Reactome | IPO5 [nucleoplasm]

IPO5 [nucleoplasm]

Stable Identifier

R-HSA-192675

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Importin beta-3, Ran binding protein-5

Locations in the PathwayBrowser for interactor UniProt:Q96AP0 ACD

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        vRNP Assembly (Homo sapiens)
        
        Viral Polymerase Assembly (Homo sapiens)
        
        IPO5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00410 IPO5

Gene Names

IPO5, KPNB3, RANBP5

Chain

initiator methionine:, chain:2-1097

Reference Genes

BioGPS Gene:3843 IPO5

COSMIC (genes):IPO5 IPO5

CTD Gene:3843 IPO5

dbSNP Gene:3843 IPO5

ENSEMBL:ENSG00000065150 IPO5

HGNC:6402 IPO5

KEGG:hsa:3843 IPO5

Monarch:3843 IPO5

NCBI Gene:3843 IPO5

OMIM:602008 IPO5

UCSC:O00410 IPO5

Reference Transcript

This entity regulates

Positively

Viral Polymerase Assembly (Homo sapiens)

Cross References

OpenTargets

ENSG00000065150

ENSEMBL

ENST00000261574, ENSP00000418393, ENST00000357602, ENSP00000350219, ENST00000490680, ENSG00000065150, ENSP00000261574, ENST00000651721, ENSP00000499125

HPA

ENSG00000065150-IPO5

GeneCards

IPO5

PRO

O00410

Pharos - Targets

O00410

GlyGen

O00410

HMDB Protein

HMDBP08466

PDB

6XTE, 6XU2

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.688	6
UniProt:P18124 RPL7	1	RPL7 [cytosol] (R-HSA-72486)	0.645	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	10
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [cytosol] (R-HSA-5671757) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [autophagosome membrane] (R-HSA-5683637)	0.591	4
UniProt:O95166 GABARAP	3	GABARAP [cytosol] (R-HSA-975521) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [autophagosome membrane] (R-HSA-5683634)	0.591	6
UniProt:P27958-PRO_0000037576			0.581	5
UniProt:P15659 PA			0.547	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.544	2
UniProt:Q9BXW4 MAP1LC3C	3	MAP1LC3C [cytosol] (R-HSA-5679223) MAP1LC3C(1-147) [cytosol] (R-HSA-5682653) MAP1LC3C [autophagosome membrane] (R-HSA-5683638)	0.544	2
UniProt:Q9Y4W2 LAS1L	1	LAS1L [nucleoplasm] (R-HSA-6791521)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q05513 PRKCZ	5	PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.527	2
UniProt:Q9BVI4 NOC4L	1	NOC4L [nucleoplasm] (R-HSA-6790616)	0.527	2
UniProt:P78316 NOP14	1	NOP14 [nucleoplasm] (R-HSA-6790710)	0.527	2
UniProt:Q96GV9 MACIR			0.527	2
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.527	3
UniProt:Q9BYC9 MRPL20	1	MRPL20 [mitochondrial inner membrane] (R-HSA-5368243)	0.527	2
UniProt:Q9Y3C1 NOP16			0.527	2
UniProt:Q8WTT2 NOC3L			0.527	2
UniProt:Q9GZR2 REXO4			0.527	2
UniProt:Q8IXI1 RHOT2	1	RHOT2 [mitochondrial outer membrane] (R-HSA-3006730)	0.527	2
UniProt:Q8IXI2 RHOT1	2	PolyUb-RHOT1 [mitochondrial outer membrane] (R-HSA-6783139) RHOT1 [mitochondrial outer membrane] (R-HSA-3006728)	0.527	2
UniProt:Q9UH62 ARMCX3	1	ARMCX3 [mitochondrial outer membrane] (R-HSA-9714514)	0.527	2
UniProt:Q9UMY1 UTP16			0.527	2
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.508	2
UniProt:Q9BVP2 GNL3	1	GNL3 [nucleoplasm] (R-HSA-8869324)	0.483	3

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