Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HSP90AA1 [cytosol]
Stable Identifier
R-HSA-192864
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
HSP90
Icon
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Aggrephagy (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 dissociate from complex (Homo sapiens)
HSP90:HSF1 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VCP:PolyUb-Misfolded Proteins:HDAC6:HSP90:HSF1 [cytosol] (Homo sapiens)
VCP:HDAC6:HSP90:HSF1 [cytosol] (Homo sapiens)
HSP90:HSF1 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 (Homo sapiens)
VCP:HDAC6:HSP90:HSF1 [cytosol] (Homo sapiens)
HSP90:HSF1 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VCP:PolyUb-Misfolded Proteins:HDAC6:HSP90:HSF1 [cytosol] (Homo sapiens)
VCP:HDAC6:HSP90:HSF1 [cytosol] (Homo sapiens)
HSP90:HSF1 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
Association of NuMA with microtubules (Homo sapiens)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Translocation of NuMA to the centrosomes (Homo sapiens)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
AURKA Activation by TPX2 (Homo sapiens)
TPX2 binds AURKA at centrosomes (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
TPX2 promotes AURKA autophosphorylation (Homo sapiens)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Centrosome maturation (Homo sapiens)
Loss of proteins required for interphase microtubule organization from the centrosome (Homo sapiens)
Loss of C-Nap-1 from centrosomes (Homo sapiens)
cNAP-1 depleted centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Loss of Nlp from mitotic centrosomes (Homo sapiens)
Dissociation of Phospho-Nlp from the centrosome (Homo sapiens)
Nlp-depleted centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Plk1-mediated phosphorylation of Nlp (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
Recruitment of CDK11p58 to the centrosomes (Homo sapiens)
Centrosomes containing recruited CDK11p58 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Recruitment of Plk1 to centrosomes (Homo sapiens)
Centrosome associated Plk1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
AJUBA binds centrosome-associated AURKA (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Centrosome:AURKA:AJUBA [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
AJUBA facilitates AURKA autophosphorylation (Homo sapiens)
Centrosome:AURKA:AJUBA [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
AURKA phosphorylates PLK1 (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
BORA binds PLK1 and AURKA (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
The role of GTSE1 in G2/M progression after G2 checkpoint (Homo sapiens)
GTSE1 binds CDKN1A (Homo sapiens)
GTSE1:CDKN1A:FKBPL:HSP90 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
HSF1 activation (Homo sapiens)
Dissociation of cytosolic HSF1:HSP90 complex (Homo sapiens)
HSF1:HSP90:PTGES3 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Homo sapiens)
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
AR binds AR agonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR:AR agonists [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
AR binds AR antagonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR:AR antagonists [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ATP binding to HSP90 triggers conformation change (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90 dimer:ATP:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Androgens binds AR (in the HSP90 chaperone complex) (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90 dimer:ATP:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90 dimer:ATP:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol] (Homo sapiens)
HSP90 dimer:ATP:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP5:PTGES3:nascent protein: [cytosol] (Homo sapiens)
HSP90 dimer:ATP:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90 dimer:ATP:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90 dimer:ATP:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
NR3C1 binds NR3C1 agonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
NR3C2 binds NR3C2 antagonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
NR3C2:NR3C2 antagonists [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
NR3C2 binds fludrocortisone (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
NR3C2:fludrocortisone [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
P4 bind PGR (in the HSP90 chaperone complex) (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
PGR binds PGR agonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
PGR:PGR agonists [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
PGR binds PGR antagonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
PGR:PGR antagonists [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol] (Homo sapiens)
HSP90 dimer:ATP:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90 dimer:ATP:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Homo sapiens)
HSP90:ATP:FKBP5:PTGES3:nascent protein: [cytosol] (Homo sapiens)
HSP90 dimer:ATP:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90 dimer:ATP:nascent protein [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema3A PAK dependent Axon repulsion (Homo sapiens)
Dimerization of LIMK1 by Hsp90 (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
pLIMK dimer:HSP-90 [cytosol] (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Transphosphorylation of pLIMK1 (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
pLIMK dimer:HSP-90 [cytosol] (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGFRvIII cancer variant does not bind EGF ligand (Homo sapiens)
EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGFRvIII does not bind CBL (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. (Homo sapiens)
EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90 is inactivated by binding to benzaquinoid ansamycins (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:Benzoquinoid ansamycins [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-independent dimerization of EGFRvIII mutant (Homo sapiens)
EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Phosphorylation of SHC1 by p-5Y-EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII:SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)
p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Trans-autophosphorylation of EGFRvIII mutant dimers (Homo sapiens)
EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Binding of EGF to ligand-responsive EGFR mutants (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors (Homo sapiens)
Resistant ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs [plasma membrane] (Homo sapiens)
Resistant ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF-induced dimerization of ligand-responsive EGFR mutants (Homo sapiens)
EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90 is inactivated by binding to benzaquinoid ansamycins (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:Benzoquinoid ansamycins [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants (Homo sapiens)
Active dimers of ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Resistant ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Sensitive ligand-responsive EGFR mutants:Non-covalent EGFR TKIs [plasma membrane] (Homo sapiens)
Active dimers of ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)
Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Spontaneous dimerization of ligand-responsive EGFR mutants (Homo sapiens)
Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)
Active dimers of ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
ERBB2 binds TKIs (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 binds trastuzumab (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 homodimerization (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Drug resistance in ERBB2 KD mutants (Homo sapiens)
Resistance of ERBB2 KD mutants to AEE788 (Homo sapiens)
Resistant ERBB2 KD mutants do not bind AEE788 (Homo sapiens)
ERBB2 KD mutants (AEE788 resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to afatinib (Homo sapiens)
ERBB2 T798M does not bind afatinib (Homo sapiens)
ERBB2 T798M:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to lapatinib (Homo sapiens)
Resistant ERBB2 KD mutants do not bind lapatinib (Homo sapiens)
ERBB2 KD mutants (lapatinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to neratinib (Homo sapiens)
Resistant ERBB2 KD mutants do not bind neratinib (Homo sapiens)
ERBB2 KD mutants (neratinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to osimertinib (Homo sapiens)
ERBB2 KD mutants do not bind osimertinib (Homo sapiens)
ERBB2 KD mutants (osimertinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to sapitinib (Homo sapiens)
ERBB2 T862A does not bind sapitinib (Homo sapiens)
ERBB2 T862A:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to tesevatinib (Homo sapiens)
ERBB2 T733I does not bind tesevatinib (Homo sapiens)
ERBB2 T733I:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Resistance of ERBB2 KD mutants to trastuzumab (Homo sapiens)
Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)
ERBB2 KD mutants (trastuzumab resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Drug resistance in ERBB2 TMD/JMD mutants (Homo sapiens)
ERBB2 TMD/JMD mutants do not bind pertuzumab (Homo sapiens)
ERBB2 TMD/JMD mutants (pertuzumab resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Signaling by ERBB2 ECD mutants (Homo sapiens)
ERBB2 ECD mutants bind TKIs (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 ECD mutants bind trastuzumab (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Signaling by ERBB2 KD Mutants (Homo sapiens)
ERBB2 KD mutants bind TKIs (Homo sapiens)
ERBB2 KD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 KD mutants bind trastuzumab (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 KD mutants heterodimerize (Homo sapiens)
ERBB2 KD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
ERBB2 TMD/JMD mutants bind TKIs (Homo sapiens)
ERBB2 TMD/JMD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 TMD/JMD mutants (TKI sensitive):TKI:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 TMD/JMD mutants bind pertuzumab (Homo sapiens)
ERBB2 R678Q:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 R678Q:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 TMD/JMD mutants bind trastuzumab (Homo sapiens)
ERBB2 TMD/JMD mutants (trastuzumab):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 TMD/JMD mutants (trastuzumab):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)
ERBB2 TMD/JMD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of diphtheria toxin (Homo sapiens)
DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Influenza Viral RNA Transcription and Replication (Homo sapiens)
vRNP Assembly (Homo sapiens)
Viral Polymerase Assembly (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
Assembly and release of respiratory syncytial virus (RSV) virions (Homo sapiens)
Budding of hRSV A virions from infected cell (Homo sapiens)
HSP90 dimer [cytosol] (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
Respiratory syncytial virus genome replication (Homo sapiens)
Synthesis of antigenomic RNA of human respiratory syncytial virus (Homo sapiens)
HSP90 dimer [cytosol] (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
NR3C1 binds NR3C1 agonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)
HSP90:TBK1:IRF3 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
MAVS:TOMM70:HSP90:TBK1:IRF3 [mitochondrial outer membrane] (Homo sapiens)
HSP90:TBK1:IRF3 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
PIWI-interacting RNA (piRNA) biogenesis (Homo sapiens)
Complexed PIWIL4 binds cleaved transposon RNA (Homo sapiens)
FKBP6:HSP90AA1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated cytosolic proteins (Homo sapiens)
STAT3-upregulated cytosolic proteins [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
HSP90 binds TBK1 and IRF3 (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90:TBK1:IRF3 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)
HSP90:TBK1:IRF3 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
MAVS:TOMM70:HSP90:TBK1:IRF3 [mitochondrial outer membrane] (Homo sapiens)
HSP90:TBK1:IRF3 [cytosol] (Homo sapiens)
HSP90:HSP90 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Dimerization of LIMK1 by Hsp90 (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
pLIMK dimer:HSP-90 [cytosol] (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Transphosphorylation of pLIMK1 (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
pLIMK dimer:HSP-90 [cytosol] (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
AKT1 phosphorylates eNOS (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Uncoupled eNOS favours the formation of superoxide (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Anchoring of the basal body to the plasma membrane (Homo sapiens)
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
C2CD3 binds the mother centriole (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
CP110 and CEP97 dissociate from the centriole (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
MARK4 binds ODF2 in the centriole (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Recruitment of transition zone proteins (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
The distal appendage proteins recruit TTBK2 (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
MLKL binds HSP90:CDC37 (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
MLKL:HSP90:CDC37 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
RIPK3 binds HSP90:CDC37 (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
RIPK3:HSP90:CDC37 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
CUL5 mediates ubiquitination of ERBB2 (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Drug-mediated inhibition of ERBB2 signaling (Homo sapiens)
ERBB2 binds TKIs (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 binds pertuzumab (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 binds trastuzumab (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
BCAR1 binds p-7Y-PTK2 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1:BCAR1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
CRK binds BCAR1 and or PXN (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
DOCK180:ELMO binds CRK (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
PTK2/SRC-1 phosphorylates BCAR1 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1:BCAR1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
PXN binds p-6Y,S732-PTK2 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
AKT1 phosphorylates eNOS (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOBTB GTPase Cycle (Homo sapiens)
RHOBTB2 GTPase cycle (Homo sapiens)
RHOBTB2 binds GTP (Homo sapiens)
HSP90:CDC37 [cytosol] (Homo sapiens)
HSP90 dimer [cytosol] (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07900 HSP90AA1
Gene Names
HSP90AA1, HSP90A, HSPC1, HSPCA
Chain
initiator methionine:, chain:2-732
Reference Genes
BioGPS Gene:3320 HSP90AA1
COSMIC (genes):HSP90AA1 HSP90AA1
CTD Gene:3320 HSP90AA1
dbSNP Gene:3320 HSP90AA1
ENSEMBL:ENSG00000080824 HSP90AA1
ENSEMBL_homo_sapiens_GENE:ENSG00000080824.19 HSP90AA1
HGNC:5253 HSP90AA1
KEGG Gene (Homo sapiens):3320 HSP90AA1
Monarch:3320 HSP90AA1
NCBI Gene:3320 HSP90AA1
OMIM:140571 HSP90AA1
UCSC:P07900 HSP90AA1
Reference Transcript
RefSeq:NM_001017963.2 HSP90AA1
RefSeq:NM_005348.3 HSP90AA1
Other Identifiers
11732996_at
11749934_s_at
11758308_s_at
16796829
210211_PM_s_at
210211_s_at
211968_PM_s_at
211968_s_at
211969_PM_at
211969_at
214328_PM_s_at
214328_s_at
2362304
2545387
2751645
2755868
2755880
2793561
2793563
2793567
32316_s_at
3320
3367313
3367314
3367315
3367316
3367317
3367319
3367320
3367322
3367324
3367325
3367327
3367328
3367329
3580178
3580180
3580181
3580182
3580184
3580185
3580187
3580188
3580190
3580192
3580194
3580196
3580197
3580198
3580200
3580203
3580204
3580207
3580208
3580210
3580211
3580219
3580230
7981335
A_23_P162866
A_23_P162874
A_33_P3665777
GE59722
GO:0000166
GO:0001764
GO:0001934
GO:0002134
GO:0002135
GO:0002218
GO:0002230
GO:0002376
GO:0003009
GO:0003012
GO:0003013
GO:0003723
GO:0003729
GO:0003824
GO:0005515
GO:0005524
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005773
GO:0005829
GO:0005886
GO:0005929
GO:0006457
GO:0006839
GO:0006886
GO:0006913
GO:0006914
GO:0006986
GO:0007004
GO:0007005
GO:0008092
GO:0009408
GO:0009409
GO:0009410
GO:0009651
GO:0009986
GO:0010592
GO:0010659
GO:0012501
GO:0016020
GO:0016323
GO:0016324
GO:0016787
GO:0016887
GO:0017098
GO:0019903
GO:0023026
GO:0030154
GO:0030163
GO:0030235
GO:0030312
GO:0030911
GO:0031012
GO:0031396
GO:0031410
GO:0031526
GO:0031625
GO:0032200
GO:0032273
GO:0032564
GO:0032728
GO:0032880
GO:0032991
GO:0034605
GO:0034774
GO:0036126
GO:0036211
GO:0042026
GO:0042220
GO:0042307
GO:0042470
GO:0042802
GO:0042803
GO:0042826
GO:0042981
GO:0043025
GO:0043202
GO:0043209
GO:0043226
GO:0043254
GO:0043335
GO:0043627
GO:0044183
GO:0044294
GO:0044295
GO:0044325
GO:0045040
GO:0045429
GO:0045732
GO:0045793
GO:0046677
GO:0048156
GO:0048471
GO:0048856
GO:0048870
GO:0050821
GO:0050877
GO:0051020
GO:0051022
GO:0051082
GO:0051131
GO:0051973
GO:0060452
GO:0061024
GO:0061684
GO:0062023
GO:0065003
GO:0070062
GO:0070182
GO:0071682
GO:0097110
GO:0097226
GO:0097524
GO:0097718
GO:0098542
GO:0098586
GO:0098772
GO:0099072
GO:0140657
GO:0140662
GO:1902949
GO:1904813
GO:1905323
GO:1990782
HMNXSV003006689
Hs.289088.4.A1_3p_at
Hs.289088.4.A2_3p_a_at
ILMN_1691097
ILMN_2373515
PH_hs_0033549
TC14001526.hg
TC14002169.hg
X15183_at
g3287488_3p_a_at
Participates
as a component of
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
FKBP6:HSP90AA1 [cytosol] (Homo sapiens)
cNAP-1 depleted centrosome [cytosol] (Homo sapiens)
Nlp-depleted centrosome [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
as a member of
STAT3-upregulated cytosolic proteins [cytosol] (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
as an input of
HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
This entity regulates
Positively
DT fragment B transports DT fragment A from target cell endosome membrane
(Homo sapiens)
Viral Polymerase Assembly
(Homo sapiens)
Other forms of this molecule
HSP90AA1 [secretory granule lumen]
HSP90AA1 [ficolin-1-rich granule lumen]
HSP90AA1 [endocytic vesicle lumen]
HSP90AA1 [extracellular region]
HSP90AA1 [plasma membrane]
HSP90AA1 [nucleoplasm]
HSP90AA1 [lysosomal lumen]
Inferred To
Homologues of HSP90AA1 [cytosol]
(Plasmodium falciparum)
Homologues of HSP90AA1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of HSP90AA1 [cytosol]
(Sus scrofa)
hsp90aa1.1 [cytosol]
(Xenopus tropicalis)
hsp90aa1.2 [cytosol]
(Danio rerio)
HSP90AA1 [cytosol]
(Bos taurus)
HSP90AA1 [cytosol]
(Caenorhabditis elegans)
HSP90AA1 [cytosol]
(Canis familiaris)
HSP90AA1 [cytosol]
(Dictyostelium discoideum)
HSP90AA1 [cytosol]
(Drosophila melanogaster)
HSP90AA1 [cytosol]
(Gallus gallus)
HSP90AA1 [cytosol]
(Mus musculus)
HSP90AA1 [cytosol]
(Plasmodium falciparum)
HSP90AA1 [cytosol]
(Rattus norvegicus)
HSP90AA1 [cytosol]
(Saccharomyces cerevisiae)
HSP90AA1 [cytosol]
(Schizosaccharomyces pombe)
HSP90AA1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_005339.3
,
NP_001017963.2
Guide to Pharmacology - Targets
2905
OpenTargets
ENSG00000080824
ZINC - Substances
HS90A_HUMAN
ZINC - Biogenic
HS90A_HUMAN
ZINC target
P07900
PRO
P07900
PDB
5J20
,
5LO5
,
3Q6N
,
4CWO
,
5J86
,
5XRE
,
2WI6
,
6EYB
,
6U9A
,
7S95
,
3BMY
,
6CYG
,