YWHAE [cytosol]

Stable Identifier
R-HSA-194368
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
14-3-3 protein epsilon, 143E_HUMAN, 14-3-3 epsilon
Locations in the PathwayBrowser for interactor UniProt:P30304 CDC25A
Expand all
External Reference Information
External Reference
UniProt:P62258 YWHAE
Gene Names
YWHAE
Chain
chain:1-255
Reference Genes
BioGPS Gene:7531 YWHAE
COSMIC (genes):YWHAE YWHAE
CTD Gene:7531 YWHAE
dbSNP Gene:7531 YWHAE
ENSEMBL:ENSG00000108953 YWHAE
ENSEMBL:ENSG00000274474 YWHAE
HGNC:12851 YWHAE
KEGG:hsa:7531 YWHAE
Monarch:7531 YWHAE
NCBI Gene:7531 YWHAE
OMIM:605066 YWHAE
UCSC:P62258 YWHAE
Reference Transcript
Other Identifiers
1011_s_at
11739011_s_at
11753092_s_at
11753517_s_at
11753518_x_at
11758309_s_at
11762793_at
210317_PM_s_at
210317_s_at
210996_PM_s_at
210996_s_at
2578538
3052111
3052117
3740125
3740127
3740128
3740129
3740130
3740131
3740132
3740133
3740134
3740135
3740139
3740141
3740142
3740143
3740144
3740146
3740147
3740148
3740149
3740155
3740156
3740157
3740158
3740160
3740161
3752151
7531
8011011
8055476
A_23_P72285
A_24_P123011
A_24_P123012
A_33_P3407636
GE59242
GO:0000165
GO:0001764
GO:0002376
GO:0002753
GO:0003064
GO:0003723
GO:0005246
GO:0005515
GO:0005634
GO:0005737
GO:0005783
GO:0005829
GO:0005886
GO:0005925
GO:0006605
GO:0007165
GO:0007346
GO:0008104
GO:0015459
GO:0016020
GO:0019855
GO:0019899
GO:0019903
GO:0019904
GO:0021762
GO:0021766
GO:0021987
GO:0023026
GO:0031410
GO:0031625
GO:0031966
GO:0034122
GO:0034504
GO:0034605
GO:0035308
GO:0035332
GO:0035556
GO:0035591
GO:0042470
GO:0042802
GO:0042826
GO:0043226
GO:0044325
GO:0045296
GO:0046827
GO:0046982
GO:0048856
GO:0048870
GO:0050815
GO:0051219
GO:0051220
GO:0051480
GO:0060090
GO:0060306
GO:0070062
GO:0070972
GO:0086013
GO:0086091
GO:0097110
GO:0098772
GO:0140311
GO:0140313
GO:1901016
GO:1902309
GO:1905913
HMNXSV003007677
HMNXSV003028626
HMNXSV003029125
ILMN_1807535
ILMN_2252136
PH_hs_0029000
PH_hs_0031355
TC17000972.hg
TC17002434.hg
U54778_at
g4096984_3p_a_at
g984318_3p_a_at
Participates
as a component of
as an input of
Inferred To
rad24 [cytosol] (Schizosaccharomyces pombe)
ywhae1 [cytosol] (Danio rerio)
14-3-3 epsilon [cytosol] (Mus musculus)
rad25 [cytosol] (Schizosaccharomyces pombe)
Ywhae [cytosol] (Rattus norvegicus)
ywhae [cytosol] (Xenopus tropicalis)
BMH2 [cytosol] (Saccharomyces cerevisiae)
YWHAE [cytosol] (Bos taurus)
YWHAE [cytosol] (Canis familiaris)
YWHAE [cytosol] (Gallus gallus)
YWHAE [cytosol] (Sus scrofa)
fttB [cytosol] (Dictyostelium discoideum)
14-3-3epsilon [cytosol] (Drosophila melanogaster)
Homologues of YWHAE [cytosol] (Schizosaccharomyces pombe)
Cross References
RefSeq
OpenTargets
ENSEMBL
HPA
PRO
Pharos - Targets
GlyGen
Orphanet
PDB
Interactors (291)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P61981 YWHAG  1 0.94 17
 UniProt:P63104 YWHAZ  2 0.924 17
 UniProt:P54253 ATX1      0.919 15
 UniProt:P31946 YWHAB  1 0.919 15
 UniProt:P27348 YWHAQ  1 0.916 14
 UniProt:P04049 RAF1  20 0.913 24
 UniProt:Q04917 YWHAH  1 0.91 13
 UniProt:P56524 HDAC4  3 0.865 9
 UniProt:P15056 BRAF  20 0.859 10
 UniProt:P46937 YAP1  8 0.842 9
 UniProt:Q92934 BAD  4 0.833 8
 UniProt:Q9Y2U5 M3K2      0.825 7
 UniProt:Q5S007 LRRK2  1 0.823 8
 UniProt:P10398 ARAF  4 0.809 8
 UniProt:Q99759 MAP3K3  1 0.802 6
 UniProt:P27448 MARK3  1 0.786 9
 UniProt:P22681 CBL  20 0.773 6
 UniProt:P30307 CDC25C  8 0.773 6
 UniProt:O96013 PAK4  1 0.763 10
 UniProt:P00519 ABL1  6 0.763 6
 UniProt:P30305 CDC25B  3 0.763 6
 UniProt:P30304 CDC25A  6 0.76 6
 UniProt:P35568 IRS1  5 0.76 8
 UniProt:O15151 MDM4  5 0.758 5
 UniProt:Q9NQU5 PAK6  1 0.744 5
 UniProt:Q5PRF9 SMAG2      0.744 6
 UniProt:P19484 TFEB  1 0.744 5
 UniProt:Q00536 CDK16      0.744 5
 UniProt:Q13671 RIN1  1 0.738 4
 UniProt:Q9GZV5 WWTR1  3 0.738 4
 UniProt:Q7L804 RAB11FIP2  1 0.737 6
 UniProt:O43896 KIF1C  1 0.734 6
 UniProt:Q99469 STAC      0.734 4
 UniProt:Q13627 DYRK1A  1 0.734 5
 UniProt:Q6IQ23 PKHA7      0.727 7
 UniProt:Q96PU5 NEDD4L  2 0.727 6
 UniProt:Q7KZI7 MARK2      0.725 5
 UniProt:Q9UJM3 ERRFI      0.725 4
 UniProt:Q9NRR6 INPP5E  2 0.725 5
 UniProt:Q9Y3M2 CBY1  3 0.725 5
 UniProt:Q13233 MAP3K1  2 0.71 4
 UniProt:Q6ICG6 K0930      0.708 5
 UniProt:Q9H4A3 WNK1  1 0.707 7
 UniProt:Q6R327 RICTOR  1 0.706 5
 UniProt:Q7Z309 PBIR2      0.706 4
 UniProt:Q9P2M7 CGN  1 0.706 5
 UniProt:Q9UQC2 GAB2  5 0.706 5
 UniProt:O60343 TBC1D4  2 0.695 6
 UniProt:Q96S53 TESK2      0.695 5
 UniProt:O43524 FOXO3  11 0.695 5
 UniProt:Q5SW79 CE170      0.676 5
 UniProt:P49815 TSC2  4 0.675 3
 UniProt:Q5TCX8 M3K21      0.671 5
 UniProt:Q9Y2K2 SIK3      0.671 5
 UniProt:Q5VZ89 DENND4C  1 0.671 5
 UniProt:P26045 PTPN3  3 0.671 4
 UniProt:P08069 IGF1R  3 0.669 6
 UniProt:Q13470 TNK1      0.669 4
 UniProt:Q96N96 SPATA13  1 0.669 4
 UniProt:Q6P597 KLC3  1 0.669 4
 UniProt:P57059 SIK1  1 0.669 4
 UniProt:P62258 YWHAE  1 0.667 3
 UniProt:Q13111 CAF1A      0.659 3
 UniProt:Q99683 MAP3K5  1 0.659 3
 UniProt:Q9NSK0 KLC4  1 0.649 6
 UniProt:Q7Z460 CLASP1  1 0.649 7
 UniProt:O60333 KIF1B  1 0.649 6
 UniProt:O75122 CLASP2  1 0.649 8
 UniProt:Q86W92 PPFIBP1  5 0.649 5
 UniProt:Q6UUV9 CRTC1  1 0.649 5
 UniProt:O14654 IRS4  2 0.649 6
 UniProt:Q92974 ARHGEF2  1 0.649 6
 UniProt:O14639 ABLIM1  1 0.649 7
 UniProt:Q9H0B6 KLC2  1 0.649 6
 UniProt:Q6PKG0 LARP1  1 0.649 6
 UniProt:Q9UQB8 BAIAP2  1 0.649 7
 UniProt:Q6VAB6 KSR2  1 0.643 7
 UniProt:Q9Y2J2 EPB41L3  1 0.643 3
 UniProt:O43900 PRIC3      0.643 5
 UniProt:Q53ET0 CRTC2  1 0.643 4
 UniProt:Q9UQL6 HDAC5  1 0.643 4
 UniProt:Q02750 MAP2K1  20 0.643 5
 UniProt:Q9BZ23 PANK2  1 0.643 3
 UniProt:P28290 ITPI2      0.64 4
 UniProt:Q96GE4 CEP95      0.64 3
 UniProt:Q9P0V3 SH3BP4  1 0.64 4
 UniProt:O94921 CDK14      0.632 4
 UniProt:O92972-PRO_0000278742      0.625 5
 UniProt:Q07002 CDK18      0.623 4
 UniProt:Q12778 FOXO1  5 0.623 5
 UniProt:Q00537 CDK17      0.623 4
 UniProt:Q3V6T2 CCDC88A  1 0.615 4
 UniProt:Q5JXC2 MIIP      0.615 3
 UniProt:O14924 RGS12  1 0.615 4
 UniProt:Q9P1Y5 CAMP3      0.615 3
 UniProt:Q969F2 NKD2      0.615 3
 UniProt:Q96NE9 FRMD6      0.615 3
 UniProt:O60292 SI1L3      0.615 5
 UniProt:P13569 CFTR  17 0.615 18
 UniProt:Q08495 DMTN  1 0.615 3
 UniProt:Q9UKT5 FBXO4  1 0.612 5
 UniProt:Q99959 PKP2  2 0.604 5
 UniProt:Q9UPU9 SMAG1      0.604 5
 UniProt:P40818 USP8  2 0.604 5
 UniProt:Q8IVT5 KSR1  5 0.604 4
 UniProt:Q9Y3R0 GRIP1  2 0.604 4
 UniProt:O43379 WDR62      0.604 5
 UniProt:Q6P0Q8 MAST2      0.604 4
 UniProt:P31947 SFN  1 0.604 5
 UniProt:P47974 ZFP36L2  1 0.604 5
 UniProt:Q14678-2 KANK1      0.602 3
 UniProt:O94875 SRBS2      0.594 4
 UniProt:P21580 TNFAIP3  1 0.573 3
 UniProt:Q8NHQ8 RASF8      0.569 4
 UniProt:Q9Y6R0 NUMBL      0.569 3
 UniProt:Q92625 ANS1A      0.569 3
 UniProt:Q7Z401 DENND4A  1 0.569 5
 UniProt:Q96N67 DOCK7  1 0.569 4
 UniProt:Q5TCZ1 SH3PXD2A  1 0.569 4
 UniProt:Q12923 PTPN13  2 0.569 4
 UniProt:P78524 ST5  1 0.569 3
 UniProt:Q86SQ0 PHLB2      0.569 4
 UniProt:Q9NYL2 M3K20      0.569 3
 UniProt:Q9P2F8 SI1L2      0.569 4
 UniProt:Q6WKZ4 RFIP1      0.569 4
 UniProt:P49757 NUMB  1 0.569 4
 UniProt:Q6ZV73 FGD6      0.569 3
 UniProt:Q86TI0 TBC1D1  2 0.569 4
 UniProt:Q13625 TP53BP2  1 0.569 4
 UniProt:Q8TEW0 PARD3  3 0.569 5
 UniProt:O15049 N4BP3      0.569 4
 UniProt:Q9HAU0 PLEKHA5  1 0.569 4
 UniProt:Q3KQU3 MA7D1      0.569 3
 UniProt:Q9Y4H2 IRS2  4 0.569 4
 UniProt:P10636-8 MAPT  3 0.569 11
 UniProt:O00443 PIK3C2A  3 0.569 4
 UniProt:Q02241 KIF23  3 0.569 4
 UniProt:P26196 DDX6  1 0.564 3
 UniProt:O75494 SRSF10  1 0.564 3
 UniProt:Q9P286 PAK5  2 0.564 3
 UniProt:Q8TC76 F110B      0.564 3
 UniProt:O00444 PLK4  1 0.564 3
 UniProt:Q5U5Q3 MEX3C  1 0.564 3
 UniProt:Q86UK7 ZN598      0.564 3
 UniProt:Q8N5S9 CAMKK1  4 0.564 3
 UniProt:Q86X27 RGPS2      0.564 3
 UniProt:Q9NXR1 NDE1  1 0.564 3
 UniProt:Q02156 PRKCE  2 0.564 4
 UniProt:Q8N568 DCLK2      0.564 3
 UniProt:P46934 NEDD4  1 0.564 3
 UniProt:Q9H1K1 ISCU  1 0.564 3
 UniProt:Q13322 GRB10  2 0.564 3
 UniProt:P58340 MLF1      0.558 3
 UniProt:P56524-2 HDAC4      0.556 3
 UniProt:Q06251 YL177      0.556 3
 UniProt:Q86Z20 CC125      0.556 3
 UniProt:Q08981 ACM1      0.556 3
 UniProt:Q9NRI5 DISC1      0.553 3
 UniProt:Q9H0I2 ENKD1      0.547 2
 UniProt:Q15884 EREP1      0.547 2
 UniProt:Q14671 PUM1  1 0.539 5
 UniProt:Q8N8E3 CE112      0.539 4
 UniProt:Q9NYJ8 TAB2  4 0.536 2
 UniProt:Q9NYF3 FA53C      0.527 2
 UniProt:Q9BQK8 LPIN3  3 0.527 2
 UniProt:Q6ZW31 SYDE1  1 0.527 2
 UniProt:Q8ND76 CCNY      0.527 2
 UniProt:Q13112 CAF1B      0.527 3
 UniProt:Q9Y2H9 MAST1      0.527 2
 UniProt:Q8IZ21 PHAR4      0.527 3
 UniProt:P11274 BCR  4 0.527 2
 UniProt:Q14680 MELK      0.527 2
 UniProt:Q96GL9 F163A      0.527 2
 UniProt:Q8TC71 MIEAP      0.527 2
 UniProt:P50749 RASF2      0.527 2
 UniProt:Q9Y2L9 LRCH1      0.527 2
 UniProt:Q9H0K1 SIK2      0.527 2
 UniProt:Q9NZQ3 NCKIPSD  1 0.527 2
 UniProt:Q5VWQ8 DAB2IP  1 0.527 2
 UniProt:Q96PV0 SYNGAP1  1 0.527 3
 UniProt:P57078 RIPK4      0.527 2
 UniProt:Q86X02 CDR2L      0.527 4
 UniProt:Q15139 PRKD1  1 0.527 2
 UniProt:P62993 GRB2  1 0.527 3
 UniProt:Q15032 R3HD1      0.527 2
 UniProt:Q96Q42 ALS2  1 0.527 2
 UniProt:Q9H8N7 ZN395      0.527 3
 UniProt:Q6NUK4 REEP3      0.527 2
 UniProt:Q9HB19 PLEKHA2  1 0.527 2
 UniProt:Q14153 FA53B      0.527 2
 UniProt:Q9P0L2 MARK1      0.527 2
 UniProt:O60825 PFKFB2  1 0.527 3
 UniProt:Q07866 KLC1  3 0.527 2
 UniProt:Q9Y4G8 RAPGEF2  1 0.527 2
 UniProt:Q9ULR3 PPM1H      0.527 2
 UniProt:Q8TEU7 RPGF6      0.527 3
 UniProt:Q96GV9 MACIR      0.527 2
 UniProt:Q8IX03 WWC1  1 0.527 2
 UniProt:Q00613 HSF1  11 0.527 2
 UniProt:Q96L34 MARK4  1 0.527 2
 UniProt:P36507 MAP2K2  12 0.527 3
 UniProt:Q8WX92 NELFB  3 0.527 2
 UniProt:A0MZ66 SHTN1  1 0.527 2
 UniProt:P41743 PRKCI  3 0.527 2
 UniProt:Q61337 Bad  6 0.527 2
 UniProt:Q9P2Y5 UVRAG  2 0.527 2
 UniProt:P56945 BCAR1  4 0.527 5
 UniProt:Q9P0N9 TBC1D7  1 0.527 2
 UniProt:Q70EL4 USP43  1 0.527 2
 UniProt:Q9NQC7 CYLD  3 0.527 2
 UniProt:Q0VF96 CGNL1      0.519 3
 UniProt:P61962 DCAF7  2 0.508 3
 UniProt:Q96AP0 ACD  1 0.508 2
 UniProt:Q96QF0 RAB3IP  1 0.508 3
 UniProt:Q7Z6J0 SH3RF1  1 0.499 3
 UniProt:P09622 DLD  8 0.499 5
 UniProt:P21796 VDAC1  7 0.499 5
 UniProt:Q15154 PCM1  1 0.499 3
 UniProt:O00257-3 CBX4      0.499 2
 UniProt:O43491 EPB41L2  1 0.499 3
 UniProt:P80192 M3K9      0.499 3
 UniProt:P49674 CSNK1E  2 0.499 3
 UniProt:P36957 DLST  5 0.499 4
 UniProt:P49840 GSK3A  3 0.499 3
 UniProt:Q96F86 EDC3  1 0.483 4
 UniProt:Q8IVL1 NAV2      0.483 2
 UniProt:Q9NR80 ARHGEF4  1 0.483 2
 UniProt:O95696 BRD1  1 0.483 2
 UniProt:Q5VT25 CDC42BPA  1 0.483 2
 UniProt:Q8N350 CBARP      0.483 2
 UniProt:Q76I76 SSH2      0.483 3
 UniProt:O94915 FRYL      0.483 2
 UniProt:P85299 PRR5  1 0.483 3
 UniProt:Q8TEH3 DENND1A  2 0.483 3
 UniProt:Q4KWH8 PLCH1  1 0.483 3
 UniProt:Q5T0W9 FAM83B  1 0.483 3
 UniProt:Q12802 AKAP13  1 0.483 3
 UniProt:Q86UU1 PHLB1      0.483 3
 UniProt:Q6ZWE6 PKHM3      0.483 3
 UniProt:P42345 MTOR  2 0.483 3
 UniProt:Q9H6H4 REEP4      0.483 3
 UniProt:Q5SZL2 CE85L      0.483 2
 UniProt:A7KAX9 ARHGAP32  1 0.483 3
 UniProt:Q8WWI1 LMO7  3 0.483 2
 UniProt:Q5VT97 SYDE2  1 0.483 2
 UniProt:O75592 MYCB2      0.483 3
 UniProt:O00750 PIK3C2B  1 0.483 3
 UniProt:Q69YN4 VIR      0.483 2
 UniProt:Q9ULJ3 ZBT21      0.483 2
 UniProt:Q9UJF2 RASAL2  1 0.483 3
 UniProt:P33176 KIF5B  3 0.483 2
 UniProt:Q99550 MPP9      0.483 2
 UniProt:Q9Y580 RBM7  1 0.483 2
 UniProt:Q6AWC2 WWC2      0.483 2
 UniProt:Q9Y4F5 C170B      0.483 3
 UniProt:Q6P1L5 F117B      0.483 3
 UniProt:Q9UPV9 TRAK1  3 0.483 2
 UniProt:Q9HCD6 TANC2      0.483 4
 UniProt:Q9HAP2 MLXIP      0.483 3
 UniProt:Q6UUV7 CRTC3  1 0.483 3
 UniProt:Q86X29 LSR  1 0.483 3
 UniProt:Q9Y6M7 SLC4A7  1 0.483 2
 UniProt:Q8TF72 SHRM3      0.483 2
 UniProt:Q53SF7 COBL1      0.483 2
 UniProt:Q96PY6 NEK1  1 0.483 3
 UniProt:O15056 SYNJ2  1 0.483 2
 UniProt:O94964 MTCL2      0.483 3
 UniProt:Q9BZF3 OSBPL6  1 0.483 2
 UniProt:Q96AY4 TTC28      0.483 2
 UniProt:Q6WCQ1 MPRIP  2 0.483 3
 UniProt:Q70EL1 UBP54      0.483 2
 UniProt:Q08AD1 CAMP2      0.483 3
 UniProt:Q9NPI6 DCP1A  1 0.483 2
 UniProt:Q96ST8 CEP89  1 0.483 4
 UniProt:Q13009 TIAM1  2 0.483 2
 UniProt:Q96RT1 ERBIN  1 0.483 3
 UniProt:O00429 DNM1L  2 0.483 4
 UniProt:Q92538 GBF1  2 0.483 3
 UniProt:Q6N021 TET2  1 0.483 2
 UniProt:Q9UQ84 EXO1  1 0.483 2
 UniProt:Q9HC77 CENPJ  2 0.483 2
 UniProt:Q86V48 LUZP1      0.471 3
 UniProt:O35244  3 0.471 2
 UniProt:Q8NEY1 NAV1      0.471 4
 UniProt:Q8N4C8 MINK1  1 0.471 3
 UniProt:Q5VV41 ARHGEF16  1 0.471 4
 UniProt:Q51451 Q51451      0.469 2
 UniProt:P51957-2 NEK4      0.462 2
 UniProt:P51957-1 NEK4      0.462 2
 UniProt:Q76353 Q76353      0.462 2
 UniProt:Q6PJG9 LRFN4  1 0.462 3
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