HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST

Stable Identifier
R-HSA-193073
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
DHA isomerizes to 4-Androstene3,17-dione
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In this two-step reaction catalyzed by 3beta-HSD associated with the endoplasmic reticulum membrane, the 3-hydroxyl group of DHA is oxidized to a keto group and the double bond in the steroid nucleus is then isomerized from the five to the 4 position. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).

Literature References
PubMed ID Title Journal Year
2243100 Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells

Lachance, Y, Luu-The, V, Labrie, C, Simard, J, Dumont, M, de Launoit, Y, Guerin, S, Leblanc, G, Labrie, F

J Biol Chem 1990
9536209 A critical review of the origin and control of adrenal androgens

McKenna, TJ, Fearon, U, Clarke, D, Cunningham, SK

Baillieres Clin Obstet Gynaecol 1997
Participants
Participates
Catalyst Activity

steroid delta-isomerase activity of HSD2B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]

This event is regulated
Positively by
Regulator
Summation

Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).

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