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NF-kB migrates to the nucleus and turns on transcription
Stable Identifier
R-HSA-193691
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
NF-kB migrates to the nucleus and turns on transcription (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once dissociated from IkB, NF-kB moves to the nucleus. Once in the nucleus, NF-kB binds DNA at promoters of target genes. This entails transcription of several genes including the two HLH transcriptional regulators HES1 and HES5. HES1 and HES5 transcription can also be activated via NOTCH signalling. Increased production of HES1 and HES5 reduces the number of primary dendrites and promotes dendrite elongation.
Literature References
PubMed ID
Title
Journal
Year
15496460
NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch
Arévalo, MA
,
Grantyn, R
,
Rodriguez-Tébar, A
,
Salama-Cohen, P
,
Meier, J
Mol Biol Cell
2005
Participants
Input
NFKB1(1-433):RELA [cytosol]
(Homo sapiens)
Output
NFKB1(1-433):RELA [nucleoplasm]
(Homo sapiens)
Participates
as an event of
NF-kB is activated and signals survival (Homo sapiens)
Orthologous Events
NF-kB migrates to the nucleus and turns on transcription (Bos taurus)
NF-kB migrates to the nucleus and turns on transcription (Canis familiaris)
NF-kB migrates to the nucleus and turns on transcription (Drosophila melanogaster)
NF-kB migrates to the nucleus and turns on transcription (Gallus gallus)
NF-kB migrates to the nucleus and turns on transcription (Mus musculus)
NF-kB migrates to the nucleus and turns on transcription (Sus scrofa)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-02-23)
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