CYP21A2 21-hydroxylates PROG

Stable Identifier
R-HSA-193964
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
21-hydroxylation of progesterone to form 11-deoxycorticosterone, progesterone + NAPDH + H+ + O2 => 11-deoxycorticosterone + NADP+ + H2O
ReviewStatus
5/5
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Progesterone, NAPDH + H+, and O2 react to form 11-deoxycorticosterone, NADP+ and H2O. This reaction is catalyzed by CYP21A2 associated with the endoplasmic reticulum membrane.
Literature References
PubMed ID Title Journal Year
3487786 Structure of human steroid 21-hydroxylase genes

Dupont, B, New, MI, White, PC

Proc Natl Acad Sci U S A 1986
3038528 Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia

Campbell, RD, Porter, RR, Yu, CY, Rodrigues, NR, Carroll, MC, Dunham, I

EMBO J 1987
Participants
Participates
Catalyst Activity

steroid 21-monooxygenase activity of CYP21A2 [endoplasmic reticulum membrane]

Orthologous Events
Authored
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