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The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
Stable Identifier
R-HSA-193696
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR regulates axonogenesis (Homo sapiens)
Axonal growth inhibition (RHOA activation) (Homo sapiens)
The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Homo sapiens)
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In the presence of a myelin component (GMDI), such as MAG, NOGO or OMG, bound to a complex of the NOGO receptor (RTN4R, also known as NgR) and NGFR (p75NTR), binding of NGFR to ARHGDIA, a RHO-GDI, associated with RHOA:GDP, is strengthened (Yamashita and Tohyama 2003). The presence of LINGO1 in the complex of NGFR, RTN4R and MAG, NOGO or OMG is needed for NGFR-dependent activation of RHOA (Mi et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
12692556
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
Yamashita, T
,
Tohyama, M
Nat Neurosci
2003
Participants
Input
RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane]
(Homo sapiens)
Output
ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane]
(Homo sapiens)
RHOA:GDP [plasma membrane]
(Homo sapiens)
Participates
as an event of
Axonal growth inhibition (RHOA activation) (Homo sapiens)
Orthologous Events
The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Bos taurus)
The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Canis familiaris)
The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Danio rerio)
The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Mus musculus)
The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Rattus norvegicus)
The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Sus scrofa)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-02-23)
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