p75NTR ICD signals to NF-kB

Stable Identifier
R-HSA-193700
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p75NTR ICD signals to NF-kB
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The p75NTR ICD has the potential to bind many intracellular proteins, including TRAF6, SC1, NADE, NRAGE, and RHOA. It may bring these proteins to function in different cellular compartments. p75NTR ICD was shown to activate NF-kB via TRAF6.
Literature References
PubMed ID Title Journal Year
12843241 Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability

Amieux, PS, Schecterson, LC, Wiley, JC, Hudson, M, Kanning, KC, Bothwell, M

J Neurosci 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
p75NTR ICD signals to NF-kB (Bos taurus)
p75NTR ICD signals to NF-kB (Canis familiaris)
p75NTR ICD signals to NF-kB (Gallus gallus)
p75NTR ICD signals to NF-kB (Mus musculus)
p75NTR ICD signals to NF-kB (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-02-23)
Cite Us!