interaction of L1 with Neurocan (Homo sapiens)
L1 and NCAM1 engaged in cis-interaction (Homo sapiens)
L1 interaction with Integrins (Homo sapiens)
L1-EGFR trans-heterodimerization (Homo sapiens)
Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN (Homo sapiens)
Cis-heterodimerization of L1 and Contactin-1/F3/F11 (Homo sapiens)
Phosphorylation of L1 by EPHB2 (Homo sapiens)
Interaction of NUMB with L1 (Homo sapiens)
L1 trans-homophilic interaction (Homo sapiens)
Phosphorylation of L1 by SRC (Homo sapiens)
L1 binds to AP-2 Clathrin complex (Homo sapiens)
Phosphorylation of L1 by p90rsk (Homo sapiens)
L1 binds RanBPM (Homo sapiens)
Heat-Stable Antigen binds L1 (Homo sapiens)
Cis-heterodimerization of L1 and Axonin-1 (Homo sapiens)
Phosphorylation of L1 by CK-II (Homo sapiens)
L1 binds NRP1 (Homo sapiens)
as an output of
Reinsertion of L1 into the plasma membrane (Homo sapiens)
Dephosphorylation of pL1 (Y1176) (Homo sapiens)
as a member of
Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-S1181-L1CAM [plasma membrane]
p-S1204,S1248-L1CAM [plasma membrane]
p-S1152-L1CAM [plasma membrane]
p-Y-L1CAM [plasma membrane]
p-Y1176-L1CAM [plasma membrane]
p-Y1229-L1CAM [plasma membrane]
Inferred To
Ghost homologue of L1CAM [plasma membrane]
(Bos taurus)
Ghost homologue of L1CAM [plasma membrane]
(Canis familiaris)
Ghost homologue of L1CAM [plasma membrane]
(Dictyostelium discoideum)
Ghost homologue of L1CAM [plasma membrane]
(Drosophila melanogaster)
Ghost homologue of L1CAM [plasma membrane]
(Gallus gallus)
Ghost homologue of L1CAM [plasma membrane]
(Saccharomyces cerevisiae)
Ghost homologue of L1CAM [plasma membrane]
(Schizosaccharomyces pombe)
Ghost homologue of L1CAM [plasma membrane]
(Sus scrofa)
ncam2 [plasma membrane]
(Xenopus tropicalis)
wrk-1 [plasma membrane]
(Caenorhabditis elegans)
L1cam [plasma membrane]
(Mus musculus)
L1cam [plasma membrane]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000359077
,
ENSP00000354712
,
ENST00000370055
,
ENSP00000359072
,
ENSP00000355380
,
ENST00000361981
,
ENST00000361699
,
ENST00000370060
OpenTargets
ENSG00000198910
HPA
ENSG00000198910-L1CAM
PRO
P32004
Pharos - Targets
P32004
GlyGen
P32004
Orphanet
L1CAM
PDB
8AFO
,
8AFP
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ChEBI:61048 GANGLIOSIDE
0.556
3
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