CYP11B2 18-hydroxylates CORST to 18HCORST

Stable Identifier
R-HSA-193995
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix, mitochondrial inner membrane
Synonyms
corticosterone + 2 H(+) + O2 + 2 reduced (adrenodoxin) => 18-hydroxycorticosterone + H2O + 2 oxidized (adrenodoxin), corticosterone + NADPH + H+ + O2 => 18-hydroxycorticosterone + NADP+ + H2O
ReviewStatus
4/5
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CYP11B2 18-hydroxylates CORST to 18HCORST
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Corticosterone, NADPH + H+, and O2 react to form 18-hydroxycorticosterone, NADP+, and H2O. This reaction is catalyzed by CYP11B2 associated with the inner mitochondrial membrane.
Literature References
PubMed ID Title Journal Year
2256920 Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism

Nakao, K, Ohnishi, T, Mitsuuchi, Y, Yamamoto, Y, Toda, K, Kuribayashi, I, Sumimoto, H, Ichikawa, Y, Kawainoto, T, Shizuta, Y, Miyahara, K, Yokoyama, Y, Imura, H, Hosoda, K

Biochem Biophys Res Commun 1990
2592361 Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)

Mornet, E, White, PC, Vitek, A, Dupont, J

J Biol Chem 1989
Participants
Input
Output
Participates
as an event of
Catalyst Activity

steroid hydroxylase activity of CYP11B2 [mitochondrial inner membrane]

Physical Entity
CYP11B2 [mitochondrial inner membrane] (Homo sapiens)
Activity
steroid hydroxylase activity (GO:0008395)
Orthologous Events
CYP11B2 18-hydroxylates CORST to 18HCORST (Bos taurus)
CYP11B2 18-hydroxylates CORST to 18HCORST (Canis familiaris)
CYP11B2 18-hydroxylates CORST to 18HCORST (Mus musculus)
CYP11B2 18-hydroxylates CORST to 18HCORST (Rattus norvegicus)
CYP11B2 18-hydroxylates CORST to 18HCORST (Sus scrofa)
CYP11B2 18-hydroxylates CORST to 18HCORST (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2008-10-01)
Reviewed
Hill, DP  (2024-04-04)
D'Eustachio, P  (2007-04-21)
Created
Jassal, B  (2007-03-06)
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