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SQSTM1 [cytosol]
Stable Identifier
R-HSA-193937
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p62, Sequestosome-1, SQSTM_HUMAN
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Homo sapiens)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
p62 links damaged mitochondria to LC3 (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
Pexophagy (Homo sapiens)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B [peroxisomal membrane] (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B [peroxisomal membrane] (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
HBV X protein binds SQSTM1 oligomer (Homo sapiens)
SQSTM1 oligomer [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 oliogmer:X [cytosol] (Homo sapiens)
SQSTM1 oligomer [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
SQSTM1 oligomer [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 oliogmer:X [cytosol] (Homo sapiens)
SQSTM1 oligomer [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2-dependent SQSTM1 gene expression (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 oligomer is phosphorylated (Homo sapiens)
SQSTM1 oligomer [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 oligomerizes (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 oligomer [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
TRIM21 ubiquitinates SQSTM1 (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
p62:MEKK3 binds to TRAF6 (Homo sapiens)
MAP3K3:SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Homo sapiens)
MAP3K3:SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
SQSTM1 oligomer [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 oliogmer:X [cytosol] (Homo sapiens)
SQSTM1 oligomer [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
Ubiquitinated NRIF:Sequestosome [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
Polyubiquitinated NRIF migrates to the nucleus (Homo sapiens)
Ubiquitinated NRIF:Sequestosome [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
IKKbeta is activated (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
IKK-beta is recruited (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
TRAF6 is auto-ubiquitinated (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
p62 is recruited and forms a complex with TRAF6 (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
p62 recruits an atypical PKC (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13501 SQSTM1
Gene Names
SQSTM1, ORCA, OSIL
Chain
initiator methionine:, chain:2-440, initiator methionine:
Reference Genes
BioGPS Gene:8878 SQSTM1
COSMIC (genes):SQSTM1 SQSTM1
CTD Gene:8878 SQSTM1
dbSNP Gene:8878 SQSTM1
ENSEMBL:ENSG00000161011 SQSTM1
ENSEMBL_homo_sapiens_GENE:ENSG00000161011.20 SQSTM1
ENSEMBL_homo_sapiens_GENE:ENSG00000284099.3 SQSTM1
HGNC:11280 SQSTM1
KEGG Gene (Homo sapiens):8878 SQSTM1
Monarch:8878 SQSTM1
NCBI Gene:8878 SQSTM1
OMIM:601530 SQSTM1
UCSC:Q13501 SQSTM1
Reference Transcript
RefSeq:NM_001142298.1 SQSTM1
RefSeq:XM_017010010.1 SQSTM1
RefSeq:NM_001142299.1 SQSTM1
RefSeq:NM_003900.4 SQSTM1
Other Identifiers
11717290_s_at
11727031_a_at
11745754_x_at
11752843_x_at
11756761_x_at
16993458
201471_PM_s_at
201471_s_at
213112_PM_s_at
213112_s_at
2844499
2844500
2844505
2844506
2844507
2844508
2844509
2844512
2844513
2844514
2844515
2844516
2844518
2844523
2844524
2844528
2844529
2844535
2844536
2844537
2844538
2844539
2844540
2844541
2844542
40898_at
8110569
8878
A_14_P109999
A_23_P81399
GE79794
GO:0000122
GO:0000407
GO:0000422
GO:0000423
GO:0000425
GO:0000932
GO:0001659
GO:0001934
GO:0002376
GO:0002931
GO:0005080
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005776
GO:0005783
GO:0005829
GO:0005929
GO:0006351
GO:0006355
GO:0006366
GO:0006511
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0007005
GO:0007032
GO:0008104
GO:0008270
GO:0010508
GO:0010821
GO:0012501
GO:0016192
GO:0016197
GO:0016234
GO:0016235
GO:0016236
GO:0016605
GO:0019899
GO:0019901
GO:0023052
GO:0030017
GO:0030154
GO:0030163
GO:0030674
GO:0030971
GO:0031397
GO:0031410
GO:0031625
GO:0034144
GO:0035255
GO:0035556
GO:0035591
GO:0035973
GO:0036211
GO:0038023
GO:0042169
GO:0042802
GO:0043065
GO:0043122
GO:0043130
GO:0043226
GO:0043231
GO:0043232
GO:0044753
GO:0044754
GO:0044877
GO:0045944
GO:0046578
GO:0046872
GO:0060089
GO:0060090
GO:0061635
GO:0070062
GO:0070342
GO:0070530
GO:0071211
GO:0072659
GO:0097009
GO:0097225
GO:0097413
GO:0098542
GO:0098780
GO:0140036
GO:0140311
GO:0140313
GO:0140693
GO:0140694
GO:1900273
GO:1903078
GO:1905719
HMNXSV003033729
Hs.279891.1.A1_3p_at
ILMN_1662618
PH_hs_0010763
U46751_at
g4505570_3p_s_at
Participates
as an input of
TRIM21 ubiquitinates SQSTM1 (Homo sapiens)
SQSTM1 oligomerizes (Homo sapiens)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Homo sapiens)
p62 is recruited and forms a complex with TRAF6 (Homo sapiens)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)
p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)
as an output of
NFE2L2-dependent SQSTM1 gene expression (Homo sapiens)
as a component of
SQSTM1 oligomer [cytosol] (Homo sapiens)
MAP3K3:SQSTM1 [cytosol] (Homo sapiens)
Ubiquitinated NRIF:Sequestosome [cytosol] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
K7 ub-SQSTM1 [cytosol]
p-S349 SQSTM1 [cytosol]
ub K420 p-S349 SQSTM1 [cytosol]
SQSTM1 [nucleoplasm]
Inferred To
SQSTM1 [cytosol]
(Bos taurus)
SQSTM1 [cytosol]
(Canis familiaris)
SQSTM1 [cytosol]
(Dictyostelium discoideum)
SQSTM1 [cytosol]
(Drosophila melanogaster)
SQSTM1 [cytosol]
(Gallus gallus)
SQSTM1 [cytosol]
(Mus musculus)
SQSTM1 [cytosol]
(Rattus norvegicus)
SQSTM1 [cytosol]
(Sus scrofa)
gldi-4 [cytosol]
(Caenorhabditis elegans)
sqstm1 [cytosol]
(Danio rerio)
sqstm1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003891.1
,
NP_001135771.1
,
NP_001135770.1
,
XP_016865499.1
Guide to Pharmacology - Targets
3213
OpenTargets
ENSG00000161011
HPA
ENSG00000161011-SQSTM1
GeneCards
Q13501
Ensembl
ENSP00000495843
,
ENST00000360718
,
ENST00000640444
,
ENSP00000353944
,
ENSG00000161011
,
ENST00000389805
,
ENSP00000374455
,
ENSP00000491834
,
ENSG00000284099
,
ENST00000643389
PRO
Q13501
Pharos - Targets
Q13501
Orphanet
20429
PDB
5YP7
,
2JY8
,
5YPB
,
5YPG
,
6TGY
,
5YPC
,
5YPH
,
5YP8
,
6KHZ
,
6MJ7
,
2JY7
,
7R1O
,
5YPE
,
6JM4
,
4UF8
,
5YPF
,
5YPA
,
4MJS
,
4UF9
,
2K0B
,
6TH3
,
2KNV
,
1Q02
Interactors (59)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.978
31
UniProt:P60520 GABARAPL2
3
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [cytosol]
(R-HSA-5671758)
0.97
25
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.967
21
UniProt:Q9H0R8 GABARAPL1
3
GABARAPL1 [autophagosome membrane]
(R-HSA-5683637)
GABARAPL1(1-117) [cytosol]
(R-HSA-5682659)
GABARAPL1 [cytosol]
(R-HSA-5671757)
0.953
18
UniProt:Q9H492 MAP1LC3A
3
MAP1LC3A [autophagosome membrane]
(R-HSA-5683640)
MAP1LC3A(1-121) [cytosol]
(R-HSA-5682681)
MAP1LC3A [cytosol]
(R-HSA-5205676)
0.951
16
UniProt:O95166 GABARAP
3
GABARAP [autophagosome membrane]
(R-HSA-5683634)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [cytosol]
(R-HSA-975521)
0.948
17
UniProt:Q9BXW4 MAP1LC3C
3
MAP1LC3C [autophagosome membrane]
(R-HSA-5683638)
MAP1LC3C(1-147) [cytosol]
(R-HSA-5682653)
MAP1LC3C [cytosol]
(R-HSA-5679223)
0.901
8
UniProt:P41743 PRKCI
3
PRKCI [nucleoplasm]
(R-HSA-9021345)
PRKCI [cytosol]
(R-HSA-58206)
PRKCI [plasma membrane]
(R-HSA-420005)
0.894
11
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.888
10
IntAct:EBI-4399559 UBIQ
0.829
6
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.806
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.801
8
UniProt:Q14596 NBR1
2
NBR1 [peroxisomal membrane]
(R-HSA-9665177)
NBR1 [cytosol]
(R-HSA-9665180)
0.775
7
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.771
11
UniProt:P58004 SESN2
1
SESN2 [cytosol]
(R-HSA-5629143)
0.728
9
UniProt:Q05513 PRKCZ
5
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
PRKCZ [cytosol]
(R-HSA-58218)
PRKCZ [cell junction]
(R-HSA-2134483)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
0.725
6
UniProt:Q8IZQ1 WDFY3
0.709
7
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.688
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.67
18
UniProt:Q15038 DAZP2
0.666
4
UniProt:P54253 ATX1
0.666
4
UniProt:P07437 TUBB
3
TUBB [cytosol]
(R-HSA-9020816)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [extracellular region]
(R-HSA-380317)
0.666
4
UniProt:Q13163 MAP2K5
1
MAP2K5 [cytosol]
(R-HSA-198722)
0.666
5
UniProt:Q9BPW8 NIPS1
0.65
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.635
3
UniProt:P11473 VDR
2
polySUMO2-VDR [nucleoplasm]
(R-HSA-4546376)
VDR [nucleoplasm]
(R-HSA-375512)
0.591
4
UniProt:Q6IRU7
1
Cep78 [cytosol]
(R-MMU-380304)
0.564
2
UniProt:Q96CV9 OPTN
6
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
0.558
7
UniProt:Q9UGJ0 PRKAG2
2
PRKAG2 [nucleoplasm]
(R-HSA-164130)
PRKAG2 [cytosol]
(R-HSA-200419)
0.556
3
UniProt:O14682 ENC1
0.556
7
UniProt:O14576-2 O145762
0.556
3
UniProt:Q9UBQ0-2 VPS29
0.556
3
UniProt:P34972 CNR2
1
CNR2 [plasma membrane]
(R-HSA-419372)
0.556
5
UniProt:P19544-6 WT1
0.556
3
UniProt:P12709
4
GPI [secretory granule lumen]
(R-SCE-6801495)
GPI [extracellular region]
(R-SCE-6806478)
GPI [ficolin-1-rich granule lumen]
(R-SCE-6801506)
GPI [cytosol]
(R-SCE-70468)
0.556
3
UniProt:A8K2U6 A8K2U6
0.556
3
IntAct:EBI-25830852 RZPDO839G03145
0.556
3
UniProt:P17028 ZNF24
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:P0DMV8 HSPA1A
4
HSPA1A [nucleoplasm]
(R-HSA-6792605)
HSPA1A [extracellular region]
(R-HSA-6805872)
HSPA1A [ficolin-1-rich granule lumen]
(R-HSA-6801496)
HSPA1A [cytosol]
(R-HSA-6792602)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
6
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:Q2V2M9 FHOD3
0.543
6
UniProt:Q2V2M9-4 FHOD3
0.543
4
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.543
3
UniProt:O95817 BAG3
1
BAG3 [cytosol]
(R-HSA-5255451)
0.537
3
UniProt:P57739 CLDN2
2
CLDN2 [plasma membrane]
(R-HSA-419994)
CLDN2 [cell junction]
(R-HSA-421235)
0.537
4
UniProt:Q15334 L2GL1
0.527
2
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
3
UniProt:P16070 CD44
2
CD44 [secretory granule membrane]
(R-HSA-6804776)
CD44 [plasma membrane]
(R-HSA-1031688)
0.527
2
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.524
2
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.524
4
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.524
2
UniProt:P38182
12
ATG8 [cytosol]
(R-SCE-5205651)
ATG8 [cytosol]
(R-SCE-5205676)
ATG8 [cytosol]
(R-SCE-975521)
ATG8 [cytosol]
(R-SCE-5679223)
ATG8 [cytosol]
(R-SCE-5682696)
ATG8 [cytosol]
(R-SCE-5682674)
ATG8 [cytosol]
(R-SCE-5682653)
ATG8 [cytosol]
(R-SCE-5682681)
ATG8 [autophagosome membrane]
(R-SCE-5683634)
ATG8 [autophagosome membrane]
(R-SCE-5683638)
ATG8 [autophagosome membrane]
(R-SCE-5683640)
ATG8 [autophagosome membrane]
(R-SCE-5683641)
0.508
3
UniProt:P12504 VIF
0.499
2
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.499
2
UniProt:O70405
7
ULK1 [recycling endosome]
(R-MMU-8854761)
phospho-p-S758-ULK1 [cytosol]
(R-MMU-5672131)
phospho-p-S317,467,556,638,T575-ULK1 [cytosol]
(R-MMU-5673747)
phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-MMU-5675858)
phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-MMU-8948047)
ULK1 [mitochondrial outer membrane]
(R-MMU-8948145)
ULK1 [cytosol]
(R-MMU-1632847)
0.499
2
UniProt:Q9NX00 TM160
0.483
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
14
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