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Estrogen biosynthesis
Stable Identifier
R-HSA-193144
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Metabolism of steroid hormones (Homo sapiens)
Estrogen biosynthesis (Homo sapiens)
General
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In female vertebrates, estrogens control reproductive system development and reproductive functions (Payne AH and Hales DB, 2004).
Literature References
PubMed ID
Title
Journal
Year
15583024
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones
Payne, AH
,
Hales, DB
Endocr Rev
2004
Participants
Events
CYP19A1 hydroxylates TEST to EST17b
(Homo sapiens)
CYP19A1 hydroxylates ANDST to E1
(Homo sapiens)
CYP19A1 binds Aromatase inhibitors
(Homo sapiens)
HSD17B1 hydrogenates E1 to EST17b
(Homo sapiens)
HSD17B11 dehydrogenates EST17b to E1
(Homo sapiens)
AKR1B15 reduces EST17b to E1
(Homo sapiens)
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)
(Homo sapiens)
HSD17B2 oxidises estradiol (E2) to estrone (E1)
(Homo sapiens)
Participates
as an event of
Metabolism of steroid hormones (Homo sapiens)
Event Information
Go Biological Process
estrogen biosynthetic process (0006703)
Orthologous Events
Estrogen biosynthesis (Bos taurus)
Estrogen biosynthesis (Caenorhabditis elegans)
Estrogen biosynthesis (Canis familiaris)
Estrogen biosynthesis (Danio rerio)
Estrogen biosynthesis (Dictyostelium discoideum)
Estrogen biosynthesis (Drosophila melanogaster)
Estrogen biosynthesis (Gallus gallus)
Estrogen biosynthesis (Mus musculus)
Estrogen biosynthesis (Rattus norvegicus)
Estrogen biosynthesis (Saccharomyces cerevisiae)
Estrogen biosynthesis (Schizosaccharomyces pombe)
Estrogen biosynthesis (Sus scrofa)
Estrogen biosynthesis (Xenopus tropicalis)
Authored
Jassal, B (2008-10-01)
Reviewed
D'Eustachio, P (2007-04-21)
Created
Jassal, B (2007-02-13)
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