Reactome | CHIP (STUB1) mediates ubiquitination of ERBB2

CHIP (STUB1) mediates ubiquitination of ERBB2

Stable Identifier

R-HSA-1918092

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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CHIP (STUB1) mediates ubiquitination of ERBB2

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E3 ubiquitin ligase CHIP (STUB1) mediates ERBB2 ubiquitination by associating with the ERBB2 indirectly, through the chaperone protein HSP90. CHIP (STUB1) ubiquitinates both ERBB2 and HSP90, leading to their proteasome-dependent degradation. Ubiquitination of ERBB2 by CHIP (STUB1) is independent of ERBB2 activation.

Literature References

PubMed ID	Title	Journal	Year
12239347	Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu Mimnaugh, E, Yuan, X, Neckers, LM, Marcu, M, Xu, W, Patterson, C	Proc Natl Acad Sci U S A	2002