Reactome | FRS3 [plasma membrane]

FRS3 [plasma membrane]

Stable Identifier

R-HSA-191482

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FRS2-beta

Locations in the PathwayBrowser for interactor UniProt:Q8IWL8 STH

Expand all

External Reference Information

External Reference

UniProt:O43559 FRS3

Gene Names

FRS3

Chain

initiator methionine:, chain:2-492

Reference Genes

BioGPS Gene:10817 FRS3

COSMIC (genes):FRS3 FRS3

CTD Gene:10817 FRS3

dbSNP Gene:10817 FRS3

ENSEMBL:ENSG00000137218 FRS3

HGNC:16970 FRS3

KEGG:hsa:10817 FRS3

Monarch:10817 FRS3

NCBI Gene:10817 FRS3

OMIM:607744 FRS3

UCSC:O43559 FRS3

Reference Transcript

Other Identifiers

10817

11727216_at

17019121

219907_PM_at

219907_at

2953778

2953779

2953780

2953781

2953782

2953783

2953784

2953786

2953787

2953788

2953790

2953791

8126337

83768_at

A_23_P167970

A_33_P3270295

GE62391

GO:0005068

GO:0005104

GO:0005515

GO:0005737

GO:0005886

GO:0007165

GO:0008543

GO:0016020

GO:0042802

GO:0060090

HMNXSV003013050

ILMN_1772605

PH_hs_0011463

TC06001723.hg

g5730058_3p_at

Participates

as a member of

as a component of

as an input of

Other forms of this molecule

p-5Y-FRS3 [plasma membrane]

p-Y-FRS3 [plasma membrane]

Inferred To

Frs3 [plasma membrane] (Mus musculus)

Frs3 [plasma membrane] (Rattus norvegicus)

Dmel\CG13398 [plasma membrane] (Drosophila melanogaster)

frs3 [plasma membrane] (Danio rerio)

frs3 [plasma membrane] (Xenopus tropicalis)

FRS3 [plasma membrane] (Bos taurus)

FRS3 [plasma membrane] (Canis familiaris)

FRS3 [plasma membrane] (Gallus gallus)

FRS3 [plasma membrane] (Sus scrofa)

Ghost homologue of FRS3 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011512557.1, NP_006644.1, XP_011512556.1

OpenTargets

ENSG00000137218

ENSEMBL

ENSP00000362109, ENST00000259748, ENSP00000259748, ENST00000373018

HPA

ENSG00000137218-FRS3

PRO

O43559

Pharos - Targets

O43559

GlyGen

O43559

PDB

2YS5, 2YT2, 2KUQ, 2KUP

Interactors (106)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8HWS3 RFX6	1	RFX6 [nucleoplasm] (R-HSA-8931801)	0.718	6
UniProt:Q15654 TRIP6			0.718	6
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.703	5
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.57	3
UniProt:Q9WMX2-PRO_0000037548			0.57	3
UniProt:Q9H079 KTBL1			0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q8WVV4-1 POF1B			0.556	3
UniProt:Q9UFD9 RIM3A			0.556	3
UniProt:Q02363 ID2	1	ID2 [nucleoplasm] (R-HSA-452391)	0.556	3
UniProt:P27658 COL8A1	20	3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173246) GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173055) 3x4Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173183) 3x4Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173195) 3x4Hyp-3Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173270) GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173122) GalHyl-COL8A1(28-744) [extracellular region] (R-HSA-2192737) 3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [extracellular region] (R-HSA-2192736) COL8A1(28-744) [extracellular region] (R-HSA-2192738) 5Hyl-COL8A1(28-744) [extracellular region] (R-HSA-2192741) 3x4Hyp-3Hyp-COL8A1(28-744) [extracellular region] (R-HSA-2192740) 3x4Hyp-GlcGalHyl-COL8A1(28-744) [extracellular region] (R-HSA-2192743) 3x4Hyp-3Hyp-GlcGalHyl-COL8A1(28-744) [extracellular region] (R-HSA-2192742) 3x4Hyp-COL8A1(?-744) [extracellular region] (R-HSA-2192733) 3x4Hyp-3Hyp-5Hyl-COL8A1(28-744) [extracellular region] (R-HSA-2192732) 3x4Hyp-GalHyl-COL8A1(28-744) [extracellular region] (R-HSA-2192748) GlcGalHyl-COL8A1(28-744) [extracellular region] (R-HSA-2192735) 3x4Hyp-5Hyl-COL8A1(28-744) [extracellular region] (R-HSA-2192750) 3x4Hyp-GlcGalHyl-COL8A1(28-?) [extracellular region] (R-HSA-2470341) GlcGalHyl-COL8A1(?-744) [extracellular region] (R-HSA-2470373)	0.556	3
UniProt:Q6ZU52 K0408			0.556	3
UniProt:Q9BYR7 KRTAP3-2	1	KRTAP3-2 [cytosol] (R-HSA-6809857)	0.556	3
UniProt:A8MV65-2 VGLL3			0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
UniProt:Q8NEC5 CATSPER1	1	CATSPER1 [plasma membrane] (R-HSA-2534335)	0.556	3
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q3KP44 ANR55			0.556	3
UniProt:Q9NR12 PDLIM7	1	PDLIM7 [cytosol] (R-HSA-8855085)	0.556	3
UniProt:Q02535 ID3	1	ID3 [nucleoplasm] (R-HSA-9613379)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q8TF47 ZFP90	1	ZFP90 [nucleoplasm] (R-HSA-974988)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q08117-2 TLE5			0.556	5
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:P15976 GATA1	1	GATA1 [nucleoplasm] (R-HSA-996772)	0.556	3
UniProt:Q9NWS9-2 ZNF446			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q9UC07-2 ZNF69			0.556	3
UniProt:O43597 SPRY2	8	p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) SPRY2 [cytosol] (R-HSA-182949) SPRY2 [plasma membrane] (R-HSA-182924) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-Y55-SPRY2 [cytosol] (R-HSA-182950)	0.556	3
UniProt:Q5BKX5-3 ACTMAP			0.556	3
UniProt:Q8WWB5 PIHD2			0.556	3
UniProt:O75716 STK16			0.556	3
UniProt:Q9NYG5-2 ANAPC11			0.556	3
UniProt:Q6NVV7 CDPF1			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	5
UniProt:A2VCK2 DCD2B			0.556	3
UniProt:Q01546 KRT76	1	KRT76 [cytosol] (R-HSA-6809633)	0.556	3
UniProt:Q8IWL8 STH			0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:Q9Y6H3 ATP23			0.556	3
IntAct:EBI-22320813 CCSB ORF ID			0.556	3
UniProt:Q8NF64-3 ZMIZ2			0.556	3
UniProt:Q8ND83 SLAI1			0.556	3
UniProt:Q86WV8 Q86WV8			0.556	3
UniProt:P48745 CCN3			0.556	3
UniProt:Q9UNS2 COPS3	2	COPS3 [nucleoplasm] (R-HSA-5697017) COPS3 [cytosol] (R-HSA-416973)	0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	5
UniProt:P15976-2 GATA1			0.556	5
UniProt:Q8N1D0-2 SLC22A18AS			0.556	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	5
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
UniProt:Q9H707 ZNF552	1	ZNF552 [nucleoplasm] (R-HSA-1973877)	0.556	3
UniProt:Q8N456 LRC18			0.556	3
UniProt:Q8TAV5 KC5S1			0.556	3
UniProt:O14817 TSN4			0.556	3
UniProt:Q9NQL9 DMRT3			0.556	3
UniProt:Q6P5X5 CV039			0.556	3
UniProt:Q96FE5 LINGO1	1	LINGO1 [plasma membrane] (R-HSA-3006563)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:Q8WWY6 MB3L1			0.556	3
UniProt:Q02930-3 CREB5			0.556	3
UniProt:Q9H5F2 CFA68			0.556	3
UniProt:Q7Z4V0 ZN438			0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	7
UniProt:Q86W11 ZSC30			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q8NA61 CBY2			0.556	3
UniProt:Q7Z6I5 SPT12			0.556	3
UniProt:Q6P1J6-2 PLB1			0.556	3
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.556	3
UniProt:O15162 PLS1			0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:A0A0U1RQF7 DP2NB			0.556	3
UniProt:Q9Y342 PLLP			0.556	3
UniProt:Q96PF1 TGM7			0.556	3
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.556	3
UniProt:Q9H9P5-5 UNKL			0.556	3
UniProt:Q15973 ZNF124	1	ZNF124 [nucleoplasm] (R-HSA-975017)	0.556	3
UniProt:Q92824-2 PCSK5			0.556	3
UniProt:Q8TDR4 TCP1L			0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:P35452-2 P354522			0.556	3
UniProt:Q6IA69 NADSYN1	1	NADSYN1 [cytosol] (R-HSA-197231)	0.556	3
UniProt:Q8IUC1 KRTAP11-1	1	KRTAP11-1 [cytosol] (R-HSA-6810294)	0.556	3
UniProt:Q16610 ECM1	2	ECM1 [extracellular region] (R-HSA-8848909) ECM1 [platelet dense granule lumen] (R-HSA-8848880)	0.556	3
UniProt:Q5JXC2 MIIP			0.556	3
UniProt:Q9ULR0-1 Q9ULR01			0.556	3
UniProt:Q9NQ30 ESM1			0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.508	2
UniProt:P08631-2 HCK			0.508	2
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.488	2
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.488	2
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.488	2

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