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2xMe-SNRPD3 [cytosol]
Stable Identifier
R-HSA-191781
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
dimethylated Sm protein D3, SMD3_HUMAN, snRNP core protein D3, Small nuclear ribonucleoprotein Sm D3, Sm-D3
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 modulates host translation machinery (Homo sapiens)
snRNP complex assembly (Homo sapiens)
SMN:SM protein complex [cytosol] (Homo sapiens)
snRNP Sm core complex [cytosol] (Homo sapiens)
2xMe-SNRPD3 [cytosol] (Homo sapiens)
Spliceosomal m7G capped snRNAs with SMN:SM protein complex bound [cytosol] (Homo sapiens)
SMN:SM protein complex [cytosol] (Homo sapiens)
snRNP Sm core complex [cytosol] (Homo sapiens)
2xMe-SNRPD3 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Metabolism of non-coding RNA (Homo sapiens)
snRNP Assembly (Homo sapiens)
Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)
2xMe-SNRPD3 [cytosol] (Homo sapiens)
SMN:SM protein complex [cytosol] (Homo sapiens)
snRNP Sm core complex [cytosol] (Homo sapiens)
2xMe-SNRPD3 [cytosol] (Homo sapiens)
snRNA Cap hypermethylation (Homo sapiens)
Spliceosomal m3G capped snRNAs with SMN:SM protein complex bound [cytosol] (Homo sapiens)
SMN:SM protein complex [cytosol] (Homo sapiens)
snRNP Sm core complex [cytosol] (Homo sapiens)
2xMe-SNRPD3 [cytosol] (Homo sapiens)
Spliceosomal m7G capped snRNAs with SMN:SM protein complex bound [cytosol] (Homo sapiens)
SMN:SM protein complex [cytosol] (Homo sapiens)
snRNP Sm core complex [cytosol] (Homo sapiens)
2xMe-SNRPD3 [cytosol] (Homo sapiens)
snRNP complex assembly (Homo sapiens)
SMN:SM protein complex [cytosol] (Homo sapiens)
snRNP Sm core complex [cytosol] (Homo sapiens)
2xMe-SNRPD3 [cytosol] (Homo sapiens)
Spliceosomal m7G capped snRNAs with SMN:SM protein complex bound [cytosol] (Homo sapiens)
SMN:SM protein complex [cytosol] (Homo sapiens)
snRNP Sm core complex [cytosol] (Homo sapiens)
2xMe-SNRPD3 [cytosol] (Homo sapiens)
snRNP nuclear import and release (Homo sapiens)
Spliceosomal m3G capped snRNA:SMN:SM:Snurportin complex [cytosol] (Homo sapiens)
SMN:SM protein complex [cytosol] (Homo sapiens)
snRNP Sm core complex [cytosol] (Homo sapiens)
2xMe-SNRPD3 [cytosol] (Homo sapiens)
snRNP:Snurportin complex formation (Homo sapiens)
Spliceosomal m3G capped snRNA:SMN:SM:Snurportin complex [cytosol] (Homo sapiens)
SMN:SM protein complex [cytosol] (Homo sapiens)
snRNP Sm core complex [cytosol] (Homo sapiens)
2xMe-SNRPD3 [cytosol] (Homo sapiens)
Spliceosomal m3G capped snRNAs with SMN:SM protein complex bound [cytosol] (Homo sapiens)
SMN:SM protein complex [cytosol] (Homo sapiens)
snRNP Sm core complex [cytosol] (Homo sapiens)
2xMe-SNRPD3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62318 SNRPD3
Gene Names
SNRPD3
Chain
initiator methionine:, chain:2-126
Reference Genes
BioGPS Gene:6634 SNRPD3
COSMIC (genes):SNRPD3 SNRPD3
CTD Gene:6634 SNRPD3
dbSNP Gene:6634 SNRPD3
ENSEMBL:ENSG00000100028 SNRPD3
HGNC:11160 SNRPD3
KEGG:hsa:6634 SNRPD3
Monarch:6634 SNRPD3
NCBI Gene:6634 SNRPD3
OMIM:601062 SNRPD3
UCSC:P62318 SNRPD3
Reference Transcript
RefSeq:NM_001278656.1 SNRPD3
RefSeq:NM_004175.4 SNRPD3
Other Identifiers
11717431_a_at
16928282
202567_PM_at
202567_at
3940189
3940190
3940191
3940192
3940193
3940194
3940195
3940196
3940198
3940199
3940200
3940201
3940202
3940203
3940204
3940205
3940206
3940207
3940208
3940212
40150_at
44100_at
63879_at
6634
77648_at
8071920
A_14_P114019
A_23_P132216
A_33_P3314511
A_33_P3396239
GE61234
GE87971
GO:0000243
GO:0000387
GO:0000398
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005681
GO:0005682
GO:0005683
GO:0005684
GO:0005685
GO:0005686
GO:0005687
GO:0005689
GO:0005697
GO:0005737
GO:0005829
GO:0006396
GO:0006397
GO:0006479
GO:0008380
GO:0016071
GO:0016604
GO:0019899
GO:0030532
GO:0034709
GO:0034715
GO:0034719
GO:0036261
GO:0043226
GO:0046540
GO:0065003
GO:0070034
GO:0071005
GO:0071007
GO:0071011
GO:0071013
GO:0071208
GO:0071209
GO:0097526
GO:1903241
GO:1990446
HMNXSV003039054
HMNXSV003044545
ILMN_1794599
PH_hs_0024004
TC22001459.hg
U15009_at
g4759159_3p_at
Participates
as an input of
Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)
as a component of
snRNP Sm core complex [cytosol] (Homo sapiens)
Other forms of this molecule
2xMe-SNRPD3 [nucleoplasm]
SNRPD3 [nucleoplasm]
Inferred To
snrpD3 [cytosol]
(Dictyostelium discoideum)
2xMe-SNRPD3 [cytosol]
(Bos taurus)
2xMe-SNRPD3 [cytosol]
(Plasmodium falciparum)
LOC102152884 [cytosol]
(Canis familiaris)
snrpd3 [cytosol]
(Xenopus tropicalis)
snr-1 [cytosol]
(Caenorhabditis elegans)
Snrpd3 [cytosol]
(Mus musculus)
Snrpd3 [cytosol]
(Rattus norvegicus)
smd3 [cytosol]
(Schizosaccharomyces pombe)
SNRPD3 [cytosol]
(Gallus gallus)
SNRPD3 [cytosol]
(Sus scrofa)
snrpd3l [cytosol]
(Danio rerio)
SMD3 [cytosol]
(Saccharomyces cerevisiae)
SmD3 [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
monomethylated residue at unknown position
PsiMod Name
monomethylated residue [MOD:00599]
PsiMod Definition
A protein modification that effectively replaces one hydrogen atom with one methyl group.
Name
monomethylated residue at unknown position
PsiMod Name
monomethylated residue [MOD:00599]
PsiMod Definition
A protein modification that effectively replaces one hydrogen atom with one methyl group.
Cross References
RefSeq
NP_001265585.1
,
NP_004166.1
OpenTargets
ENSG00000100028
ENSEMBL
ENSP00000215829
,
ENST00000402849
,
ENSP00000385266
,
ENST00000215829
HPA
ENSG00000100028-SNRPD3
PRO
P62318
Pharos - Targets
P62318
GlyGen
P62318
PDB
5XJC
,
7EVO
,
7W5B
,
8H6E
,
8Y6O
,
6AHD
,
5Z57
,
5Z56
,
6ICZ
,
6ID1
,
8Q7X
,
3CW1
,
6QW6
,
7B0Y
,
8R09
,
5Z58
,
7W5A
,
7VPX
,
3PGW
,
8Y7E
,
8Q7Q
,
8RM5
,
3VRI
,
6QX9
,
5YZG
,
8Q91
,
1D3B
,
4WZJ
,
8H6L
,
8H6J
,
8C6J
,
6V4X
,
6FF7
,
3JCR
,
7W59
,
8CH6
,
6Y5Q
,
8QO9
,
8HK1
,
8Q7W
,
6QDV
,
7ABI
,
7A5P
,
8R0B
,
7ABG
,
8QXD
,
5MQF
,
8Q7V
,
8R0A
,
8R08
,
5O9Z
,
6Y53
,
6ID0
,
6AH0
,
7QTT
,
4PJO
,
7DVQ
,
8RC0
,
8H6K
,
8QZS
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54105 CLNS1A
1
CLNS1A [cytosol]
(R-HSA-191796)
0.906
11
UniProt:P14678 SNRPB
4
2xMe-SNRPB [cytosol]
(R-HSA-192218)
SNRPB [cytosol]
(R-HSA-191798)
Me2-R108,R112-SNRPB [nucleoplasm]
(R-HSA-192213)
SNRPB [nucleoplasm]
(R-HSA-71896)
0.88
8
UniProt:P62310 LSM3
2
LSM3 [nucleoplasm]
(R-HSA-6806807)
LSM3 [cytosol]
(R-HSA-429894)
0.742
5
UniProt:Q9UK45 LSM7
2
LSM7 [cytosol]
(R-HSA-2028610)
LSM7 [nucleoplasm]
(R-HSA-6806802)
0.668
3
UniProt:P08621 SNRNP70
1
SNRNP70 [nucleoplasm]
(R-HSA-71913)
0.643
6
UniProt:P62306 SNRPF
2
SNRPF [cytosol]
(R-HSA-191852)
SNRPF [nucleoplasm]
(R-HSA-71907)
0.643
3
UniProt:Q8TEQ6 GEMIN5
2
GEMIN5 [cytosol]
(R-HSA-191833)
GEMIN5 [nucleoplasm]
(R-HSA-191765)
0.643
3
UniProt:Q8WWY3 PRPF31
1
PRPF31 [nucleoplasm]
(R-HSA-6806772)
0.638
3
UniProt:P84090 ERH
0.576
3
UniProt:Q15428 SF3A2
1
SF3A2 [nucleoplasm]
(R-HSA-71964)
0.564
2
UniProt:P08579 SNRPB2
1
SNRPB2 [nucleoplasm]
(R-HSA-71960)
0.564
3
UniProt:Q96SB4 SRPK1
2
SRPK1 [nucleoplasm]
(R-HSA-9821984)
SRPK1 [cytosol]
(R-HSA-9729349)
0.564
2
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:P54253 ATX1
0.556
3
UniProt:P62308 SNRPG
2
SNRPG [cytosol]
(R-HSA-191827)
SNRPG [nucleoplasm]
(R-HSA-71909)
0.547
2
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.536
3
UniProt:O60306 AQR
1
AQR [nucleoplasm]
(R-HSA-6781960)
0.528
2
UniProt:P63162 SNRPN
1
Me2-R108,R112-SNRPN [nucleoplasm]
(R-HSA-8865931)
0.527
3
UniProt:P62316 SNRPD2
2
SNRPD2 [cytosol]
(R-HSA-191810)
SNRPD2 [nucleoplasm]
(R-HSA-71901)
0.527
2
UniProt:P09661 SNRPA1
1
SNRPA1 [nucleoplasm]
(R-HSA-71958)
0.527
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
2
UniProt:P09234 SNRPC
1
SNRPC [nucleoplasm]
(R-HSA-8865876)
0.527
3
UniProt:P62304 SNRPE
2
SNRPE [cytosol]
(R-HSA-191782)
SNRPE [nucleoplasm]
(R-HSA-71905)
0.527
4
UniProt:P09012 SNRPA
1
SNRPA [nucleoplasm]
(R-HSA-71915)
0.527
2
UniProt:Q9Y6A4 CFA20
0.508
2
UniProt:P14678-2 SNRPB
0.499
2
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