CYP11B2 oxidises 11DCORST to CORST

Stable Identifier
R-HSA-194017
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix, mitochondrial inner membrane
Synonyms
21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced (adrenodoxin) => corticosterone + H2O + 2 oxidized (adrenodoxin), 11-deoxycorticosterone + NADPH + H+ + O2 => corticosterone + H2O + NADP+
ReviewStatus
4/5
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CYP11B2 oxidises 11DCORST to CORST
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Cytochrome P450 11B2, mitochondrial (CYP11B2 aka aldosterone hydroxylase) is an enzyme necessary for aldosterone biosynthesis via corticosterone (CORST) and 18-hydroxycorticosterone (18HCORST). The 11-beta oxidation of 11-deoxycorticosterone (11DCORST) leads to corticosterone (CORST) and 18-hydroxylation of this leads to 18-hydroxycorticosterone (18HCORST). 18-oxidation of 18HCORST yields aldosterone.
Literature References
PubMed ID Title Journal Year
1741400 Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans

Toda, K, Nakao, K, Ichikawa, Y, Ohnishi, T, Ulick, S, Kawamoto, T, Shizuta, Y, Miura, S, Miyahara, K, Yokoyama, Y, Imura, H, Mitsuuchi, Y

Proc Natl Acad Sci U S A 1992
2592361 Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)

Mornet, E, White, PC, Vitek, A, Dupont, J

J Biol Chem 1989
Participants
Input
Output
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as an event of
Catalyst Activity

steroid 11-beta-monooxygenase activity of CYP11B2 [mitochondrial inner membrane]

Physical Entity
CYP11B2 [mitochondrial inner membrane] (Homo sapiens)
Activity
steroid 11-beta-monooxygenase activity (GO:0004507)
Orthologous Events
CYP11B2 oxidises 11DCORST to CORST (Bos taurus)
CYP11B2 oxidises 11DCORST to CORST (Canis familiaris)
CYP11B2 oxidises 11DCORST to CORST (Mus musculus)
CYP11B2 oxidises 11DCORST to CORST (Rattus norvegicus)
CYP11B2 oxidises 11DCORST to CORST (Sus scrofa)
CYP11B2 oxidises 11DCORST to CORST (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2008-10-01)
Reviewed
Hill, DP  (2024-04-04)
D'Eustachio, P  (2007-04-21)
Created
Jassal, B  (2007-03-06)
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