Reactome | Pregn-5-ene-3,20-dione isomerizes to progesterone

Pregn-5-ene-3,20-dione isomerizes to progesterone

Stable Identifier

R-HSA-193052

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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Pregn-5-ene-3,20-dione isomerizes to progesterone. This reaction is catalyzed by the isomerase activity of 3 beta-HSD, associated with the endoplasmic reticulum membrane. The active form of the enzyme is a homodimer. The enzyme occurs in two isoforms that are similar in their biochemical properties but differ in their tissue expression: type I (HSD3B1) is found in placenta and skin, while type II (HSD3B2) is found in the adrenal glands and gonads.
The hormone lutropin (LH) triggers ovulation and development of the corpus luteum, that in turn increases production of progesterone.

Literature References

PubMed ID	Title	Journal	Year
2770297	Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes Strickler, RC, Myers, RP, Thomas, JL	J Steroid Biochem	1989
1944309	Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads Simard, J, Rheaume, E, de Launoit, Y, Lachance, Y, Breton, N, Luu-The, V, Labrie, F, Trudel, C, Dumont, M, Zhao, HF	Mol Endocrinol	1991
12832414	Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase Duax, WL, Brandt, S, Norris, W, Addlagatta, A, Fuller, RR, Thomas, JL	J Biol Chem	2003
2243100	Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells Simard, J, de Launoit, Y, Lachance, Y, Luu-The, V, Labrie, F, Leblanc, G, Dumont, M, Labrie, C, Guerin, S	J Biol Chem	1990