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HSD3B7 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-193441
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
3 beta-hydroxysteroid dehydrogenase type 7, 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Homo sapiens)
HSD3B7 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Homo sapiens)
HSD3B7 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Homo sapiens)
HSD3B7 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H2F3 HSD3B7
Gene Names
HSD3B7
Chain
chain:1-369
Reference Genes
BioGPS Gene:80270 HSD3B7
COSMIC (genes):HSD3B7 HSD3B7
CTD Gene:80270 HSD3B7
dbSNP Gene:80270 HSD3B7
ENSEMBL:ENSG00000099377 HSD3B7
HGNC:18324 HSD3B7
Monarch:80270 HSD3B7
NCBI Gene:80270 HSD3B7
OMIM:607764 HSD3B7
UCSC:Q9H2F3 HSD3B7
Reference Transcript
RefSeq:XM_011545962.2 HSD3B7
RefSeq:XM_017023732.1 HSD3B7
RefSeq:NM_025193.3 HSD3B7
RefSeq:NM_001142777.1 HSD3B7
RefSeq:XM_011545961.1 HSD3B7
RefSeq:XM_011545960.2 HSD3B7
RefSeq:XM_005255601.3 HSD3B7
RefSeq:NM_001142778.1 HSD3B7
Other Identifiers
11734172_a_at
11741502_a_at
11752889_x_at
11758252_s_at
16818114
222817_PM_at
222817_at
3656736
3656738
3656739
3656740
3656741
3656742
3656744
3656745
3656746
3656748
3656749
3656750
3656751
3656752
3656753
3656754
3656755
44069_at
7995007
80270
A_14_P100587
A_23_P206819
A_33_P3251776
GE61026
GO:0002376
GO:0003824
GO:0003854
GO:0005515
GO:0005783
GO:0005789
GO:0005811
GO:0006629
GO:0006694
GO:0006699
GO:0008202
GO:0016020
GO:0016491
GO:0016616
GO:0035754
GO:0043226
GO:0047016
GO:0048870
HMNXSV003032373
ILMN_1653042
PH_hs_0002078
TC16000365.hg
g13436259_3p_at
Inferred To
hsd3b7 [endoplasmic reticulum membrane]
(Danio rerio)
hsd3b7 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
HSD3B7 [endoplasmic reticulum membrane]
(Bos taurus)
HSD3B7 [endoplasmic reticulum membrane]
(Canis familiaris)
HSD3B7 [endoplasmic reticulum membrane]
(Mus musculus)
HSD3B7 [endoplasmic reticulum membrane]
(Rattus norvegicus)
HSD3B7 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000099377
ENSEMBL
ENSP00000297679
,
ENSP00000262520
,
ENST00000262520
,
ENST00000297679
IntEnz
1.1.1.181
HPA
ENSG00000099377-HSD3B7
PRO
Q9H2F3
Pharos - Targets
Q9H2F3
Orphanet
HSD3B7
HMDB Protein
HMDBP04980
Interactors (55)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.718
8
UniProt:P10745 RBP3
1
RBP3 [extracellular region]
(R-HSA-2984190)
0.556
3
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.556
3
UniProt:Q5T749 KPRP
1
KPRP [cytosol]
(R-HSA-9839614)
0.556
3
UniProt:Q12805 EFEMP1
1
EFEMP1 [extracellular region]
(R-HSA-2161393)
0.556
3
UniProt:Q8IWZ5 TRI42
0.556
5
UniProt:Q9BYR5 KRTAP4-2
1
KRTAP4-2 [cytosol]
(R-HSA-6809948)
0.556
3
UniProt:P98095 FBLN2
1
FBLN2 [extracellular region]
(R-HSA-2161298)
0.556
3
UniProt:A8MW99 MEI4
0.556
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
3
UniProt:P32243-2 OTX2
0.556
3
UniProt:Q9Y320 TMX2
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:P21964 COMT
2
COMT [cytosol]
(R-HSA-175974)
COMT [plasma membrane]
(R-HSA-379386)
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q8WVV5 BTN2A2
1
BTN2A2 [plasma membrane]
(R-HSA-8851047)
0.556
3
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.556
3
IntAct:EBI-22447855 CCSB ORF ID
0.556
3
UniProt:Q8N720 ZNF655
1
ZNF655 [nucleoplasm]
(R-HSA-2127575)
0.556
3
UniProt:B2RXF5 ZBT42
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.556
3
UniProt:O95994 AGR2
0.556
3
UniProt:Q96GQ5 RUSF1
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:Q3SY46 KRTAP13-3
1
KRTAP13-3 [cytosol]
(R-HSA-6810267)
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
IntAct:EBI-22320186 CCSB ORF ID
0.556
3
IntAct:EBI-10173330 386677
0.556
3
UniProt:Q92624 APBP2
0.556
3
UniProt:O43790 KRT86
1
KRT86 [cytosol]
(R-HSA-6809648)
0.556
3
UniProt:Q9NYG5-2 ANAPC11
0.556
3
UniProt:O43597 SPRY2
8
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
SPRY2 [cytosol]
(R-HSA-182949)
SPRY2 [plasma membrane]
(R-HSA-182924)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
0.556
3
UniProt:Q9UHF1 EGFL7
0.556
3
UniProt:O95967 EFEMP2
1
EFEMP2 [extracellular region]
(R-HSA-2161231)
0.556
3
IntAct:EBI-22384931 CCSB ORF ID
0.556
3
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.556
3
IntAct:EBI-22326698 CCSB ORF ID
0.556
3
UniProt:Q92979 EMG1
1
EMG1 [nucleoplasm]
(R-HSA-6790671)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q5TA78 LCE4A
1
LCE4A [cytosol]
(R-HSA-6814272)
0.556
3
UniProt:Q9GZR5 ELOVL4
1
ELOVL4 [endoplasmic reticulum membrane]
(R-HSA-548705)
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q9H6H4 REEP4
0.556
3
UniProt:Q92570 NR4A3
1
NR4A3 [nucleoplasm]
(R-HSA-8938004)
0.556
3
UniProt:Q9UGC6 RGS17
1
RGS17 [plasma membrane]
(R-HSA-939779)
0.556
3
UniProt:Q02930-3 CREB5
0.556
3
UniProt:Q3LHN2 KRTAP19-2
1
KRTAP19-2 [cytosol]
(R-HSA-6810262)
0.556
3
UniProt:Q96FE5 LINGO1
1
LINGO1 [plasma membrane]
(R-HSA-3006563)
0.556
3
UniProt:Q03989 ARI5A
0.556
3
UniProt:Q6P5X5 CV039
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:Q8WXK4-2 Q8WXK42
0.556
3
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