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Synthesis of bile acids and bile salts
Stable Identifier
R-HSA-192105
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
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In a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily (Russell 2003). The major pathway for bile salt synthesis in the liver begins with the conversion of cholesterol to 7alpha-hydroxycholesterol. Bile salt synthesis can also begin with the synthesis of an oxysterol - 24-hydroxycholesterol or 27-hydroxycholesterol. In the body, the initial steps of these two pathways occur in extrahepatic tissues, generating intermediates that are transported to the liver and converted to bile salts via the 7alpha-hydroxycholesterol pathway. These extrahepatic pathways contribute little to the total synthesis of bile salts, but are thought to play important roles in cholesterol homeostasis (Javitt 2002).
Literature References
PubMed ID
Title
Journal
Year
11969205
Cholesterol, hydroxycholesterols, and bile acids
Javitt, NB
Biochem Biophys Res Commun
2002
12543708
The enzymes, regulation, and genetics of bile acid synthesis
Russell, DW
Annu Rev Biochem
2003
Participants
Events
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
(Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(Homo sapiens)
Cholesterol is hydroxylated to 25-hydroxycholesterol
(Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL
(Homo sapiens)
OSBPs transport 25OH-CHOL from ER membrane to plasma membrane
(Homo sapiens)
OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane
(Homo sapiens)
Participates
as an event of
Bile acid and bile salt metabolism (Homo sapiens)
Event Information
Go Biological Process
bile acid biosynthetic process (0006699)
Orthologous Events
Synthesis of bile acids and bile salts (Bos taurus)
Synthesis of bile acids and bile salts (Caenorhabditis elegans)
Synthesis of bile acids and bile salts (Canis familiaris)
Synthesis of bile acids and bile salts (Danio rerio)
Synthesis of bile acids and bile salts (Dictyostelium discoideum)
Synthesis of bile acids and bile salts (Drosophila melanogaster)
Synthesis of bile acids and bile salts (Gallus gallus)
Synthesis of bile acids and bile salts (Mus musculus)
Synthesis of bile acids and bile salts (Plasmodium falciparum)
Synthesis of bile acids and bile salts (Rattus norvegicus)
Synthesis of bile acids and bile salts (Saccharomyces cerevisiae)
Synthesis of bile acids and bile salts (Schizosaccharomyces pombe)
Synthesis of bile acids and bile salts (Sus scrofa)
Synthesis of bile acids and bile salts (Xenopus tropicalis)
Authored
Jassal, B (2007-01-19)
Reviewed
D'Eustachio, P (2007-04-30)
Created
Jassal, B (2007-01-26)
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