Reactome | GEMIN2 [cytosol]

GEMIN2 [cytosol]

Stable Identifier

R-HSA-191835

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Gemin 2

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 modulates host translation machinery (Homo sapiens)
        
        snRNP complex assembly (Homo sapiens)
        
        SMN:SM protein complex [cytosol] (Homo sapiens)
        
        SMN complex [cytosol] (Homo sapiens)
        
        GEMIN2 [cytosol] (Homo sapiens)
        
        Spliceosomal m7G capped snRNAs with SMN:SM protein complex bound [cytosol] (Homo sapiens)
        
        SMN:SM protein complex [cytosol] (Homo sapiens)
        
        SMN complex [cytosol] (Homo sapiens)
        
        GEMIN2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14893 GEMIN2

Gene Names

GEMIN2, SIP1

Chain

chain:1-280

Reference Genes

BioGPS Gene:8487 GEMIN2

COSMIC (genes):GEMIN2 GEMIN2

CTD Gene:8487 GEMIN2

dbSNP Gene:8487 GEMIN2

ENSEMBL:ENSG00000092208 GEMIN2

ENSEMBL_homo_sapiens_GENE:ENSG00000092208.19 GEMIN2

HGNC:10884 GEMIN2

KEGG Gene (Homo sapiens):8487 GEMIN2

Monarch:8487 GEMIN2

NCBI Gene:8487 GEMIN2

OMIM:602595 GEMIN2

UCSC:O14893 GEMIN2

Reference Transcript

Other Identifiers

11728886_s_at

11728887_x_at

11741695_a_at

11742300_a_at

11753472_a_at

16783623

17123164

205063_PM_at

205063_at

210779_PM_x_at

210779_x_at

211114_PM_x_at

211114_x_at

211115_PM_x_at

211115_x_at

3533399

3533400

3533401

3533402

3533403

3533404

3533405

3533407

3533410

3533411

3533414

3533415

3533419

3533420

41363_at

7974054

8487

A_23_P88194

A_33_P3297155

GE54212

GO:0000245

GO:0000375

GO:0000387

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005730

GO:0005737

GO:0005829

GO:0006397

GO:0008380

GO:0016071

GO:0016604

GO:0032797

GO:0034719

GO:0043226

GO:0065003

GO:0097504

GO:1905215

HMNXSV003012628

ILMN_2344002

ILMN_2344007

PH_hs_0005680

TC14000247.hg

g4506960_3p_x_at

g9650992_3p_a_at

Participates

as a component of

SMN complex [cytosol] (Homo sapiens)

Other forms of this molecule

GEMIN2 [nucleoplasm]

Inferred To

GEMIN2 [cytosol] (Bos taurus)

GEMIN2 [cytosol] (Canis familiaris)

GEMIN2 [cytosol] (Gallus gallus)

GEMIN2 [cytosol] (Sus scrofa)

smi-1 [cytosol] (Caenorhabditis elegans)

Gemin2 [cytosol] (Mus musculus)

Gemin2 [cytosol] (Rattus norvegicus)

sip1 [cytosol] (Danio rerio)

gemin2 [cytosol] (Dictyostelium discoideum)

gemin2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001009183.1, NP_001009182.1, NP_003607.1

OpenTargets

ENSG00000092208

HPA

ENSG00000092208-GEMIN2

GeneCards

O14893

Ensembl

ENST00000308317, ENSG00000092208, ENSP00000308533

PRO

O14893

Pharos - Targets

O14893

PDB

5XJS, 5XJL, 5XJQ, 5XJR, 5XJT, 5XJU, 2LEH

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62306 SNRPF	2	SNRPF [nucleoplasm] (R-HSA-71907) SNRPF [cytosol] (R-HSA-191852)	0.786	11
UniProt:P62316 SNRPD2	2	SNRPD2 [nucleoplasm] (R-HSA-71901) SNRPD2 [cytosol] (R-HSA-191810)	0.623	4
UniProt:P62308 SNRPG	2	SNRPG [nucleoplasm] (R-HSA-71909) SNRPG [cytosol] (R-HSA-191827)	0.623	4
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [cytosol] (R-HSA-192217)	0.623	4
UniProt:P62304 SNRPE	2	SNRPE [nucleoplasm] (R-HSA-71905) SNRPE [cytosol] (R-HSA-191782)	0.623	4
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3