Reactome | HSD17B3-like proteins reducde ANDST to TEST

HSD17B3-like proteins reducde ANDST to TEST

Stable Identifier

R-HSA-193064

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

Reduction of androstenedione to testosterone

ReviewStatus

5/5

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HSD17B3-like proteins reducde ANDST to TEST

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The 17HSD family of enzymes catalyze the final step in the synthesis of estradiol and testosterone. They convert inactive 17-ketosteroids to their active 17beta-hydroxy forms. Androstenedione, a ketosteroid, is reduced to testosterone, a highly potent androgen, by the enzyme 17beta-hydroxysteroid dehydrogenase isoform III (17HSD3). The other human isoforms of 17HSDs to take part in the final steps of active steroid biosynthesis are types 1 and VII, which reduce estrone to estradiol.
Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).
In males, Lutropin (LH) stimulates testosterone production. In females, lutropin (LH) can trigger ovulation.

Literature References

PubMed ID	Title	Journal	Year
8547185	Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition Poirier, D, Luu-The, V, Labrie, F, Zhang, Y	J Steroid Biochem Mol Biol	1995
9536209	A critical review of the origin and control of adrenal androgens Fearon, U, Clarke, D, McKenna, TJ, Cunningham, SK	Baillieres Clin Obstet Gynaecol	1997
2197970	Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase Simard, J, Lagace, L, Lachance, Y, Cote, J, Luu-The, V, Labrie, F, Gagne, R, Berube, D, Leblanc, G, Labrie, C, Couet, J, Zhao, HF	Ann N Y Acad Sci	1990
8075637	Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3 Bradshaw, KD, Andersson, S, Geissler, WM, Russell, DW, Wilson, JD, Patel, S, Davis, DL, Mendonca, BB, Wu, L, Elliston, KO	Nat Genet	1994