Glucocorticoid biosynthesis

Stable Identifier
R-HSA-194002
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Glucocorticoid biosynthesis
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Cortisol, the major human glucocorticoid, is synthesized in the zona fasciculata of the adrenal cortex from pregnenolone. Pregnenolone is converted to 17alpha-hydoxyprogesterone in two reactions, both catalyzed by 3-beta-hydroxysteroid dehydrogenase/isomerase. 17Alpha-hydroxyprogesterone is hydroxylated by CYP21A2 to form 11-deoxycortisol, which in turn is converted to cortisol by CYP11B1. The conversion of the active steroid hormone, cortisol, to inactive cortisone occurs in many tissues, notably the liver (Payne and Hales 2004).
Literature References
PubMed ID Title Journal Year
15583024 Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones

Payne, AH, Hales, DB

Endocr Rev 2004
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Events
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Event Information
Go Biological Process
glucocorticoid biosynthetic process (0006704)
Orthologous Events
Glucocorticoid biosynthesis (Bos taurus)
Glucocorticoid biosynthesis (Caenorhabditis elegans)
Glucocorticoid biosynthesis (Canis familiaris)
Glucocorticoid biosynthesis (Danio rerio)
Glucocorticoid biosynthesis (Dictyostelium discoideum)
Glucocorticoid biosynthesis (Drosophila melanogaster)
Glucocorticoid biosynthesis (Gallus gallus)
Glucocorticoid biosynthesis (Mus musculus)
Glucocorticoid biosynthesis (Rattus norvegicus)
Glucocorticoid biosynthesis (Schizosaccharomyces pombe)
Glucocorticoid biosynthesis (Sus scrofa)
Glucocorticoid biosynthesis (Xenopus tropicalis)
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2007-04-21)
Created
Jassal, B  (2007-03-06)
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