ABCC3 transports bile salts from cytosol to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
Efflux of bile salts from enterocytes to portal system by MRP3
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A molecule of glycocholate, taurocholate, or taurochenodeoxycholate is transported from the cytosol to the extracellular space, coupled to the hydrolysis of a molecule of cytosolic ATP to ADP and orthophosphate. This reaction is mediated by ABCC3 (MRP3). In the body, this reaction mediates the release of bile salts from enterocytes into the blood (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). In the cytosol, bile salts and acids are bound to a carrier protein, FABP6 (I-BABP) (Fujita et al. 1995), and in the blood these molecules are complexed with albumin. The mechanisms by which transport across the plasma membrane is coupled to release from FABP6 and binding to albumin are unknown, so the entire process is annotated as a single concerted event.
Literature References
PubMed ID Title Journal Year
10987286 Transport of amphipathic anions by human multidrug resistance protein 3

Rea, PA, Zeng, H, Kruh, GD, Liu, G

Cancer Res 2000
12220224 Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter

Borst, P, Kuil, A, Zelcer, N, Bot, I, Saeki, T

Biochem J 2003
12704183 Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions

Sarkadi, B, Varadi, A, Szeri, F, Bodo, A, Bakos, E

J Biol Chem 2003
Catalyst Activity

ABC-type bile acid transporter activity of ABCC3 [plasma membrane]

Orthologous Events
Cross References
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