Reactome | Me2-R108,R112-SNRPB [nucleoplasm]

Me2-R108,R112-SNRPB [nucleoplasm]

Stable Identifier

R-HSA-192213

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

dimethylated Sm Protein B, Small nuclear ribonucleoprotein associated proteins B and B', snRNP-B, Sm protein B/B', Sm-B/Sm-B', SmB/SmB'

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
11720283	Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein de Brabandere, V, Meheus, L, Brahms, H, Luhrmann, R, Fischer, U	RNA	2001

External Reference Information

External Reference

UniProt:P14678 SNRPB

Gene Names

SNRPB, COD, SNRPB1

Chain

chain:1-240

Reference Genes

COSMIC (genes):SNRPB SNRPB

dbSNP Gene:6628 SNRPB

ENSEMBL:ENSG00000125835 SNRPB

Participates

as a member of

Me2-R108,R112-SNRPB,SNRPN [nucleoplasm] (Homo sapiens)

as a component of

snRNP Sm core complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

2xMe-SNRPB [cytosol]

SNRPB [cytosol]

SNRPB [nucleoplasm]

Inferred To

Me2-R108,R112-SNRPB [nucleoplasm] (Plasmodium falciparum)

smb1 [nucleoplasm] (Schizosaccharomyces pombe)

SNRPN [nucleoplasm] (Bos taurus)

SNRPN [nucleoplasm] (Sus scrofa)

SMB1 [nucleoplasm] (Saccharomyces cerevisiae)

SNRPB [nucleoplasm] (Bos taurus)

SNRPB [nucleoplasm] (Canis familiaris)

SNRPB [nucleoplasm] (Gallus gallus)

Homologues of Me2-R108,R112-SNRPB [nucleoplasm] (Bos taurus)

Snrpb [nucleoplasm] (Mus musculus)

Snrpb [nucleoplasm] (Rattus norvegicus)

snr-2 [nucleoplasm] (Caenorhabditis elegans)

SmB [nucleoplasm] (Drosophila melanogaster)

snrpb [nucleoplasm] (Danio rerio)

snrpb [nucleoplasm] (Dictyostelium discoideum)

snrpb [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

symmetric dimethyl-L-arginine at 108

Coordinate

108

PsiMod Name

symmetric dimethyl-L-arginine

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.

Name

symmetric dimethyl-L-arginine at 112

Coordinate

112

PsiMod Name

symmetric dimethyl-L-arginine

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.

Interactors (77)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95400 CD2BP2	1	CD2BP2 [nucleoplasm] (R-HSA-72054)	0.882	11
UniProt:P62318 SNRPD3	3	2xMe-SNRPD3 [cytosol] (R-HSA-191781) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219) SNRPD3 [nucleoplasm] (R-HSA-71903)	0.88	8
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.801	6
UniProt:P57678 GEMIN4	2	GEMIN4 [nucleoplasm] (R-HSA-191841) GEMIN4 [cytosol] (R-HSA-191836)	0.8	5
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [cytosol] (R-HSA-192217) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215)	0.793	5
UniProt:P62316 SNRPD2	2	SNRPD2 [cytosol] (R-HSA-191810) SNRPD2 [nucleoplasm] (R-HSA-71901)	0.793	7
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.793	7
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.793	7
UniProt:P08621 SNRNP70	1	SNRNP70 [nucleoplasm] (R-HSA-71913)	0.784	8
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.768	7
UniProt:P62308 SNRPG	2	SNRPG [cytosol] (R-HSA-191827) SNRPG [nucleoplasm] (R-HSA-71909)	0.734	5
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.725	5
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.723	6
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.669	4
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.669	3
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.669	4
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.669	3
UniProt:O75643 SNRNP200	1	SNRNP200 [nucleoplasm] (R-HSA-71885)	0.669	4
UniProt:O43719 HTATSF1	1	HTATSF1 [nucleoplasm] (R-HSA-9770246)	0.669	4
UniProt:Q15020 SART3			0.669	4
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.648	4
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [cytosol] (R-HSA-191833) GEMIN5 [nucleoplasm] (R-HSA-191765)	0.643	4
UniProt:Q9Y3F4 STRAP	1	STRAP [cytosol] (R-HSA-2127556)	0.59	2
UniProt:P38432 COIL			0.564	2
UniProt:P54253 ATX1			0.556	3
UniProt:Q9Y333 LSM2	2	LSM2 [nucleoplasm] (R-HSA-71894) LSM2 [cytosol] (R-HSA-429849)	0.547	2
UniProt:O95777 LSM8	1	LSM8 [nucleoplasm] (R-HSA-6806779)	0.547	2
UniProt:Q96LT9 RNPC3	1	RNPC3 [nucleoplasm] (R-HSA-6787844)	0.527	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2
UniProt:O14893 GEMIN2	2	GEMIN2 [nucleoplasm] (R-HSA-191795) GEMIN2 [cytosol] (R-HSA-191835)	0.527	2
UniProt:P08579 SNRPB2	1	SNRPB2 [nucleoplasm] (R-HSA-71960)	0.527	5
UniProt:Q9BWJ5 SF3B5	1	SF3B5 [nucleoplasm] (R-HSA-71979)	0.527	2
UniProt:O43172 PRPF4	1	PRPF4 [nucleoplasm] (R-HSA-71890)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	4
UniProt:O60508 CDC40	1	CDC40 [nucleoplasm] (R-HSA-72062)	0.527	2
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.527	2
UniProt:Q96DI7 SNRNP40	1	SNRNP40 [nucleoplasm] (R-HSA-71877)	0.527	3
UniProt:Q9UHI6 DDX20	2	DDX20 [nucleoplasm] (R-HSA-191847) DDX20 [cytosol] (R-HSA-191838)	0.527	2
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.527	2
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.527	3
UniProt:Q6IEG0 SNRNP48	1	SNRNP48 [nucleoplasm] (R-HSA-6787849)	0.527	2
UniProt:Q9BWU0 NADAP			0.527	3
UniProt:Q86VM9 ZCH18			0.527	2
UniProt:Q8WXD5 GEMIN6	2	GEMIN6 [nucleoplasm] (R-HSA-191799) GEMIN6 [cytosol] (R-HSA-191771)	0.527	2
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.527	2
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.527	2
UniProt:Q9BZJ0 CRNKL1	1	CRNKL1 [nucleoplasm] (R-HSA-8867899)	0.527	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.527	3
UniProt:Q6P2Q9 PRPF8	1	PRPF8 [nucleoplasm] (R-HSA-83810)	0.527	3
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	3
UniProt:Q8N954 GPT11			0.527	2
UniProt:Q8IYT2 CMTR2			0.527	3
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.527	3
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.527	4
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.527	2
UniProt:P62312 LSM6	2	LSM6 [nucleoplasm] (R-HSA-6806794) LSM6 [cytosol] (R-HSA-429936)	0.527	2
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	4
UniProt:Q9Y5B6 PAXB1			0.527	2
UniProt:P83876 TXNL4A	1	TXNL4A [nucleoplasm] (R-HSA-71875)	0.527	2
UniProt:Q96GM8 TOE1			0.527	3
UniProt:Q9NWZ8 GEMIN8	2	GEMIN8 [nucleoplasm] (R-HSA-8932892) GEMIN8 [cytosol] (R-HSA-8932878)	0.527	3
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:Q56P03 EAPP			0.527	3
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.527	3
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	4
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.527	2
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.527	3
UniProt:P52298 NCBP2	2	NCBP2 [cytosol] (R-HSA-162458) NCBP2 [nucleoplasm] (R-HSA-51463)	0.527	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.527	2
UniProt:Q13523 PRPF4B	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.527	2
UniProt:Q96RS0 TGS1	2	TGS1 [cytosol] (R-HSA-192209) TGS1 [nucleoplasm] (R-HSA-400176)	0.527	2
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.527	2
UniProt:Q12874 SF3A3	1	SF3A3 [nucleoplasm] (R-HSA-71966)	0.527	2
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.527	3
UniProt:Q9Y312 AAR2			0.527	2
UniProt:Q9UK45 LSM7	2	LSM7 [cytosol] (R-HSA-2028610) LSM7 [nucleoplasm] (R-HSA-6806802)	0.527	2
UniProt:Q9BQA1 WDR77	3	WDR77 [cytosol] (R-HSA-191823) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [nucleoplasm] (R-HSA-5205610)	0.527	3

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