Reactome | SNRPB [cytosol]

SNRPB [cytosol]

Stable Identifier

R-HSA-191798

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Sm Protein B, Small nuclear ribonucleoprotein associated proteins B and B', snRNP-B, Sm protein B/B', Sm-B/Sm-B', SmB/SmB'

Locations in the PathwayBrowser for interactor UniProt:Q96GM8 TOE1

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External Reference Information

External Reference

UniProt:P14678 SNRPB

Gene Names

SNRPB, COD, SNRPB1

Chain

chain:1-240

Reference Genes

BioGPS Gene:6628 SNRPB

COSMIC (genes):SNRPB SNRPB

CTD Gene:6628 SNRPB

dbSNP Gene:6628 SNRPB

ENSEMBL:ENSG00000125835 SNRPB

ENSEMBL_homo_sapiens_GENE:ENSG00000125835.20 SNRPB

HGNC:11153 SNRPB

KEGG Gene (Homo sapiens):6628 SNRPB

Monarch:6628 SNRPB

NCBI Gene:6628 SNRPB

OMIM:182282 SNRPB

UCSC:P14678 SNRPB

Reference Transcript

Other Identifiers

11720935_a_at

11736675_a_at

11754105_x_at

11757344_x_at

11757660_a_at

11757661_x_at

11760170_x_at

16916546

208821_PM_at

208821_at

213175_PM_s_at

213175_s_at

38455_at

38456_s_at

3894999

3895000

3895001

3895002

3895004

3895005

3895006

3895011

3895017

3895020

3895021

6628

8064502

A_23_P154675

GE81233

GE85808

GO:0000387

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005682

GO:0005683

GO:0005684

GO:0005685

GO:0005686

GO:0005687

GO:0005689

GO:0005697

GO:0005737

GO:0005829

GO:0006397

GO:0006479

GO:0008380

GO:0016071

GO:0030532

GO:0034709

GO:0034719

GO:0036211

GO:0036261

GO:0043226

GO:0046540

GO:0065003

GO:0070034

GO:0071004

GO:0071005

GO:0071007

GO:0071013

GO:0071204

GO:0071208

GO:1903241

GO:1990446

GO:1990447

GO:1990904

HMNXSV003058451

Hs.83753.1.S1_3p_s_at

ILMN_1774661

ILMN_1799103

PH_hs_0029017

PH_hs_0035482

TC20001744.hg

X17567_s_at

X52979_rna1_s_at

g190246_3p_at

Participates

as an input of

Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)

Other forms of this molecule

SNRPB [nucleoplasm]

Me2-R108,R112-SNRPB [nucleoplasm]

2xMe-SNRPB [cytosol]

Inferred To

SmB [cytosol] (Drosophila melanogaster)

SMB1 [cytosol] (Saccharomyces cerevisiae)

snr-2 [cytosol] (Caenorhabditis elegans)

Homologues of SNRPB [cytosol] (Bos taurus)

SNRPN [cytosol] (Bos taurus)

SNRPN [cytosol] (Sus scrofa)

snrpb [cytosol] (Danio rerio)

snrpb [cytosol] (Dictyostelium discoideum)

snrpb [cytosol] (Xenopus tropicalis)

SNRPB [cytosol] (Bos taurus)

SNRPB [cytosol] (Canis familiaris)

SNRPB [cytosol] (Gallus gallus)

SNRPB [cytosol] (Plasmodium falciparum)

Snrpb [cytosol] (Mus musculus)

Snrpb [cytosol] (Rattus norvegicus)

smb1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_937859.1, NP_003082.1

OpenTargets

ENSG00000125835

GeneCards

P14678

HPA

ENSG00000125835-SNRPB

Ensembl

ENSG00000125835, ENST00000381342, ENST00000438552, ENSP00000412566, ENSP00000370746

PRO

P14678

Pharos - Targets

P14678

Orphanet

23011

PDB

4PJO, 7W59, 6AH0, 3JCR, 3CW1, 8Q7Q, 8C6J, 7QTT, 5MQF, 8HK1, 4WZJ, 7W5A, 6QDV, 8Y6O, 7DVQ, 7ABG, 7EVO, 6V4X, 6FF7, 7ABI, 6Y53, 8RC0, 3PGW, 8Q91, 6QW6, 5Z56, 7A5P, 6ICZ, 6ID1, 8CH6, 6QX9, 8Y7E, 6ID0, 8QO9, 8Q7V, 1D3B, 7W5B, 5XJC, 5Z58, 6Y5Q, 5O9Z, 8Q7W, 5YZG, 5Z57, 7VPX, 8Q7X

Interactors (77)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95400 CD2BP2	1	CD2BP2 [nucleoplasm] (R-HSA-72054)	0.882	11
UniProt:P62318 SNRPD3	3	SNRPD3 [nucleoplasm] (R-HSA-71903) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219) 2xMe-SNRPD3 [cytosol] (R-HSA-191781)	0.88	8
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.801	6
UniProt:P57678 GEMIN4	2	GEMIN4 [nucleoplasm] (R-HSA-191841) GEMIN4 [cytosol] (R-HSA-191836)	0.8	5
UniProt:P62316 SNRPD2	2	SNRPD2 [nucleoplasm] (R-HSA-71901) SNRPD2 [cytosol] (R-HSA-191810)	0.793	7
UniProt:P62304 SNRPE	2	SNRPE [nucleoplasm] (R-HSA-71905) SNRPE [cytosol] (R-HSA-191782)	0.793	7
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [cytosol] (R-HSA-192217)	0.793	5
UniProt:P62306 SNRPF	2	SNRPF [nucleoplasm] (R-HSA-71907) SNRPF [cytosol] (R-HSA-191852)	0.793	7
UniProt:P08621 SNRNP70	1	SNRNP70 [nucleoplasm] (R-HSA-71913)	0.784	8
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.768	7
UniProt:P62308 SNRPG	2	SNRPG [nucleoplasm] (R-HSA-71909) SNRPG [cytosol] (R-HSA-191827)	0.734	5
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.725	5
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.723	6
UniProt:Q15020 SART3			0.669	4
UniProt:O75643 SNRNP200	1	SNRNP200 [nucleoplasm] (R-HSA-71885)	0.669	4
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.669	3
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.669	4
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.669	3
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.669	4
UniProt:O43719 HTATSF1	1	HTATSF1 [nucleoplasm] (R-HSA-9770246)	0.669	4
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.648	4
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [cytosol] (R-HSA-191833) GEMIN5 [nucleoplasm] (R-HSA-191765)	0.643	4
UniProt:Q9Y3F4 STRAP	1	STRAP [cytosol] (R-HSA-2127556)	0.59	2
UniProt:P38432 COIL			0.564	2
UniProt:P54253 ATX1			0.556	3
UniProt:O95777 LSM8	1	LSM8 [nucleoplasm] (R-HSA-6806779)	0.547	2
UniProt:Q9Y333 LSM2	2	LSM2 [nucleoplasm] (R-HSA-71894) LSM2 [cytosol] (R-HSA-429849)	0.547	2
UniProt:Q96LT9 RNPC3	1	RNPC3 [nucleoplasm] (R-HSA-6787844)	0.527	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	4
UniProt:O14893 GEMIN2	2	GEMIN2 [nucleoplasm] (R-HSA-191795) GEMIN2 [cytosol] (R-HSA-191835)	0.527	2
UniProt:P08579 SNRPB2	1	SNRPB2 [nucleoplasm] (R-HSA-71960)	0.527	5
UniProt:Q9BWJ5 SF3B5	1	SF3B5 [nucleoplasm] (R-HSA-71979)	0.527	2
UniProt:O43172 PRPF4	1	PRPF4 [nucleoplasm] (R-HSA-71890)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	4
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.527	2
UniProt:Q96DI7 SNRNP40	1	SNRNP40 [nucleoplasm] (R-HSA-71877)	0.527	3
UniProt:Q9UHI6 DDX20	2	DDX20 [nucleoplasm] (R-HSA-191847) DDX20 [cytosol] (R-HSA-191838)	0.527	2
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.527	2
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.527	3
UniProt:Q6IEG0 SNRNP48	1	SNRNP48 [nucleoplasm] (R-HSA-6787849)	0.527	2
UniProt:Q9BWU0 NADAP			0.527	3
UniProt:Q86VM9 ZCH18			0.527	2
UniProt:Q8WXD5 GEMIN6	2	GEMIN6 [nucleoplasm] (R-HSA-191799) GEMIN6 [cytosol] (R-HSA-191771)	0.527	2
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.527	2
UniProt:Q9BZJ0 CRNKL1	1	CRNKL1 [nucleoplasm] (R-HSA-8867899)	0.527	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.527	3
UniProt:Q6P2Q9 PRPF8	1	PRPF8 [nucleoplasm] (R-HSA-83810)	0.527	3
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	3
UniProt:Q8N954 GPT11			0.527	2
UniProt:Q8IYT2 CMTR2			0.527	3
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.527	3
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.527	4
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.527	2
UniProt:P62312 LSM6	2	LSM6 [cytosol] (R-HSA-429936) LSM6 [nucleoplasm] (R-HSA-6806794)	0.527	2
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	4
UniProt:Q9Y5B6 PAXB1			0.527	2
UniProt:P83876 TXNL4A	1	TXNL4A [nucleoplasm] (R-HSA-71875)	0.527	2
UniProt:Q96RS0 TGS1	2	TGS1 [cytosol] (R-HSA-192209) TGS1 [nucleoplasm] (R-HSA-400176)	0.527	2
UniProt:Q96GM8 TOE1			0.527	3
UniProt:Q9NWZ8 GEMIN8	2	GEMIN8 [nucleoplasm] (R-HSA-8932892) GEMIN8 [cytosol] (R-HSA-8932878)	0.527	3
UniProt:Q56P03 EAPP			0.527	3
UniProt:Q9UK45 LSM7	2	LSM7 [nucleoplasm] (R-HSA-6806802) LSM7 [cytosol] (R-HSA-2028610)	0.527	2
UniProt:Q9Y312 AAR2			0.527	2
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.527	3
UniProt:Q12874 SF3A3	1	SF3A3 [nucleoplasm] (R-HSA-71966)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.527	2
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.527	2
UniProt:Q13523 PRPF4B	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.527	2
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.527	2
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.527	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.527	2
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.527	3
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.527	2
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.527	3
UniProt:O60508 CDC40	1	CDC40 [nucleoplasm] (R-HSA-72062)	0.527	2

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