Transport (influx) of bile salts and acids by OATP-A

Stable Identifier
R-HSA-194130
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
SLCO1A2 transports
ReviewStatus
5/5
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A molecule of extracellular bile salt (glyco- or taurocholate or taurochenodeoxycholate) or bile acid (cholate or chenodeoxycholate) is transported into the cytosol, mediated by OATP-A (SLCO1A2) in the plasma membrane. Bile salts and acids exist in the blood as complexes with serum albumin, and their uptake by OATP-A must involve disruption of this complex, but the molecular mechanism coupling release of a bile salt or acid from albumin to its uptake by OATP-A is unknown. In the body, OATP-A is expressed only at low levels on the basolateral surfaces of hepatocytes and may play only a minor role in the uptake of bile salts and acids by the liver (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).
Literature References
PubMed ID Title Journal Year
7557095 Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

Meier, PJ, Schteingart, CD, Hagenbuch, B, Wolkoff, AW, Kullak-Ublick, GA, Hofmann, AF, Stieger, B

Gastroenterology 1995
Participants
Participates
Catalyst Activity

bile acid transmembrane transporter activity of SLCO1A2 [plasma membrane]

Orthologous Events
Cross References
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