Part of the ICD migrates to the nucleus

Stable Identifier
R-HSA-193702
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nuclear envelope
ReviewStatus
5/5
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Part of the ICD migrates to the nucleus
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A portion of the p75NTR ICD produced by gamma-secretase cleavage moves to the nucleus where it may participate in transcriptional regulation.
Literature References
PubMed ID Title Journal Year
12843241 Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability

Amieux, PS, Schecterson, LC, Wiley, JC, Hudson, M, Kanning, KC, Bothwell, M

J Neurosci 2003
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Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-02-23)
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