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CYP7B1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-192117
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 7B1, CP7B_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
Cytochrome P450 (CYP7A1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP7B1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP7B1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP7B1 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)
Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP7B1 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
Cytochrome P450 (CYP7A1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP7B1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75881 CYP7B1
Gene Names
CYP7B1
Chain
chain:1-506
Reference Genes
BioGPS Gene:9420 CYP7B1
COSMIC (genes):CYP7B1 CYP7B1
CTD Gene:9420 CYP7B1
dbSNP Gene:9420 CYP7B1
ENSEMBL:ENSG00000172817 CYP7B1
HGNC:2652 CYP7B1
KEGG:hsa:9420 CYP7B1
Monarch:9420 CYP7B1
NCBI Gene:9420 CYP7B1
OMIM:603711 CYP7B1
UCSC:O75881 CYP7B1
Reference Transcript
RefSeq:NM_004820.4 CYP7B1
Other Identifiers
11740151_at
17077723
207386_PM_at
207386_at
235438_PM_at
235438_at
3138201
3138203
3138205
3138206
3138207
3138208
3138209
3138211
3138218
3138219
3138220
3138221
3138223
3138246
3138247
3138248
3138249
3138270
33055_at
8151056
82933_at
9420
A_23_P169092
GE58345
GO:0002376
GO:0003824
GO:0004497
GO:0005506
GO:0005515
GO:0005783
GO:0005789
GO:0006629
GO:0006694
GO:0006699
GO:0008203
GO:0008396
GO:0016020
GO:0016125
GO:0016491
GO:0016705
GO:0020037
GO:0022414
GO:0030520
GO:0033147
GO:0033782
GO:0033783
GO:0035754
GO:0042632
GO:0043226
GO:0046872
GO:0048870
GO:0050673
GO:0050679
GO:0060740
GO:1901615
HMNXSV003025384
Hs.146226.0.A1_3p_at
ILMN_1701661
PH_hs_0008586
TC08001275.hg
g13787190_3p_at
Participates
as a candidate of
Cytochrome P450 (CYP7A1 based) [endoplasmic reticulum membrane] (Homo sapiens)
as a member of
Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
CYP7B1 Y275* [endoplasmic reticulum membrane]
CYP7B1 T297A [endoplasmic reticulum membrane]
CYP7B1 F216S [endoplasmic reticulum membrane]
CYP7B1 G87V [endoplasmic reticulum membrane]
CYP7B1 F470I [endoplasmic reticulum membrane]
CYP7B1 S363F [endoplasmic reticulum membrane]
CYP7B1 G57R [endoplasmic reticulum membrane]
CYP7B1 R417H [endoplasmic reticulum membrane]
CYP7B1 R388* [endoplasmic reticulum membrane]
Inferred To
CYP7B1 [endoplasmic reticulum membrane]
(Bos taurus)
CYP7B1 [endoplasmic reticulum membrane]
(Canis familiaris)
CYP7B1 [endoplasmic reticulum membrane]
(Gallus gallus)
CYP7B1 [endoplasmic reticulum membrane]
(Mus musculus)
CYP7B1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP7B1 [endoplasmic reticulum membrane]
(Sus scrofa)
CYP7B1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
1355
ENSEMBL
ENST00000310193
,
ENSP00000310721
,
ENSG00000172817
OpenTargets
ENSG00000172817
IntEnz
1.14.14.29
GeneCards
CYP7B1
HPA
ENSG00000172817-CYP7B1
PRO
O75881
Pharos - Targets
O75881
Orphanet
CYP7B1
HMDB Protein
HMDBP01629
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.564
2
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