Reactome | SNRPE [cytosol]

SNRPE [cytosol]

Stable Identifier

R-HSA-191782

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Sm protein E, snRNP E, RUXE_HUMAN, Small nuclear ribonucleoprotein E, snRNP-E, Sm-E, SmE

Locations in the PathwayBrowser for interactor UniProt:Q96GM8 TOE1

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External Reference Information

External Reference

UniProt:P62304 SNRPE

Gene Names

SNRPE

Chain

chain:1-92

Reference Genes

BioGPS Gene:6635 SNRPE

COSMIC (genes):SNRPE SNRPE

CTD Gene:6635 SNRPE

dbSNP Gene:6635 SNRPE

ENSEMBL:ENSG00000182004 SNRPE

ENSEMBL_homo_sapiens_GENE:ENSG00000182004.13 SNRPE

HGNC:11161 SNRPE

KEGG Gene (Homo sapiens):6635 SNRPE

Monarch:6635 SNRPE

NCBI Gene:6635 SNRPE

OMIM:128260 SNRPE

UCSC:P62304 SNRPE

Reference Transcript

Other Identifiers

11718040_x_at

11718041_at

203316_PM_s_at

203316_s_at

231112_PM_at

231112_at

2375878

2375879

2375884

2375886

2375888

2375889

2375890

2375891

2375892

2375894

2978642

3198044

3847247

3847251

38678_at

38679_g_at

6635

7908988

8160033

82273_at

A_23_P126291

A_33_P3244424

GE87544

GO:0000245

GO:0000387

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005682

GO:0005683

GO:0005684

GO:0005685

GO:0005686

GO:0005687

GO:0005689

GO:0005697

GO:0005737

GO:0005829

GO:0006397

GO:0008380

GO:0016071

GO:0030532

GO:0034709

GO:0034715

GO:0034719

GO:0036261

GO:0043226

GO:0043229

GO:0046540

GO:0065003

GO:0071005

GO:0071007

GO:0071011

GO:0071013

GO:1903241

GO:1990904

HMNXSV003030680

Hs.1066.1.A1_3p_at

ILMN_1656424

ILMN_2046199

M21259_at

PH_hs_0029773

PH_hs_0038261

TC01001693.hg

TC19001078.hg

g4507128_3p_a_at

g4507128_3p_x_at

Participates

as an input of

Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)

as a component of

snRNP Sm core complex [cytosol] (Homo sapiens)

Other forms of this molecule

SNRPE [nucleoplasm]

Inferred To

snrpe [cytosol] (Danio rerio)

snr-6 [cytosol] (Caenorhabditis elegans)

Homologues of SNRPE [cytosol] (Bos taurus)

SNRPE [cytosol] (Bos taurus)

SNRPE [cytosol] (Canis familiaris)

SNRPE [cytosol] (Gallus gallus)

SNRPE [cytosol] (Plasmodium falciparum)

SNRPE [cytosol] (Sus scrofa)

Ghost homologue of SNRPE [cytosol] (Xenopus tropicalis)

SME1 [cytosol] (Saccharomyces cerevisiae)

SmE [cytosol] (Drosophila melanogaster)

snrpE [cytosol] (Dictyostelium discoideum)

sme1 [cytosol] (Schizosaccharomyces pombe)

Snrpe [cytosol] (Mus musculus)

Snrpe [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001315566.1, NP_001291393.1, NP_001315567.1, NP_003085.1

OpenTargets

ENSG00000182004

HPA

ENSG00000182004-SNRPE

GeneCards

P62304

Ensembl

ENSP00000400591, ENSG00000182004, ENST00000414487

PRO

P62304

Pharos - Targets

P62304

Orphanet

21748

PDB

8CH6, 5Z57, 5YZG, 8RC0, 6V4X, 5XJS, 7ABG, 6Y53, 5XJT, 7EVO, 6QW6, 4F7U, 8Q7Q, 8C6J, 5XJC, 6QDV, 5O9Z, 3JCR, 7W5A, 6ID0, 7B0Y, 7A5P, 6ID1, 6Y5Q, 5Z56, 7W5B, 8Q7V, 6QX9, 3PGW, 5XJQ, 5Z58, 8QO9, 8Y7E, 7ABI, 7DVQ, 5XJR, 8Q91, 5XJU, 6AH0, 4V98, 8HK1, 8Y6O, 7QTT, 7W59, 6FF7, 5MQF, 3CW1, 8Q7W, 6ICZ, 4WZJ, 4PJO, 5XJL, 7VPX, 8Q7X

Interactors (85)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62306 SNRPF	2	SNRPF [nucleoplasm] (R-HSA-71907) SNRPF [cytosol] (R-HSA-191852)	0.93	14
UniProt:P62308 SNRPG	2	SNRPG [nucleoplasm] (R-HSA-71909) SNRPG [cytosol] (R-HSA-191827)	0.869	11
UniProt:P14678 SNRPB	4	SNRPB [nucleoplasm] (R-HSA-71896) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [cytosol] (R-HSA-191798) 2xMe-SNRPB [cytosol] (R-HSA-192218)	0.793	7
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.773	8
UniProt:Q9Y333 LSM2	2	LSM2 [nucleoplasm] (R-HSA-71894) LSM2 [cytosol] (R-HSA-429849)	0.745	5
UniProt:P62316 SNRPD2	2	SNRPD2 [nucleoplasm] (R-HSA-71901) SNRPD2 [cytosol] (R-HSA-191810)	0.744	6
UniProt:Q9Y4Y9 LSM5	2	LSM5 [cytosol] (R-HSA-429839) LSM5 [nucleoplasm] (R-HSA-6806795)	0.743	5
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [cytosol] (R-HSA-191833) GEMIN5 [nucleoplasm] (R-HSA-191765)	0.708	6
UniProt:O14893 GEMIN2	2	GEMIN2 [nucleoplasm] (R-HSA-191795) GEMIN2 [cytosol] (R-HSA-191835)	0.708	7
UniProt:Q8WXD5 GEMIN6	2	GEMIN6 [nucleoplasm] (R-HSA-191799) GEMIN6 [cytosol] (R-HSA-191771)	0.688	5
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.669	5
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [cytosol] (R-HSA-192217)	0.669	5
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.648	5
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.643	5
UniProt:P08579 SNRPB2	1	SNRPB2 [nucleoplasm] (R-HSA-71960)	0.643	5
UniProt:P08621 SNRNP70	1	SNRNP70 [nucleoplasm] (R-HSA-71913)	0.643	7
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.643	5
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.643	5
UniProt:O95400 CD2BP2	1	CD2BP2 [nucleoplasm] (R-HSA-72054)	0.643	5
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.643	5
UniProt:Q9Y3B4 SF3B6	1	SF3B6 [nucleoplasm] (R-HSA-83808)	0.643	4
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.643	5
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.643	5
UniProt:O95149 SNUPN	1	SNUPN [cytosol] (R-HSA-191857)	0.643	5
UniProt:P14678-2 SNRPB			0.623	3
UniProt:Q9Y4Z0 LSM4	2	LSM4 [nucleoplasm] (R-HSA-6806804) LSM4 [cytosol] (R-HSA-429956)	0.547	2
UniProt:P62310 LSM3	2	LSM3 [nucleoplasm] (R-HSA-6806807) LSM3 [cytosol] (R-HSA-429894)	0.547	2
UniProt:P83369 LSM11	1	LSM11 [nucleoplasm] (R-HSA-110760)	0.527	4
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.527	3
UniProt:P57678 GEMIN4	2	GEMIN4 [nucleoplasm] (R-HSA-191841) GEMIN4 [cytosol] (R-HSA-191836)	0.527	4
UniProt:Q96LT9 RNPC3	1	RNPC3 [nucleoplasm] (R-HSA-6787844)	0.527	4
UniProt:Q9BWJ5 SF3B5	1	SF3B5 [nucleoplasm] (R-HSA-71979)	0.527	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	4
UniProt:Q7L014 DDX46	1	DDX46 [nucleoplasm] (R-HSA-5688096)	0.527	2
UniProt:Q96DI7 SNRNP40	1	SNRNP40 [nucleoplasm] (R-HSA-71877)	0.527	4
UniProt:Q7L2J0 MEPCE			0.527	4
UniProt:Q9UHI6 DDX20	2	DDX20 [nucleoplasm] (R-HSA-191847) DDX20 [cytosol] (R-HSA-191838)	0.527	4
UniProt:Q86UT8 CATAC			0.527	3
UniProt:A8MWD9 RUXGL			0.527	2
UniProt:Q6IEG0 SNRNP48	1	SNRNP48 [nucleoplasm] (R-HSA-6787849)	0.527	4
UniProt:Q96DF8 ESS2			0.527	2
UniProt:Q15020 SART3			0.527	4
UniProt:Q9BWU0 NADAP			0.527	4
UniProt:Q9UDW3 ZMAT5	1	ZMAT5 [nucleoplasm] (R-HSA-6787850)	0.527	2
UniProt:O95926 SYF2	1	SYF2 [nucleoplasm] (R-HSA-8867884)	0.527	4
UniProt:Q96NB3 ZNF830	1	ZNF830 [nucleoplasm] (R-HSA-6781962)	0.527	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.527	4
UniProt:Q6P2Q9 PRPF8	1	PRPF8 [nucleoplasm] (R-HSA-83810)	0.527	4
UniProt:Q9H6E5 STPAP			0.527	4
UniProt:Q8N954 GPT11			0.527	3
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.527	4
UniProt:Q8IYT2 CMTR2			0.527	3
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.527	3
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.527	4
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.527	3
UniProt:P62312 LSM6	2	LSM6 [cytosol] (R-HSA-429936) LSM6 [nucleoplasm] (R-HSA-6806794)	0.527	2
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	4
UniProt:Q9Y5B6 PAXB1			0.527	4
UniProt:Q8N8D1 PDCD7	1	PDCD7 [nucleoplasm] (R-HSA-6787851)	0.527	4
UniProt:Q96RS0 TGS1	2	TGS1 [cytosol] (R-HSA-192209) TGS1 [nucleoplasm] (R-HSA-400176)	0.527	4
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.527	2
UniProt:Q96GM8 TOE1			0.527	4
UniProt:Q9NWZ8 GEMIN8	2	GEMIN8 [nucleoplasm] (R-HSA-8932892) GEMIN8 [cytosol] (R-HSA-8932878)	0.527	4
UniProt:O75643 SNRNP200	1	SNRNP200 [nucleoplasm] (R-HSA-71885)	0.527	4
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.527	4
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.527	4
UniProt:Q56P03 EAPP			0.527	4
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.527	4
UniProt:Q12874 SF3A3	1	SF3A3 [nucleoplasm] (R-HSA-71966)	0.527	4
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.527	4
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.527	4
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	4
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.527	3
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.527	4
UniProt:Q9H875 PRKRIP1	1	PRKRIP1 [nucleoplasm] (R-HSA-9769594)	0.527	2
UniProt:P62318 SNRPD3	3	SNRPD3 [nucleoplasm] (R-HSA-71903) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219) 2xMe-SNRPD3 [cytosol] (R-HSA-191781)	0.527	4
UniProt:Q9H5Z1 DHX35	1	DHX35 [nucleoplasm] (R-HSA-9770427)	0.527	4
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.527	4
UniProt:P16383 GCFC2	1	GCFC2 [nucleoplasm] (R-HSA-8869311)	0.527	2
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.527	2
UniProt:O43719 HTATSF1	1	HTATSF1 [nucleoplasm] (R-HSA-9770246)	0.527	4
UniProt:Q8WUD4 CCDC12	1	CCDC12 [nucleoplasm] (R-HSA-9769561)	0.527	4
UniProt:Q9BRR8 GPATCH1	1	GPATCH1 [nucleoplasm] (R-HSA-9770419)	0.527	4
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.527	4
UniProt:O60508 CDC40	1	CDC40 [nucleoplasm] (R-HSA-72062)	0.527	4

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