CUL5 mediates ubiquitination of ERBB2

Stable Identifier
R-HSA-1918095
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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CUL5 mediates ubiquitination of ERBB2
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E3 ubiquitin ligase Cullin-5 (CUL5) is recruited to the ERBB2 site at the plasma membrane and ubiquitinates ERBB2 in an HSP90-dependent way, targeting it for degradation. Ubiquitination of ERBB2 by CUL5 appears to be independent of CUL5 adaptor proteins ElonginB and ElonginC.

Literature References
PubMed ID Title Journal Year
19933325 Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

Yu, XF, Luo, K, Xiao, Z, Neckers, LM, Martinez, T, Xu, W, Wang, T, Ehrlich, ES, Niewiadomska, AM

Proc Natl Acad Sci U S A 2009
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of CUL5 [cytosol]

Physical Entity
CUL5 [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
CUL5 mediates ubiquitination of ERBB2 (Bos taurus)
CUL5 mediates ubiquitination of ERBB2 (Caenorhabditis elegans)
CUL5 mediates ubiquitination of ERBB2 (Canis familiaris)
CUL5 mediates ubiquitination of ERBB2 (Danio rerio)
CUL5 mediates ubiquitination of ERBB2 (Drosophila melanogaster)
CUL5 mediates ubiquitination of ERBB2 (Gallus gallus)
CUL5 mediates ubiquitination of ERBB2 (Mus musculus)
CUL5 mediates ubiquitination of ERBB2 (Rattus norvegicus)
CUL5 mediates ubiquitination of ERBB2 (Sus scrofa)
CUL5 mediates ubiquitination of ERBB2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-11-02)
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