NGF binding to p75NTR inactivates RHOA

Stable Identifier
R-HSA-193646
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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NGF binding to p75NTR inactivates RHOA
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Neurotrophin (NGF or BDNF) binding to p75NTR increases RHO-GDI activity, possibly by loosening the grip of p75NTR on RHO-GDI, which prevents the dissociation of GDP thus allowing axonal growth to occur (Gehler et al. 2004).
Literature References
PubMed ID Title Journal Year
15128850 p75 neurotrophin receptor signaling regulates growth cone filopodial dynamics through modulating RhoA activity

Letourneau, PC, Gallo, G, Veien, E, Gehler, S

J Neurosci 2004
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Orthologous Events
NGF binding to p75NTR inactivates RHOA (Bos taurus)
NGF binding to p75NTR inactivates RHOA (Canis familiaris)
NGF binding to p75NTR inactivates RHOA (Danio rerio)
NGF binding to p75NTR inactivates RHOA (Gallus gallus)
NGF binding to p75NTR inactivates RHOA (Mus musculus)
NGF binding to p75NTR inactivates RHOA (Rattus norvegicus)
NGF binding to p75NTR inactivates RHOA (Sus scrofa)
NGF binding to p75NTR inactivates RHOA (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-02-23)
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