SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-194187
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Co-transport (influx) of bile salts and acids and sodium ions by ASBT
ReviewStatus
5/5
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SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol
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A molecule of extracellular bile salt or bile acid (cholate, chenodeoxycholate, or their glycine or taurine conjugates) and a sodium ion are transported into the cytosol, mediated by ASBT (apical sodium-dependent bile acid transporter; SLC10A2) in the plasma membrane. In the body, ASBT is expressed on the apical surfaces of enterocytes, and this reaction is the first step in the process by which bile salts and acids are reaborbed from the intestinal lumen and returned to the liver (Kullak-Ublick et al. 2004, Trauner & Boyer 2002). Cytosolic ileal bile acid binding protein (IBABP, FABP6) mediates the transcellular movement of bile acids to the basolateral membrane across which they exit the cells via organic solute transporters (OST) (Kurz et al. 2003). Between the two transport systems (ASBT and OST), ~95% of bile acids and salts are absorbed in the terminal ileum and returned back to the liver via the portal system to be uptaken and resecreted in bile.
Literature References
PubMed ID Title Journal Year
12486725 Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures

Kurz, M, Brachvogel, V, Matter, H, Stengelin, S, Thüring, H, Kramer, W

Proteins 2003
12663868 Bile salt transporters: molecular characterization, function, and regulation

Boyer, JL, Trauner, M

Physiol Rev 2003
14699511 Enterohepatic bile salt transporters in normal physiology and liver disease

Kullak-Ublick, GA, Stieger, B, Meier, PJ

Gastroenterology 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

bile acid:sodium symporter activity of SLC10A2 [plasma membrane]

Physical Entity
SLC10A2 [plasma membrane] (Homo sapiens)
Activity
bile acid:sodium symporter activity (GO:0008508)
This event is regulated
Positively by
Regulator
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
Orthologous Events
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Bos taurus)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Canis familiaris)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Danio rerio)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Gallus gallus)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Mus musculus)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Sus scrofa)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Xenopus tropicalis)
Authored
D'Eustachio, P  (2007-03-10)
Reviewed
D'Eustachio, P  (2007-04-30)
Created
D'Eustachio, P  (2007-03-10)
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