Production of ceramide which can activate JNK and other targets

Stable Identifier
R-HSA-193706
Type
Reaction
Species
Homo sapiens
Compartment
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Sphingomyielinase promotes the conversion of sphingomyelin to ceramide. Ceramide can activate JNK and other targets. The molecular details of the p75NTR-activated ceramide signalling cascade are only partially understood.

Participants
Participates
Catalyst Activity

sphingomyelin phosphodiesterase activity of Active N-SMase:Mg2+ [plasma membrane]

Inferred From
Cross References
Rhea
Authored
Reviewed
Created
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