Reactome | CYP21A2 21-hydroxylates PROG

CYP21A2 21-hydroxylates PROG

Stable Identifier

R-HSA-193964

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

O2 + progesterone + reduced (NADPH--hemoprotein reductase) => 21-hydroxyprogesterone + H(+) + H2O + oxidized (NADPH--hemoprotein reductase), 21-hydroxylation of progesterone to form 11-deoxycorticosterone, progesterone + NAPDH + H+ + O2 => 11-deoxycorticosterone + NADP+ + H2O

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Endogenous sterols (Homo sapiens)
        
        CYP21A2 21-hydroxylates PROG (Homo sapiens)
- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Metabolism of steroid hormones (Homo sapiens)
      - Mineralocorticoid biosynthesis (Homo sapiens)
        
        CYP21A2 21-hydroxylates PROG (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Progesterone, NAPDH + H+, and O2 react to form 11-deoxycorticosterone, NADP+ and H2O. This reaction is catalyzed by CYP21A2 associated with the endoplasmic reticulum membrane.

Literature References

PubMed ID	Title	Journal	Year
3487786	Structure of human steroid 21-hydroxylase genes Dupont, B, New, MI, White, PC	Proc Natl Acad Sci U S A	1986
3038528	Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia Campbell, RD, Porter, RR, Yu, CY, Rodrigues, NR, Carroll, MC, Dunham, I	EMBO J	1987