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Androgen biosynthesis
Stable Identifier
R-HSA-193048
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Metabolism of steroid hormones (Homo sapiens)
Androgen biosynthesis (Homo sapiens)
General
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Androgens are the determining factors for male development and behaviour in vertebrates (Miller 2002).
Literature References
PubMed ID
Title
Journal
Year
12428201
Disorders of androgen biosynthesis
Miller, WL
Semin Reprod Med
2002
Participants
Events
CYP17A1 17-hydroxylates PREG
(Homo sapiens)
CYP17A1 cleaves 17aHPREG to DHA
(Homo sapiens)
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST
(Homo sapiens)
CYP17A1 17-hydroxylates P4 to 17aHPROG
(Homo sapiens)
CYP17A1 cleaves 17aHPROG to ANDST
(Homo sapiens)
HSD17B3-like proteins reducde ANDST to TEST
(Homo sapiens)
SRD5A1 dehydrogenates TEST to DHTEST
(Homo sapiens)
SRD5A2 dehydrogenates TEST to DHTEST
(Homo sapiens)
SRD5A2 binds SRD5A2 inhibitors
(Homo sapiens)
SRD5A3 dehydrogenates TEST to DHTEST
(Homo sapiens)
Participates
as an event of
Metabolism of steroid hormones (Homo sapiens)
Event Information
Go Biological Process
androgen biosynthetic process (0006702)
Orthologous Events
Androgen biosynthesis (Bos taurus)
Androgen biosynthesis (Caenorhabditis elegans)
Androgen biosynthesis (Canis familiaris)
Androgen biosynthesis (Danio rerio)
Androgen biosynthesis (Dictyostelium discoideum)
Androgen biosynthesis (Drosophila melanogaster)
Androgen biosynthesis (Gallus gallus)
Androgen biosynthesis (Mus musculus)
Androgen biosynthesis (Plasmodium falciparum)
Androgen biosynthesis (Rattus norvegicus)
Androgen biosynthesis (Saccharomyces cerevisiae)
Androgen biosynthesis (Schizosaccharomyces pombe)
Androgen biosynthesis (Sus scrofa)
Androgen biosynthesis (Xenopus tropicalis)
Authored
Jassal, B (2008-10-01)
Reviewed
D'Eustachio, P (2007-04-21)
Created
Jassal, B (2007-02-13)
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