Reactome | PRMT5 [cytosol]

PRMT5 [cytosol]

Stable Identifier

R-HSA-191876

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

JBP1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O14744 PRMT5

Gene Names

PRMT5, HRMT1L5, IBP72, JBP1, SKB1

Chain

initiator methionine:1, chain:1-637, chain:2-637

Reference Genes

BioGPS Gene:10419 PRMT5

COSMIC (genes):PRMT5 PRMT5

CTD Gene:10419 PRMT5

dbSNP Gene:10419 PRMT5

ENSEMBL:ENSG00000100462 PRMT5

ENSEMBL:ENSG00000100462.16 PRMT5

HGNC:10894 PRMT5

KEGG Gene (Homo sapiens):10419 PRMT5

Monarch:10419 PRMT5

NCBI Gene:10419 PRMT5

OMIM:604045 PRMT5

UCSC:O14744 PRMT5

Reference Transcript

Other Identifiers

10419

11755951_s_at

1564520_PM_s_at

1564520_s_at

1564521_PM_x_at

1564521_x_at

16790556

217786_PM_at

217786_at

3556925

3556926

3556927

3556928

3556929

3556931

3556934

3556935

3556937

3556938

3556939

3556940

3556941

3556942

3556943

3556945

3556946

3556948

3556950

3556952

3556953

3556954

3556955

3556956

3556957

3556958

3556959

3556960

56550_at

57340_s_at

7977820

AF015913_at

A_23_P76851

A_24_P298420

GE61958

GO:0000278

GO:0000387

GO:0000785

GO:0002039

GO:0003677

GO:0003714

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005794

GO:0005829

GO:0006325

GO:0006338

GO:0006351

GO:0006353

GO:0006355

GO:0006479

GO:0007088

GO:0008168

GO:0008276

GO:0008327

GO:0008469

GO:0016071

GO:0016274

GO:0016740

GO:0018216

GO:0023052

GO:0030154

GO:0032259

GO:0032922

GO:0032991

GO:0034709

GO:0034969

GO:0035097

GO:0035243

GO:0035246

GO:0036211

GO:0042118

GO:0042802

GO:0043021

GO:0043226

GO:0043985

GO:0044020

GO:0044030

GO:0044877

GO:0045596

GO:0045892

GO:0046982

GO:0048026

GO:0048511

GO:0048714

GO:0048856

GO:0065003

GO:0070372

GO:0070888

GO:0090161

GO:0097421

GO:0140014

GO:0140096

GO:0140110

GO:1901796

GO:1904992

HMNXSV003013590

ILMN_1811955

ILMN_2403889

PH_hs_0017523

TC14000940.hg

g5174682_3p_at

g5174682_3p_s_at

Participates

as a component of

Methylosome [cytosol] (Homo sapiens)

Other forms of this molecule

p-Y297,304,307-PRMT5 [nucleoplasm]

PRMT5 [nucleoplasm]

Inferred To

PRMT5 [cytosol] (Bos taurus)

PRMT5 [cytosol] (Danio rerio)

PRMT5 [cytosol] (Mus musculus)

PRMT5 [cytosol] (Sus scrofa)

Prmt5 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001034708.1, NP_001269882.1, NP_001269885.1, NP_001269884.1, NP_006100.2

Guide to Pharmacology - Targets

1256

OpenTargets

ENSG00000100462

ZINC - Substances

ANM5_HUMAN

ZINC target

O14744

PRO

O14744

PDB

5EMM, 7BOC, 7U30, 7UYF, 8CSG, 7L1G, 7S1Q, 7MXC, 7SES, 7MXA, 6UGH, 4GQB, 7S1R, 7MXG, 8CTB, 7UY1, 7MXN, 5EML, 5EMK, 7ZUU, 5FA5, 6RLQ, 7MX7, 6UXX, 7ZV2, 6V0P, 7SER, 7ZUY, 6UXY, 5C9Z, 7UOH, 7S1P, 7KIB, 7KIC, 4X60, 7S1S, 6K1S, 7M05, 6CKC, 7ZUP, 7ZVL, 4X61, 6RLL, 5EMJ, 7KID, 4X63, 6V0O, 7BO7, 7ZUQ, 7ZVU, 7S0U, 6V0N

IntEnz

2.1.1.320

HPA

ENSG00000100462-PRMT5

GeneCards

O14744

Ensembl

ENST00000324366, ENSP00000319169, ENSP00000216350, ENST00000553897, ENSP00000452555, ENSG00000100462, ENST00000216350, ENSP00000380583, ENST00000397441, ENSP00000380582, ENST00000397440

Pharos - Targets

O14744

ZINC - Predictions - Purchasable

ANM5_HUMAN

HMDB Protein

HMDBP01721

Interactors (50)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.96	17
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.777	8
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.756	6
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.693	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.666	4
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.646	8
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.646	3
UniProt:Q86U06 RBM23			0.635	3
UniProt:Q91XC0 Ajuba	3	Ajuba [nucleoplasm] (R-MMU-5687969) phospho-Ajuba [cytosol] (R-MMU-2574841) Ajuba [cytosol] (R-MMU-2564698)	0.623	4
UniProt:Q9BRS2 RIOK1	2	RIOK1 [cytosol] (R-HSA-6791525) RIOK1 [nucleoplasm] (R-HSA-5226890)	0.623	5
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.616	6
UniProt:O75044 SRGAP2	1	SRGAP2 [cytosol] (R-HSA-195131)	0.611	4
UniProt:Q9Y6K1 DNMT3A	2	monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415) DNMT3A [nucleoplasm] (R-HSA-212287)	0.602	4
UniProt:Q9Y5B0 CTDP1	1	CTDP1 [nucleoplasm] (R-HSA-113416)	0.591	3
UniProt:P24928 POLR2A	7	p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) POLR2A [nucleoplasm] (R-HSA-63502) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100)	0.558	6
UniProt:Q9NX04 CA109			0.556	3
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [cytosol] (R-HSA-390464) CCT2 [azurophil granule lumen] (R-HSA-6799356)	0.556	3
UniProt:O15197-2 EPHB6			0.556	3
UniProt:Q14241 ELOA	1	TCEB3 [nucleoplasm] (R-HSA-112421)	0.556	3
UniProt:P31930 UQCRC1	1	UQCRC1 [mitochondrial inner membrane] (R-HSA-164284)	0.556	3
UniProt:P40337-2 VHL			0.556	3
UniProt:Q96E35 ZMY19			0.556	3
UniProt:Q08289 CACNB2	2	CACNB2 [plasma membrane] (R-HSA-532200) CACNB2 [cytosol] (R-HSA-210496)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q8WUW1 BRK1	1	BRK1 [cytosol] (R-HSA-1671645)	0.556	3
UniProt:P21964-2 COMT			0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:P03952 KLKB1	5	KLKB1(20-390) [extracellular region] (R-HSA-158239) KLKB1(391-638) [extracellular region] (R-HSA-158181) KLKB1(20-638) [plasma membrane] (R-HSA-158385) KLKB1(20-390) [plasma membrane] (R-HSA-158213) KLKB1(391-638) [plasma membrane] (R-HSA-158277)	0.556	3
UniProt:Q00613 HSF1	11	p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) HSF1 [cytosol] (R-HSA-3371452)	0.556	3
UniProt:P06858 LPL	1	LPL [extracellular region] (R-HSA-174605)	0.556	3
UniProt:P01019 AGT	9	AGT(36-41) [cytosol] (R-HSA-8852193) AGT(35-41) [cytosol] (R-HSA-8852195) AGT(36-41) [extracellular region] (R-HSA-2022355) AGT(35-41) [extracellular region] (R-HSA-2022354) AGT(34-40) [extracellular region] (R-HSA-2022351) AGT(34-42) [extracellular region] (R-HSA-2022348) AGT [extracellular region] (R-HSA-1998759) AGT(34-43) [extracellular region] (R-HSA-2022346) AGT(34-41) [extracellular region] (R-HSA-374187)	0.556	3
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.556	3
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q86UQ8-1 NFE4			0.525	2
UniProt:P31269 HXA9			0.524	4
UniProt:Q8WVJ2 NUDC2			0.508	2
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [extracellular region] (R-HSA-8863001) GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960)	0.508	2
UniProt:Q8TE85 GRHL3			0.508	2
UniProt:Q8N8U2 CDYL2			0.508	2
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.508	2
UniProt:P03418 N	1	p-N [cytosol] (R-RSY-9823348)	0.499	2
UniProt:Q16526 CRY1	4	Ub-p-S-CRY1 [nucleoplasm] (R-HSA-517931) CRY1 [cytosol] (R-HSA-400247) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270)	0.499	3
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.462	2
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.462	3

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